曲酸

Kojic acid

	产品编号	CFN94478
	CAS编号	501-30-4
	分子式 = 分子量	C₆H₆O₄ = 142.11
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Miscellaneous
	植物来源	From the Aspergillus parasiticus.
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产品名称	产品编号	CAS编号	包装	QQ客服
曲酸	CFN94478	501-30-4	10mg	QQ客服：2056216494
曲酸	CFN94478	501-30-4	20mg	QQ客服：2056216494
曲酸	CFN94478	501-30-4	50mg	QQ客服：2056216494
曲酸	CFN94478	501-30-4	100mg	QQ客服：2056216494

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Description:

Kojic acid has been used as a food additive for preventing enzymatic browning of crustaceans and as a cosmetic agent for skin whitening. Kojic acid exhibits concentration-dependent scavenging activity on DPPH possessing strong antioxidant activity, it can reduce the mortality induced by gamma irradiation; it exhibits a competitive inhibition for the oxidation of chlorogenic acid and catechol by potato polyphenol oxidase (PPO) and of 4-methylcatechol and chlorogenic acid by apple PPO; it also has significant tyrosinase inhibitory activity.

Targets:

Tyrosinase

In vitro:

J Pharm Pharmacol. 1994 Dec;46(12):982-5.

Kojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase.[Pubmed: 7714722]

METHODS AND RESULTS:
It was found that kojic acid, which is used in cosmetics for its excellent whitening effect, inhibits catecholase activity of tyrosinase in a non-classical manner. A decrease in the initial velocity to a steady-state inhibited velocity can be observed over a few minutes. This time-dependence, which is unaltered by prior incubation of the enzyme with the inhibitor, is consistent with a first-order transition.
CONCLUSIONS:
The kinetic data obtained correspond to those for a postulated mechanism that involves the rapid formation of an enzyme inhibitor complex that subsequently undergoes a relatively slow reversible reaction. Kinetic parameters characterizing this type of inhibition were evaluated by means of nonlinear regression of product accumulation curves.

In vivo:

Toxicol Sci. 2004 Sep;81(1):43-9.

Enhancement of hepatocarcinogenesis by kojic acid in rat two-stage models after initiation with N-bis(2-hydroxypropyl)nitrosamine or N-diethylnitrosamine.[Pubmed: 15201437]

Kojic acid (KA) has been used as a food additive for preventing enzymatic browning of crustaceans and as a cosmetic agent for skin whitening.
METHODS AND RESULTS:
In the present experiments, effects of KA on the induction of hepatic pre-neoplastic lesions in N-bis(2-hydroxypropyl)nitrosamine-initiated (experiment 1) and non-initiated (experiment 2) models, and its promoting influence in a medium-term liver bioassay (experiment 3) were investigated at dietary doses of up to 2% in male F344 rats. In experiment 1, 2% KA feeding induced significant increases in numbers (22.3 +/- 13.0 vs 8.5 +/- 3.4 in the 0%) and areas (0.37 +/- 0.29 vs 0.05 +/- 0.03 in the 0%) of glutathione-S-transferase P form (GST-P)-positive foci and toxic changes such as vacuolation of hepatocytes and microgranulomas. The development of GST-P-positive foci was pronounced in the animals with hepatocellular toxic changes. In experiment 2, numbers (0.65 +/- 0.57 vs 0.17 +/- 0.28 in the 0%) and areas (0.005 +/- 0.005 vs 0.0007 +/- 0.0012 in the 0%) of GST-P-positive foci and hepatocellular proliferating cell nuclear antigen (PCNA) expression (3.8 +/- 2.3 vs 2.6 +/- 0.7 in the 0%) were significantly increased by the 2% treatment. The PCNA-positive hepatocytes were abundantly localized around the vacuolated and granulomatous legions in both experiments 1 and 2. In experiment 3, significant increases in numbers (16.9 +/- 3.2 vs 8.4 +/- 2.7 in the 0%) and areas (1.62 +/- 0.39 vs 0.77 +/- 0.34 in the 0%) of GST-P-positive foci were again observed with 2% KA.
CONCLUSIONS:
These results demonstrate tumor-promoting and possible hepatocarcinogenic activity of KA at 2%, but the carcinogenic potential is likely to be weak. This study also indicated that enhanced replication of hepatocytes related to toxic changes might be involved as an underlying mechanism.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Eriosematin A; Eriosematin A	CFN92552	175448-02-9	C₁₄H₁₄O₄ = 246.3	5mg	QQ客服：3257982914
Eriosemation; Eriosemation	CFN92835	162616-72-0	C₁₉H₂₂O₄ = 314.4	5mg	QQ客服：3257982914
麦芽酚; Maltol	CFN97949	118-71-8	C₆H₆O₃ = 126.1	20mg	QQ客服：1457312923
5-Hydroxymaltol 3-O-beta-D-glucoside; 5-Hydroxymaltol 3-O-beta-D-glucoside	CFN95641	N/A	C₁₂H₁₆O₉ = 304.3	10mg	QQ客服：2056216494
曲酸; Kojic acid	CFN94478	501-30-4	C₆H₆O₄ = 142.11	20mg	QQ客服：215959384
白屈菜酸; Chelidonic acid	CFN94111	99-32-1	C₇H₄O₆ = 184.10	20mg	QQ客服：2159513211
去甲氧基茵陈色原酮; Demethoxycapillarisin	CFN97716	61854-36-2	C₁₅H₁₀O₆ = 286.24	5mg	QQ客服：1413575084
7-O-去甲氧基茵陈色原酮; Demethoxy-7-O-methylcapillarisin	CFN96209	61854-37-3	C₁₆H₁₂O₆ = 300.3	5mg	QQ客服：1457312923
茵陈色原酮; Capillarisin	CFN90317	56365-38-9	C₁₆H₁₂O₇ = 316.26	5mg	QQ客服：215959384
Epimedonin B; Epimedonin B	CFN92907	1616061-69-8	C₂₀H₁₆O₆ = 352.34	5mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	7.0368 mL	35.184 mL	70.368 mL	140.736 mL	175.9201 mL
5 mM	1.4074 mL	7.0368 mL	14.0736 mL	28.1472 mL	35.184 mL
10 mM	0.7037 mL	3.5184 mL	7.0368 mL	14.0736 mL	17.592 mL
50 mM	0.1407 mL	0.7037 mL	1.4074 mL	2.8147 mL	3.5184 mL
100 mM	0.0704 mL	0.3518 mL	0.7037 mL	1.4074 mL	1.7592 mL

曲酸

Kojic acid

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