Dihydroxyaflavinine

	产品编号	CFN89093
	CAS编号	76410-56-5
	分子式 = 分子量	C₂₈H₃₉NO₃ = 437.62
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The metabolites of Aspergillus flavus.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
Dihydroxyaflavinine	CFN89093	76410-56-5	1mg	QQ客服：215959384
Dihydroxyaflavinine	CFN89093	76410-56-5	5mg	QQ客服：215959384
Dihydroxyaflavinine	CFN89093	76410-56-5	10mg	QQ客服：215959384
Dihydroxyaflavinine	CFN89093	76410-56-5	20mg	QQ客服：215959384

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Warszawski Uniwersytet Medyczny (Poland)

Seoul National University (Korea)

Universiti Sains Malaysia (Malaysia)

Universidad de La Salle (Mexico)

University of Bordeaux (France)

University of British Columbia (Canada)

University of Bonn (Germany)

FORTH-IMBB (Greece)

Universita' Degli Studi Di Cagliari (Italy)

Center for protein Engineering (CIP) (Belgium)

Centralised Purchases Unit (CPU), B.I.T.S (India)

University of South Australia (Australia)

Shanghai University of TCM (China)

Uniwersytet Medyczny w ?odzi (Poland)

More...

Description:

Dihydroxyaflavinine is a fungal toxin, it inhibits non-competitively GABAA receptor channel expressed in Xenopus oocytes.Dihydroxyaflavinine shows oral toxicity to the fall armyworm (Spodoptera frugiperda) and corn earworm (Heliothis zea).

Targets:

GABA Receptor

In vitro:

Sheng Li Xue Bao. 1991 Jun;43(3):227-35.

Fungal toxin dihydroxyaflavinine inhibits non-competitively GABAA receptor channel expressed in Xenopus oocytes.[Pubmed: 1664974]

Dihydroxyaflavinine is an indole-derived metabolite of Aspergillus flavus.
METHODS AND RESULTS:
Its action on GABA-induced response was quantitatively studied on the GABAA receptor expressed in Xenopus oocytes after injection of chick brain mRNA under voltage-clamp conditions. Dihydroxyaflavinine inhibits GABA-induced current non-competitively with KI = 12 mumol/L. This blockage is rapidly reversible. In comparison, the inhibitory effect of penicillin on GABAA receptor is enhanced by increasing GABA concentration. Ro 15-1788 (a benzodiazepine ligand with KD = 0.6--2 nmol/L) of concentration as high as 1 mumol/L, does not mask the action of 10 mumol/L Dihydroxyaflavinine, indicating that Dihydroxyaflavinine acts on a site different from benzodiazepines.
CONCLUSIONS:
Dihydroxyaflavinine appears to expedite desensitization of the receptor, which is similar to the action of picrotoxin and in contrast with that of penicillin and bicuculline.

J Antibiot (Tokyo). 1988 Dec;41(12):1868-72.

Toxicity of selected tremorgenic mycotoxins and related compounds to Spodoptera frugiperda and Heliothis zea.[Pubmed: 3209479]

METHODS AND RESULTS:
A series of tremorgenic mycotoxins and related compounds were tested for oral toxicity to the fall armyworm (Spodoptera frugiperda) and corn earworm (Heliothis zea) by incorporation of materials into artificial diets and examining mortality and weights after 7 days. Significant mortality to both insect species was caused with Dihydroxyaflavinine and roseotoxin B, while significant mortality to H. zea was also caused by penitrem A at 25 ppm. After 7 days, weighs of larvae treated with 25 ppm penitrem A, roseotoxin B, and verruculogen were less than 50% of controls for both insect species. Weights of H. zea larvae treated with 25 ppb of penitrem A were less than 50% those of control larvae. Relative toxicities of the tremorgens and related compounds to insects compared to vertebrates are discussed.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
去甲肾上腺素; Norepinephrine	CFN90047	51-41-2	C₈H₁₁NO₃ = 169.18	20mg	QQ客服：3257982914
3-羟基根皮苷; Sieboldin	CFN70294	18777-73-6	C₂₁H₂₄O₁₁ = 452.4	5mg	QQ客服：1457312923
松属素；乔松素; Pinocembrin	CFN98740	480-39-7	C₁₅H₁₂O₄ = 256.3	20mg	QQ客服：2056216494
Obscuraminol D; Obscuraminol D	CFN00040	350484-99-0	C₁₆H₃₃NO = 255.44	5mg	QQ客服：2056216494

信息支持

公司简介
订购流程
付款方式
退换货政策

ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

联系方式

电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com

湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2851 mL	11.4254 mL	22.8509 mL	45.7018 mL	57.1272 mL
5 mM	0.457 mL	2.2851 mL	4.5702 mL	9.1404 mL	11.4254 mL
10 mM	0.2285 mL	1.1425 mL	2.2851 mL	4.5702 mL	5.7127 mL
50 mM	0.0457 mL	0.2285 mL	0.457 mL	0.914 mL	1.1425 mL
100 mM	0.0229 mL	0.1143 mL	0.2285 mL	0.457 mL	0.5713 mL