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  • LY294002

    LY294002

    LY294002
    产品编号 CFN60015
    CAS编号 154447-36-6
    分子式 = 分子量 C19H17NO3 = 307.34
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 Chemical synthesis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    LY294002 CFN60015 154447-36-6 1mg QQ客服:2159513211
    LY294002 CFN60015 154447-36-6 5mg QQ客服:2159513211
    LY294002 CFN60015 154447-36-6 10mg QQ客服:2159513211
    LY294002 CFN60015 154447-36-6 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Bordeaux (France)
  • Anna University (India)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Mahatma Gandhi University (India)
  • University of Malaya (Malaysia)
  • University of Melbourne (Australia)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Helmholtz Zentrum München (Germany)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Korea Institute of Oriental Medicine (Korea)
  • University of Wuerzburg (Germany)
  • University of Pretoria (South Africa)
  • Chungnam National University (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plant J.2021, 107(6):1711-1723.
  • Foods.2021, 10(12):2929.
  • Nat Prod Sci.2016, 22(2)
  • BMC Plant Biol.2023, 23(1):239.
  • Eur Rev Med Pharmacol Sci.2020, 24(9):5127-5139.
  • J Sci Food Agric.2018, 98(3):1153-1161
  • Molecules.2022, 27(22):7887.
  • BioResources J.2020, 15(3).
  • Toxicological Research2020, doi: 10.1007.
  • Natural Product Communications2020, doi: 10.1177.
  • Nutrients.2022, 14(19):4170.
  • Primary and Industrial.2018, 52(11)
  • Natural Product Communications2022, 7(3):1-7.
  • J Nat Prod.2021, 84(9):2544-2553.
  • Int. Conference on Med. Sci. and Bio.2017, 17973
  • Phytomedicine Plus2022, 2(1):100207.
  • LWT-Food Sci Technol2020, 109163
  • J of Physics Conference Series2019, 1349(1)
  • J Pharm Biomed Anal.2018, 151:32-41
  • J Phys Chem Lett.2021, 12(7):1793-1802.
  • Appl. Sci.2022, 12(17), 8646.
  • J Cell Physiol.2021, 236(3):1950-1966.
  • Antioxidants.2022, 11(3):491.
  • ...
  • 生物活性
    Description: LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.
    Targets: CK2 | PI3Kα/δ/β | Autophagy
    In vitro:
    Biochem J. 2007 May 15; 404(Pt 1): 15–21.
    Exploring the specificity of the PI3K family inhibitor LY294002[Pubmed: 17302559]
    The PI3Ks (phosphatidylinositol 3-kinases) regulate cellular signalling networks that are involved in processes linked to the survival, growth, proliferation, metabolism and specialized differentiated functions of cells. The subversion of this network is common in cancer and has also been linked to disorders of inflammation.
    METHODS AND RESULTS:
    The elucidation of the physiological function of PI3K has come from pharmacological studies, which use the enzyme inhibitors Wortmannin and LY294002, and from PI3K genetic knockout models of the effects of loss of PI3K function. Several reports have shown that LY294002 is not exclusively selective for the PI3Ks, and could in fact act on other lipid kinases and additional apparently unrelated proteins. Since this inhibitor still remains a drug of choice in numerous PI3K studies (over 500 in the last year), it is important to establish the precise specificity of this compound. We report here the use of a chemical proteomic strategy in which an analogue of LY294002, PI828, was immobilized onto epoxy-activated Sepharose beads. This affinity material was then used as a bait to fish-out potential protein targets from cellular extracts. Proteins with high affinity for immobilized PI828 were separated by one-dimensional gel electrophoresis and identified by liquid chromatography–tandem MS.
    CONCLUSIONS:
    The present study reveals that LY294002 not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2537 mL 16.2686 mL 32.5373 mL 65.0745 mL 81.3431 mL
    5 mM 0.6507 mL 3.2537 mL 6.5075 mL 13.0149 mL 16.2686 mL
    10 mM 0.3254 mL 1.6269 mL 3.2537 mL 6.5075 mL 8.1343 mL
    50 mM 0.0651 mL 0.3254 mL 0.6507 mL 1.3015 mL 1.6269 mL
    100 mM 0.0325 mL 0.1627 mL 0.3254 mL 0.6507 mL 0.8134 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1,7-Dihydroxy-2,3-dimethoxyxanthone; 1,7-Dihydroxy-2,3-dimethoxyxanthone CFN89239 78405-33-1 C15H12O6 = 288.25 5mg QQ客服:3257982914
    长春花碱; Conophylline CFN99473 142741-24-0 C44H50N4O10 = 794.9 5mg QQ客服:215959384
    戈米辛A; Gomisin A CFN98990 58546-54-6 C23H28O7 = 416.5 20mg QQ客服:2056216494
    1,3,6,8-tetrahydroxy-4-(3-methyl-2-buten-1-yl)-9H-Xanthen-9-one; 1,3,6,8-tetrahydroxy-4-(3-methyl-2-buten-1-yl)-9H-Xanthen-9-one CFN92541 1319198-98-5 C18H16O6 = 328.3 5mg QQ客服:1413575084

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