顺式-(+)-凯林内酯

Khellactone

	产品编号	CFN96394
	CAS编号	24144-61-4
	分子式 = 分子量	C₁₄H₁₄O₅ = 262.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Coumarins
	植物来源	The roots of Angelica purpuraefolia.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
顺式-(+)-凯林内酯	CFN96394	24144-61-4	1mg	QQ客服：1457312923
顺式-(+)-凯林内酯	CFN96394	24144-61-4	5mg	QQ客服：1457312923
顺式-(+)-凯林内酯	CFN96394	24144-61-4	10mg	QQ客服：1457312923
顺式-(+)-凯林内酯	CFN96394	24144-61-4	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Biotech R&D Institute (USA)

The University of Newcastle (Australia)

Agricultural Research Organization (ARO) (Israel)

Sanford Burnham Medical Research Institute (USA)

Ain Shams University (Egypt)

Korea Institute of Oriental Medicine (Korea)

University of Leipzig (Germany)

Cancer Research Initatives Foundation(CARIF) (Malaysia)

University of Oslo (Norway)

Srinakharinwirot University (Thailand)

Universidad Industrial de Santander (Colombia)

Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)

Universidad de Buenos Aires (Argentina)

VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)

More...

Description:

Khellactone shows antitumor activity,it can suppress the growth of NCI-H460 tumor cells. (+)-4'-cis-Khellactone and (+)-3'-cis-khellactone have antiplasmodial activities, they show notable inhibitory activity against -sensitive strains of with IC(50) values from 1.5 and 2.4 microM.

Targets:

Antifection

In vitro:

Phytother Res. 2010 Mar;24(3):469-71.

Antiplasmodial and cytotoxic activity of khellactone derivatives from Angelica purpuraefolia Chung.[Pubmed: 19960419 ]

The methanolic extract of the rhizomes parts of Agelica purpuraefolia was investigated for its activity against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method.
METHODS AND RESULTS:
Two natural khellactone, (+)-4'-Decanoyl-cis-khellactone (1) and (+)-3'-Decanoyl-cis-khellactone (2) were isolated from the rhizomes parts of A. purpuraefolia. Two compounds were evaluated for in vitro antiplasmodial activities as well as their cytotoxic potential on SK-OV-3 cancer cell line cells. Compounds 1, 2 showed notable growth inhibitory activity against chloroquine-sensitive strains of Plasmodium falciparum with IC(50) values from 1.5 and 2.4 microM. This compound showed no significant cytotoxicity (IC(50) > 100 microM) evaluated using SK-OV-3 cancer cell line cells.
CONCLUSIONS:
This is the first report on the antiplasmodial activity of the compounds from A. purpuraefolia.

In vivo:

Phytother Res. 2007 May;21(5):406-9.

Isolation of coumarins and ferulate from the roots of Angelica purpuraefolia and the antitumor activity of khellactone.[Pubmed: 17236175 ]

A new coumarin, hydroxylomatin (1), was isolated from the CHCl(3)-soluble fraction of the roots of Angelica purpuraefolia, along with one ferulate (2) and three other known coumarins (3-5) including Khellactone (3). The structure of hydroxylomatin (1) was determined to be 3'beta,5'-dihydroxy-3',4'-dihydroseselin (1) by spectroscopic means including 2D-NMR. The modified Mosher's method was used to determine the chiral center at C-1 of compound 2. Khellactone (3) is a major compound of the roots of A. purpuraefolia.
METHODS AND RESULTS:
This study also examined the antitumor activity of Khellactone (3) using a LLC mouse lung carcinoma in the BDF-1 mice and a NCI-H460 human lung carcinoma in a human tumor xenograft model in nude mice. This compound (3) inhibited LLC tumor growth with a T/C (mean value of treated group/mean value of control group) value of 12.9% at a dose of 5 mg/kg and 33.2% at a dose of 10 mg/kg, respectively, in a dose-dependent manner. In addition, it suppressed the growth of NCI-H460 tumor cells, accounting for 81.4% at a dose of 10 mg/kg in nude mice.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
(-)-白花前胡素 B; (-)-Praeruptorin B	CFN89387	4970-26-7	C₂₄H₂₆O₇ = 426.45	5mg	QQ客服：1413575084
丝立尼亭; Selinidin	CFN90570	19427-82-8	C₁₉H₂₀O₅ = 328.4	5mg	QQ客服：1413575084
前胡香豆精E; Qianhucoumarin E	CFN92597	156041-02-0	C₁₉H₁₈O₆ = 342.4	5mg	QQ客服：215959384
前胡香豆精 A; Qianhucoumarin A	CFN92709	150135-35-6	C₁₉H₂₀O₆ = 344.4	5mg	QQ客服：215959384
顺式-(+)-凯林内酯; Khellactone	CFN96394	24144-61-4	C₁₄H₁₄O₅ = 262.3	5mg	QQ客服：2159513211
顺式-甲基凯诺内酯; cis-Methylkhellactone	CFN89413	20107-13-5	C₁₅H₁₆O₅ = 276.28	5mg	QQ客服：2056216494
Praeroside II; Praeroside II	CFN96695	86940-46-7	C₂₀H₂₄O₁₀ = 424.40	5mg	QQ客服：1457312923
(+)-沙米丁; Samidin	CFN96375	477-33-8	C₂₁H₂₂O₇ = 386.4	5mg	QQ客服：2056216494
Hyuganin D; Hyuganin D	CFN89402	77331-76-1	C₂₀H₂₂O₇ = 374.38	5mg	QQ客服：1457312923
(-)-白花前胡素 A; (-)-Praeruptorin A	CFN89386	14017-71-1	C₂₁H₂₂O₇ = 386.39	5mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.8124 mL	19.0621 mL	38.1243 mL	76.2486 mL	95.3107 mL
5 mM	0.7625 mL	3.8124 mL	7.6249 mL	15.2497 mL	19.0621 mL
10 mM	0.3812 mL	1.9062 mL	3.8124 mL	7.6249 mL	9.5311 mL
50 mM	0.0762 mL	0.3812 mL	0.7625 mL	1.525 mL	1.9062 mL
100 mM	0.0381 mL	0.1906 mL	0.3812 mL	0.7625 mL	0.9531 mL

顺式-(+)-凯林内酯

Khellactone

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