Dihydroxyaflavinine

	产品编号	CFN89093
	CAS编号	76410-56-5
	分子式 = 分子量	C₂₈H₃₉NO₃ = 437.62
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The metabolites of Aspergillus flavus.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Dihydroxyaflavinine	CFN89093	76410-56-5	1mg	QQ客服：3257982914
Dihydroxyaflavinine	CFN89093	76410-56-5	5mg	QQ客服：3257982914
Dihydroxyaflavinine	CFN89093	76410-56-5	10mg	QQ客服：3257982914
Dihydroxyaflavinine	CFN89093	76410-56-5	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
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PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
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PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Medical University of South Carolina (USA)

Rio de Janeiro State University (Brazil)

The University of Newcastle (Australia)

Korea Intitute of Science and Technology (KIST) (Korea)

Julius Kühn-Institut (Germany)

Ain Shams University (Egypt)

Sanford Burnham Prebys Medical Discovery Institute (USA)

Florida International University (USA)

Heidelberg University (Germany)

VIT University (India)

Wroclaw Medical University (Poland)

University of Canterbury (New Zealand)

Complutense University of Madrid (Spain)

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Description:

Dihydroxyaflavinine is a fungal toxin, it inhibits non-competitively GABAA receptor channel expressed in Xenopus oocytes.Dihydroxyaflavinine shows oral toxicity to the fall armyworm (Spodoptera frugiperda) and corn earworm (Heliothis zea).

Targets:

GABA Receptor

In vitro:

Sheng Li Xue Bao. 1991 Jun;43(3):227-35.

Fungal toxin dihydroxyaflavinine inhibits non-competitively GABAA receptor channel expressed in Xenopus oocytes.[Pubmed: 1664974]

Dihydroxyaflavinine is an indole-derived metabolite of Aspergillus flavus.
METHODS AND RESULTS:
Its action on GABA-induced response was quantitatively studied on the GABAA receptor expressed in Xenopus oocytes after injection of chick brain mRNA under voltage-clamp conditions. Dihydroxyaflavinine inhibits GABA-induced current non-competitively with KI = 12 mumol/L. This blockage is rapidly reversible. In comparison, the inhibitory effect of penicillin on GABAA receptor is enhanced by increasing GABA concentration. Ro 15-1788 (a benzodiazepine ligand with KD = 0.6--2 nmol/L) of concentration as high as 1 mumol/L, does not mask the action of 10 mumol/L Dihydroxyaflavinine, indicating that Dihydroxyaflavinine acts on a site different from benzodiazepines.
CONCLUSIONS:
Dihydroxyaflavinine appears to expedite desensitization of the receptor, which is similar to the action of picrotoxin and in contrast with that of penicillin and bicuculline.

J Antibiot (Tokyo). 1988 Dec;41(12):1868-72.

Toxicity of selected tremorgenic mycotoxins and related compounds to Spodoptera frugiperda and Heliothis zea.[Pubmed: 3209479]

METHODS AND RESULTS:
A series of tremorgenic mycotoxins and related compounds were tested for oral toxicity to the fall armyworm (Spodoptera frugiperda) and corn earworm (Heliothis zea) by incorporation of materials into artificial diets and examining mortality and weights after 7 days. Significant mortality to both insect species was caused with Dihydroxyaflavinine and roseotoxin B, while significant mortality to H. zea was also caused by penitrem A at 25 ppm. After 7 days, weighs of larvae treated with 25 ppm penitrem A, roseotoxin B, and verruculogen were less than 50% of controls for both insect species. Weights of H. zea larvae treated with 25 ppb of penitrem A were less than 50% those of control larvae. Relative toxicities of the tremorgens and related compounds to insects compared to vertebrates are discussed.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2851 mL	11.4254 mL	22.8509 mL	45.7018 mL	57.1272 mL
5 mM	0.457 mL	2.2851 mL	4.5702 mL	9.1404 mL	11.4254 mL
10 mM	0.2285 mL	1.1425 mL	2.2851 mL	4.5702 mL	5.7127 mL
50 mM	0.0457 mL	0.2285 mL	0.457 mL	0.914 mL	1.1425 mL
100 mM	0.0229 mL	0.1143 mL	0.2285 mL	0.457 mL	0.5713 mL