甘草黄酮B

Licoflavone B

	产品编号	CFN93300
	CAS编号	91433-17-9
	分子式 = 分子量	C₂₅H₂₆O₄ = 390.47
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The roots of Glycyrrhiza inflata
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产品名称	产品编号	CAS编号	包装	QQ客服
甘草黄酮B	CFN93300	91433-17-9	1mg	QQ客服：215959384
甘草黄酮B	CFN93300	91433-17-9	5mg	QQ客服：215959384
甘草黄酮B	CFN93300	91433-17-9	10mg	QQ客服：215959384
甘草黄酮B	CFN93300	91433-17-9	20mg	QQ客服：215959384

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Description:

Licoflavone B has schistosomicidal activity, it showed high S. mansoni ATPase (IC50 of 23.78 uM) and ADPase (IC50 of 31.50 uM) inhibitory activities.

Targets:

Antifection | ATPase | ADPase

In vitro:

J Nat Prod. 2014 Mar 28;77(3):563-70.

Computer-guided approach to access the anti-influenza activity of licorice constituents.[Pubmed: 24313801 ]

Neuraminidase (NA), a key enzyme in viral replication, is the first-line drug target to combat influenza. On the basis of a shape-focused virtual screening, the roots of Glycyrrhiza glabra (licorice) were identified as plant species with an accumulation of constituents that show 3D similarities to known influenza NA inhibitors (NAIs).
METHODS AND RESULTS:
Phytochemical investigation revealed 12 constituents identified as (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2-propen-1-one (1), 3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-ol (2), biochanin B (3), glabrol (4), glabrone (5), hispaglabridin B (6), Licoflavone B (7), licorice glycoside B (8), licorice glycoside E (9), liquiritigenin (10), liquiritin (11), and prunin (12). Eleven of these constituents showed significant influenza virus NA inhibition in a chemiluminescence (CL)-based assay. Additional tests, including (i) a cell-based cytopathic effect inhibition assay (general antiviral activity), (ii) the evaluation of cytotoxicity, (iii) the inhibition of the NA of Clostridium perfringens (CL- and fluorescence (FL)-based assay), and (iv) the determination of self-fluorescence and quenching, provided further perspective on their anti-influenza virus potential, revealing possible assay interference problems and false-positive results.
CONCLUSIONS:
Compounds 1, 3, 5, and 6 showed antiviral activity, most likely caused by the inhibition of NA. Of these, compounds 1, 3, and 6 were highly ranked in shape-focused virtual screening.

In vivo:

Exp Parasitol. 2015 Dec;159:207-14.

Schistosomicidal activity and docking of Schistosoma mansoni ATPDase 1 with licoflavone B isolated from Glycyrrhiza inflata (Fabaceae).[Pubmed: 26454044]

Schistosomiasis is one of the world's major public health problems, and its treatment is widely dependent on praziquantel (PZQ), the only available drug. Schistosoma mansoni ATP diphosphohydrolases are ecto-enzymes localized on the external tegumental surface of S. mansoni and considered an important target for action of new drugs.
METHODS AND RESULTS:
In this work, the in vitro schistosomicidal activity of the crude extract of Glycyrrhiza inflata roots (GI) and its isolated compounds echinatin, licoflavone A and Licoflavone B were evaluated against S. mansoni adult worms. Results showed that GI (200 μg/mL) was active against adult schistosomes, causing 100% mortality after 24 h of incubation. Chromatographic fractionation of GI led to isolation of echinatin, licoflavone A and Licoflavone B. Licoflavone B (25-100 μM) caused 100% mortality, tegumental alterations, and reduction of oviposition and motor activity of all adult worms, without affecting mammalian Vero cells. Confocal laser scanning microscopy showed tegumental morphological alterations and changes on the numbers of tubercles of S. mansoni worms in a dose-dependent manner after incubation with Licoflavone B. Licoflavone B also showed high S. mansoni ATPase (IC50 of 23.78 μM) and ADPase (IC50 of 31.50 μM) inhibitory activities. Docking studies predicted different interactions between Licoflavone B and S. mansoni ATPDase 1, corroborating with the in vitro inhibitory activity.
CONCLUSIONS:
This report demonstrated the first evidence for the schistosomicidal activity of Licoflavone B and suggests that its mechanism of action involve the inhibition of S. mansoni ATP diphosphohydrolases.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.561 mL	12.8051 mL	25.6102 mL	51.2203 mL	64.0254 mL
5 mM	0.5122 mL	2.561 mL	5.122 mL	10.2441 mL	12.8051 mL
10 mM	0.2561 mL	1.2805 mL	2.561 mL	5.122 mL	6.4025 mL
50 mM	0.0512 mL	0.2561 mL	0.5122 mL	1.0244 mL	1.2805 mL
100 mM	0.0256 mL	0.1281 mL	0.2561 mL	0.5122 mL	0.6403 mL

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甘草黄酮B

Licoflavone B

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