甘草黄烷酮

Licoflavanone

	产品编号	CFN95213
	CAS编号	119240-82-3
	分子式 = 分子量	C₂₀H₂₀O₅ = 340.4
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The herbs of Erythrina arborescens
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
甘草黄烷酮	CFN95213	119240-82-3	1mg	QQ客服：3257982914
甘草黄烷酮	CFN95213	119240-82-3	5mg	QQ客服：3257982914
甘草黄烷酮	CFN95213	119240-82-3	10mg	QQ客服：3257982914
甘草黄烷酮	CFN95213	119240-82-3	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Sanford Burnham Medical Research Institute (USA)

University of Otago (New Zealand)

Semmelweis Unicersity (Hungary)

University of Madras (India)

University of Padjajaran (Indonesia)

University of Cincinnati (USA)

Korea Food Research Institute(KFRI) (Korea)

Complutense University of Madrid (Spain)

University of Brasilia (Brazil)

Rio de Janeiro State University (Brazil)

University of Malaya (Malaysia)

Korea Institute of Oriental Medicine (Korea)

Instytut Nawozów Sztucznych w Pu?awach (Poland)

John Innes Centre (United Kingdom)

More...

Description:

Licoflavanone exhibits antioxidant and anti-inflammatory activities,it markedly decreases pro-inflammatory cytokines and cyclooxygenase 2/inducible nitric oxide synthase (COX-2/iNOS) expression levels.

Targets:

COX | NOS | NF-kB | MAPK

In vitro:

Antioxidants (Basel). 2019 Jun 20;8(6). pii: E186.

Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathway.[Pubmed: 31226797]

Inflammation represents an adaptive response generated by injuries or harmful stimuli. Natural remedies represent an interesting alternative to traditional therapies, involving several biochemical pathways. Besides, the valorization of agrochemical wastes nowadays seems to be a feasible way to reduce the health spending and improve the accessibility at bioactive natural compounds.
METHODS AND RESULTS:
In this context, the chemical composition of three Glycyrrhiza glabra L. (licorice) leaf extracts, obtained through maceration or ultrasound-assisted method (fresh and dried leaves) was investigated. A guided fractionation obtained three main components: pinocembrin, glabranin and licoflavanone. All the extracts showed similar antioxidant properties, evaluated by 2,2'-diphenyl-1-picrylhydrazyl (DPPH) or 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) Diammonium Salt (ABTS) assay, while, among the isolated compounds, licoflavanone exhibited the best antioxidant activity. The anti-inflammatory activity of the extracts and the purified compounds was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages. Extract C and licoflavanone showed a good anti-inflammatory activity without affecting cell viability, as they decreased nitrite levels even when used at 12.5 μg/mL (p < 0.005) and 50 μM concentration (p < 0.001), respectively.
CONCLUSIONS:
Interestingly, licoflavanone markedly decreased pro-inflammatory cytokines and cyclooxygenase 2/inducible nitric oxide synthase (COX-2/iNOS) expression levels (p < 0.001). A modulation of nuclear factor kappa B/mitogen-activated protein kinases (NF-kB/MAPK) pathway underlay such behavior, highlighting the potential of this natural compound as a new scaffold in anti-inflammatory drug research.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Euchrestaflavanone B; Euchrestaflavanone B	CFN96525	87402-91-3	C₂₅H₂₈O₆ = 424.49	5mg	QQ客服：2159513211
怀槐黄酮; Maackiaflavanone	CFN96521	156162-10-6	C₂₆H₃₀O₆ = 438.51	5mg	QQ客服：1413575084
(2S)-5,7-二羟基-2-[4-羟基-3,5-二(3-甲基丁-2-烯基)苯基]色满-4-酮; Abyssinone V	CFN96511	77263-11-7	C₂₅H₂₈O₅ = 408.49	5mg	QQ客服：215959384
(-)-山豆根素; (-)-Sophoranone	CFN94881	23057-55-8	C₃₀H₃₆O₄ = 460.6	5mg	QQ客服：2056216494
5-羟基广豆根素; 5-Hydroxysophoranone	CFN96529	90686-12-7	C₃₀H₃₆O₅ = 476.61	5mg	QQ客服：215959384
桑根酮醇 P; Sanggenol P	CFN97893	1351931-30-0	C₃₀H₃₆O₆ = 492.6	5mg	QQ客服：1457312923
(+/-)-乙形刺酮素A; (+/-)-Sigmoidin A	CFN92415	176046-04-1	C₂₅H₂₈O₆ = 424.5	5mg	QQ客服：2159513211
甘草黄烷酮; Licoflavanone	CFN95213	119240-82-3	C₂₀H₂₀O₅ = 340.4	5mg	QQ客服：1413575084
4'-O-甲基甘草黄烷酮; 4'-O-Methyllicoflavanone	CFN97958	1038753-13-7	C₂₁H₂₂O₅ = 354.4	5mg	QQ客服：3257982914
桑黄酮E; Kuwanon E	CFN92320	68401-05-8	C₂₅H₂₈O₆ = 424.5	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9377 mL	14.6886 mL	29.3772 mL	58.7544 mL	73.443 mL
5 mM	0.5875 mL	2.9377 mL	5.8754 mL	11.7509 mL	14.6886 mL
10 mM	0.2938 mL	1.4689 mL	2.9377 mL	5.8754 mL	7.3443 mL
50 mM	0.0588 mL	0.2938 mL	0.5875 mL	1.1751 mL	1.4689 mL
100 mM	0.0294 mL	0.1469 mL	0.2938 mL	0.5875 mL	0.7344 mL