Info: Read More
  • 中药标准品生产商,产品定制服务
  • 甘草黄酮B

    Licoflavone B

    甘草黄酮B
    产品编号 CFN93300
    CAS编号 91433-17-9
    分子式 = 分子量 C25H26O4 = 390.47
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Glycyrrhiza inflata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甘草黄酮B CFN93300 91433-17-9 1mg QQ客服:1413575084
    甘草黄酮B CFN93300 91433-17-9 5mg QQ客服:1413575084
    甘草黄酮B CFN93300 91433-17-9 10mg QQ客服:1413575084
    甘草黄酮B CFN93300 91433-17-9 20mg QQ客服:1413575084
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • S.N.D.T. Women's University (India)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • University of Fribourg (Switzerland)
  • Universidad de Antioquia (Colombia)
  • Universidade de Franca (Brazil)
  • Tokyo Woman's Christian University (Japan)
  • The Institute of Cancer Research (United Kingdom)
  • Kamphaengphet Rajabhat University (Thailand)
  • University of Dicle (Turkey)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Universidade Federal de Goias (UFG) (Brazil)
  • University of Perugia (Italy)
  • Agricultural Research Organization (ARO) (Israel)
  • Siksha O Anusandhan University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Hortic Res.2023, 10(9):uhad154.
  • Food Chem.2021, 360:130063.
  • Journal of Mushroom2023, 21(4):215-221.
  • Earth Environ. Sci. 2021, 905:012080.
  • Int J Mol Sci.2018, 19(9):E2601
  • JMicrobiol Biotech Food Sci2021, e4289.
  • Anat Rec (Hoboken).2021, 304(2):323-332.
  • Res Rep Urol.2022, 14:313-326.
  • Molecules.2023, 28(8):3503.
  • Int J Mol Sci.2022, 23(21):12816.
  • J Breast Cancer.2015, 18(2):112-118
  • HortTechnology2016, 26(6):816-819
  • Legume Science2021, 3(4): e101.
  • Journal of functional foods2018, 171-182
  • Planta Med.2019, 85(3):217-224
  • Korean J. Medicinal Crop Sci.2022, 30(2):124-133
  • Chemistry of Natural Compounds2020, 56,423-426
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • J Pharm Biomed Anal.2018, 151:32-41
  • Plants (Basel).2020, 9(11):1422.
  • Separation Science Plus2022, sscp.202200048.
  • Phytochem Anal.2022, doi: 10.1002
  • SRM Institute of Sci&Tech2022, 34(1): 32-37
  • ...
  • 生物活性
    Description: Licoflavone B has schistosomicidal activity, it showed high S. mansoni ATPase (IC50 of 23.78 uM) and ADPase (IC50 of 31.50 uM) inhibitory activities.
    Targets: Antifection | ATPase | ADPase
    In vitro:
    J Nat Prod. 2014 Mar 28;77(3):563-70.
    Computer-guided approach to access the anti-influenza activity of licorice constituents.[Pubmed: 24313801 ]
    Neuraminidase (NA), a key enzyme in viral replication, is the first-line drug target to combat influenza. On the basis of a shape-focused virtual screening, the roots of Glycyrrhiza glabra (licorice) were identified as plant species with an accumulation of constituents that show 3D similarities to known influenza NA inhibitors (NAIs).
    METHODS AND RESULTS:
    Phytochemical investigation revealed 12 constituents identified as (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2-propen-1-one (1), 3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-ol (2), biochanin B (3), glabrol (4), glabrone (5), hispaglabridin B (6), Licoflavone B (7), licorice glycoside B (8), licorice glycoside E (9), liquiritigenin (10), liquiritin (11), and prunin (12). Eleven of these constituents showed significant influenza virus NA inhibition in a chemiluminescence (CL)-based assay. Additional tests, including (i) a cell-based cytopathic effect inhibition assay (general antiviral activity), (ii) the evaluation of cytotoxicity, (iii) the inhibition of the NA of Clostridium perfringens (CL- and fluorescence (FL)-based assay), and (iv) the determination of self-fluorescence and quenching, provided further perspective on their anti-influenza virus potential, revealing possible assay interference problems and false-positive results.
    CONCLUSIONS:
    Compounds 1, 3, 5, and 6 showed antiviral activity, most likely caused by the inhibition of NA. Of these, compounds 1, 3, and 6 were highly ranked in shape-focused virtual screening.
    In vivo:
    Exp Parasitol. 2015 Dec;159:207-14.
    Schistosomicidal activity and docking of Schistosoma mansoni ATPDase 1 with licoflavone B isolated from Glycyrrhiza inflata (Fabaceae).[Pubmed: 26454044]
    Schistosomiasis is one of the world's major public health problems, and its treatment is widely dependent on praziquantel (PZQ), the only available drug. Schistosoma mansoni ATP diphosphohydrolases are ecto-enzymes localized on the external tegumental surface of S. mansoni and considered an important target for action of new drugs.
    METHODS AND RESULTS:
    In this work, the in vitro schistosomicidal activity of the crude extract of Glycyrrhiza inflata roots (GI) and its isolated compounds echinatin, licoflavone A and Licoflavone B were evaluated against S. mansoni adult worms. Results showed that GI (200 μg/mL) was active against adult schistosomes, causing 100% mortality after 24 h of incubation. Chromatographic fractionation of GI led to isolation of echinatin, licoflavone A and Licoflavone B. Licoflavone B (25-100 μM) caused 100% mortality, tegumental alterations, and reduction of oviposition and motor activity of all adult worms, without affecting mammalian Vero cells. Confocal laser scanning microscopy showed tegumental morphological alterations and changes on the numbers of tubercles of S. mansoni worms in a dose-dependent manner after incubation with Licoflavone B. Licoflavone B also showed high S. mansoni ATPase (IC50 of 23.78 μM) and ADPase (IC50 of 31.50 μM) inhibitory activities. Docking studies predicted different interactions between Licoflavone B and S. mansoni ATPDase 1, corroborating with the in vitro inhibitory activity.
    CONCLUSIONS:
    This report demonstrated the first evidence for the schistosomicidal activity of Licoflavone B and suggests that its mechanism of action involve the inhibition of S. mansoni ATP diphosphohydrolases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.561 mL 12.8051 mL 25.6102 mL 51.2203 mL 64.0254 mL
    5 mM 0.5122 mL 2.561 mL 5.122 mL 10.2441 mL 12.8051 mL
    10 mM 0.2561 mL 1.2805 mL 2.561 mL 5.122 mL 6.4025 mL
    50 mM 0.0512 mL 0.2561 mL 0.5122 mL 1.0244 mL 1.2805 mL
    100 mM 0.0256 mL 0.1281 mL 0.2561 mL 0.5122 mL 0.6403 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    汉防己甲素; 粉防己碱; Tetrandrine CFN99166 518-34-3 C38H42N2O6 = 622.76 20mg QQ客服:3257982914
    假石榴碱; 9-Methyl-9-azabicyclo[3.3.1]nonan-3-one CFN70138 552-70-5 C9H15NO = 153.2 20mg QQ客服:1413575084
    1,5-Dihydroxyxanthone; 1,5-Dihydroxyxanthone CFN89131 14686-65-8 C13H8O4 = 228.20 5mg QQ客服:1457312923
    香芹基乙酸; Carvacryl acetate CFN70485 6380-28-5 C12H16O2 = 192.3 5mg QQ客服:3257982914

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产