LY294002
LY294002
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| LY294002 |
CFN60015 |
154447-36-6 |
1mg |
QQ客服：3257982914 |
| LY294002 |
CFN60015 |
154447-36-6 |
5mg |
QQ客服：3257982914 |
| LY294002 |
CFN60015 |
154447-36-6 |
10mg |
QQ客服：3257982914 |
| LY294002 |
CFN60015 |
154447-36-6 |
20mg |
QQ客服：3257982914 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis. |
| Targets: |
CK2 | PI3Kα/δ/β | Autophagy |
| In vitro: |
| Biochem J. 2007 May 15; 404(Pt 1): 15–21. | | Exploring the specificity of the PI3K family inhibitor LY294002[Pubmed: 17302559] | The PI3Ks (phosphatidylinositol 3-kinases) regulate cellular signalling networks that are involved in processes linked to the survival, growth, proliferation, metabolism and specialized differentiated functions of cells. The subversion of this network is common in cancer and has also been linked to disorders of inflammation.
METHODS AND RESULTS:
The elucidation of the physiological function of PI3K has come from pharmacological studies, which use the enzyme inhibitors Wortmannin and LY294002, and from PI3K genetic knockout models of the effects of loss of PI3K function. Several reports have shown that LY294002 is not exclusively selective for the PI3Ks, and could in fact act on other lipid kinases and additional apparently unrelated proteins. Since this inhibitor still remains a drug of choice in numerous PI3K studies (over 500 in the last year), it is important to establish the precise specificity of this compound. We report here the use of a chemical proteomic strategy in which an analogue of LY294002, PI828, was immobilized onto epoxy-activated Sepharose beads. This affinity material was then used as a bait to fish-out potential protein targets from cellular extracts. Proteins with high affinity for immobilized PI828 were separated by one-dimensional gel electrophoresis and identified by liquid chromatography–tandem MS.
CONCLUSIONS:
The present study reveals that LY294002 not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.2537 mL |
16.2686 mL |
32.5373 mL |
65.0745 mL |
81.3431 mL |
| 5 mM |
0.6507 mL |
3.2537 mL |
6.5075 mL |
13.0149 mL |
16.2686 mL |
| 10 mM |
0.3254 mL |
1.6269 mL |
3.2537 mL |
6.5075 mL |
8.1343 mL |
| 50 mM |
0.0651 mL |
0.3254 mL |
0.6507 mL |
1.3015 mL |
1.6269 mL |
| 100 mM |
0.0325 mL |
0.1627 mL |
0.3254 mL |
0.6507 mL |
0.8134 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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