(-)-利卡灵B

(-)-Licarin B

	产品编号	CFN99751
	CAS编号	51020-87-2
	分子式 = 分子量	C₂₀H₂₀O₄ = 324.37
	产品纯度	>=98%
	物理属性	White powder
	化合物类型	Lignans
	植物来源	The seeds of Myristica fragrans Houtt.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
(-)-利卡灵B	CFN99751	51020-87-2	3mg	QQ客服：2056216494
(-)-利卡灵B	CFN99751	51020-87-2	6mg	QQ客服：2056216494
(-)-利卡灵B	CFN99751	51020-87-2	9mg	QQ客服：2056216494
(-)-利卡灵B	CFN99751	51020-87-2	12mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Florida A&M University (USA)

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Georgia Institute of Technology (USA)

University of Hull (United Kingdom)

University of Beira Interior (Portugal)

Complutense University of Madrid (Spain)

John Innes Centre (United Kingdom)

Universidad de Antioquia (Colombia)

University of Sao Paulo (Brazil)

CSIRO - Agriculture Flagship (Australia)

University of Canterbury (New Zealand)

Siksha O Anusandhan University (India)

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Description:

Licarin B can improve insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway in 3T3-L1 adipocytes, it as a promising bioactive for insulin resistance and associated complications through its partial PPARγ activity.

Targets:

PPAR | GLUT | PI3K | Akt | IRS-1

In vitro:

Rsc Adv., 2016, 6(83):79859-70.

Licarin B from Myristica fragrans improves insulin sensitivity via PPARγ and activation of GLUT4 in IRS-1/PI3K/AKT pathway in 3T3- L1 adipocytes[Reference: WebLink]

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors regulating lipid and glucose metabolism.
METHODS AND RESULTS:
The objective of the present study is to characterize the cellular effect of Licarin B (LB), a neolignan isolated from Myristica fragrans on the PPARγ and insulin signaling pathways in 3T3-L1 preadipocytes. The molecular mechanism of action of LB on PPARγ and insulin signaling pathways were studied using in vitro and in silico methods. Functional activation of PPARγ in vitro was confirmed by 3T3-L1 preadipocyte differentiation, regulation of target genes and protein expression. LB caused triglyceride accumulation during adipogenesis but significantly less compared to rosiglitazone (RG), a PPARγ full agonist. In in vitro time-resolved fluorescence resonance energy transfer-based competitive binding assay, LB showed an IC50 value of 2.4 μM whereas for RG and GW9662 it was 57.96 nM and 18.68 nM respectively. Virtual screening of LB with PPARγ showed hydrophobic interactions with a binding energy of -9.36 kcal mol⁻1. Interestingly enough LB improved insulin sensitivity by up regulating the GLUT4 expression and translocation via IRS-1/PI3K/AKT pathway, enhanced adiponectin secretion and modulated mRNA expression profile of PPARγ target genes C/EBPα, IRS-2, and LPL significantly compared to RG.
CONCLUSIONS:
This scientifically validate LB as a promising bioactive for insulin resistance and associated complications through its partial PPARγ activity.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Ailanthoidol; Ailanthoidol	CFN89428	156398-61-7	C₁₉H₁₈O₅ = 326.34	5mg	QQ客服：215959384
(-)-白玉兰亭B; 玉兰脂B; Denudatin B	CFN97599	87402-88-8	C₂₁H₂₄O₅ = 356.42	5mg	QQ客服：1413575084
Conocarpan; Conocarpan	CFN98208	221666-27-9	C₁₈H₁₈O₂ = 266.3	5mg	QQ客服：1413575084
Conocarpan acetate; Conocarpan acetate	CFN89302	56319-04-1	C₂₀H₂₀O₃ = 308.37	5mg	QQ客服：215959384
利卡灵A; Licarin A	CFN98244	23518-30-1	C₂₀H₂₂O₄ = 326.4	5mg	QQ客服：215959384
去氢二异丁香酚; Dehydrodiisoeugenol	CFN99750	2680-81-1	C₂₀H₂₂O₄ = 326.39	20mg	QQ客服：2159513211
(-)-利卡灵B; (-)-Licarin B	CFN99751	51020-87-2	C₂₀H₂₀O₄ = 324.37	3mg	QQ客服：2056216494
Odoratisol A; Odoratisol A	CFN90908	891182-93-7	C₂₁H₂₄O₅ = 356.41	5mg	QQ客服：1457312923
粗毛淫羊藿苷; Acuminatin	CFN98656	41744-39-2	C₂₁H₂₄O₄ = 340.4	5mg	QQ客服：3257982914
淫羊藿次甙E5; Icariside E5	CFN99373	126176-79-2	C₂₆H₃₄O₁₁ = 522.6	5mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0829 mL	15.4145 mL	30.829 mL	61.658 mL	77.0725 mL
5 mM	0.6166 mL	3.0829 mL	6.1658 mL	12.3316 mL	15.4145 mL
10 mM	0.3083 mL	1.5414 mL	3.0829 mL	6.1658 mL	7.7072 mL
50 mM	0.0617 mL	0.3083 mL	0.6166 mL	1.2332 mL	1.5414 mL
100 mM	0.0308 mL	0.1541 mL	0.3083 mL	0.6166 mL	0.7707 mL