顺式-(+)-凯林内酯
Khellactone
|
|
产品编号 |
CFN96394 |
| CAS编号 |
24144-61-4 |
| 分子式 = 分子量 |
C14H14O5 = 262.3 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Coumarins |
| 植物来源 |
The roots of Angelica purpuraefolia. |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 顺式-(+)-凯林内酯 |
CFN96394 |
24144-61-4 |
1mg |
QQ客服：1457312923 |
| 顺式-(+)-凯林内酯 |
CFN96394 |
24144-61-4 |
5mg |
QQ客服：1457312923 |
| 顺式-(+)-凯林内酯 |
CFN96394 |
24144-61-4 |
10mg |
QQ客服：1457312923 |
| 顺式-(+)-凯林内酯 |
CFN96394 |
24144-61-4 |
20mg |
QQ客服：1457312923 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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Chinese University of Hong Kong (China)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Khellactone shows antitumor activity,it can suppress the growth of NCI-H460 tumor cells. (+)-4'-cis-Khellactone and (+)-3'-cis-khellactone have antiplasmodial activities, they show notable inhibitory activity against -sensitive strains of with IC(50) values from 1.5 and 2.4 microM. |
| Targets: |
Antifection |
| In vitro: |
| Phytother Res. 2010 Mar;24(3):469-71. | | Antiplasmodial and cytotoxic activity of khellactone derivatives from Angelica purpuraefolia Chung.[Pubmed: 19960419 ] | The methanolic extract of the rhizomes parts of Agelica purpuraefolia was investigated for its activity against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method.
METHODS AND RESULTS:
Two natural khellactone, (+)-4'-Decanoyl-cis-khellactone (1) and (+)-3'-Decanoyl-cis-khellactone (2) were isolated from the rhizomes parts of A. purpuraefolia. Two compounds were evaluated for in vitro antiplasmodial activities as well as their cytotoxic potential on SK-OV-3 cancer cell line cells. Compounds 1, 2 showed notable growth inhibitory activity against chloroquine-sensitive strains of Plasmodium falciparum with IC(50) values from 1.5 and 2.4 microM. This compound showed no significant cytotoxicity (IC(50) > 100 microM) evaluated using SK-OV-3 cancer cell line cells.
CONCLUSIONS:
This is the first report on the antiplasmodial activity of the compounds from A. purpuraefolia. |
|
| In vivo: |
| Phytother Res. 2007 May;21(5):406-9. | | Isolation of coumarins and ferulate from the roots of Angelica purpuraefolia and the antitumor activity of khellactone.[Pubmed: 17236175 ] | A new coumarin, hydroxylomatin (1), was isolated from the CHCl(3)-soluble fraction of the roots of Angelica purpuraefolia, along with one ferulate (2) and three other known coumarins (3-5) including Khellactone (3). The structure of hydroxylomatin (1) was determined to be 3'beta,5'-dihydroxy-3',4'-dihydroseselin (1) by spectroscopic means including 2D-NMR. The modified Mosher's method was used to determine the chiral center at C-1 of compound 2. Khellactone (3) is a major compound of the roots of A. purpuraefolia.
METHODS AND RESULTS:
This study also examined the antitumor activity of Khellactone (3) using a LLC mouse lung carcinoma in the BDF-1 mice and a NCI-H460 human lung carcinoma in a human tumor xenograft model in nude mice. This compound (3) inhibited LLC tumor growth with a T/C (mean value of treated group/mean value of control group) value of 12.9% at a dose of 5 mg/kg and 33.2% at a dose of 10 mg/kg, respectively, in a dose-dependent manner. In addition, it suppressed the growth of NCI-H460 tumor cells, accounting for 81.4% at a dose of 10 mg/kg in nude mice. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.8124 mL |
19.0621 mL |
38.1243 mL |
76.2486 mL |
95.3107 mL |
| 5 mM |
0.7625 mL |
3.8124 mL |
7.6249 mL |
15.2497 mL |
19.0621 mL |
| 10 mM |
0.3812 mL |
1.9062 mL |
3.8124 mL |
7.6249 mL |
9.5311 mL |
| 50 mM |
0.0762 mL |
0.3812 mL |
0.7625 mL |
1.525 mL |
1.9062 mL |
| 100 mM |
0.0381 mL |
0.1906 mL |
0.3812 mL |
0.7625 mL |
0.9531 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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