醉椒素
Kawain
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 醉椒素 |
CFN92656 |
500-64-1 |
10mg |
QQ客服：1413575084 |
| 醉椒素 |
CFN92656 |
500-64-1 |
20mg |
QQ客服：1413575084 |
| 醉椒素 |
CFN92656 |
500-64-1 |
50mg |
QQ客服：1413575084 |
| 醉椒素 |
CFN92656 |
500-64-1 |
100mg |
QQ客服：1413575084 |
1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。
2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。 但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常，这些可用于长达两周。 使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。
3. 需要更多关于溶解度，使用和处理的建议？ 请发送电子邮件至：service@chemfaces.com
订购流程
1. 在线订购
请联系我们QQ客服
2. 电话订购
请拨打电话：
027-84237683 或 027-84237783
3. 邮件或传真订购
发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680
提供订购信息
为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。
1. 产品编号（CAS No.或产品名称）
2. 发货地址
3. 联系方法 (联系人，电话）
4. 开票抬头 (如果需要发票的客户）
5. 发票地址（发货地址与发票地址不同）
发货时间
1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。
2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。
3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。
ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
Korea Food Research Institute(KFRI) (Korea)
Max Rubner-Institut (MRI) (Germany)
Warszawski Uniwersytet Medyczny (Poland)
Uniwersytet Gdański (Poland)
Monash University (Australia)
Centralised Purchases Unit (CPU), B.I.T.S (India)
Universidade Federal de Pernambuco (UFPE) (Brazil)
Instytut Nawozów Sztucznych w Pu?awach (Poland)
University of Minnesota (USA)
Universidad de Ciencias y Artes de Chiapas (Mexico)
Wageningen University (Netherlands)
University of Lodz (Poland)
University of Illinois (USA)
Kazusa DNA Research Institute (Japan)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Kavain has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. Kawain is advanced glycation endproduct inhibitors, can increase the mean life span of Caenorhabditis elegans exposed to high glucose. |
| Targets: |
NMDAR |
| In vitro: |
| Prog Neuropsychopharmacol Biol Psychiatry. 1997 May;21(4):697-706. | | Effects of kawain and dihydromethysticin on field potential changes in the hippocampus.[Pubmed: 9194150] | 1. The kava-pyrones Kawain and dihydromethysticin are constituents of Piper methysticum which exert anticonvulsant, analgesic and anxiolytic properties.
METHODS AND RESULTS:
3. Kawain and dihydromethysticin reduced reversibly the frequency of occurrence of fp in a concentration range from 5 to 40 mumol/l and 10 to 40 mumol/l, respectively. 4. Reduction of the fp frequency after addition of subthreshold concentrations of 5 mumol/l Kawain and 10 mumol/l dihydromethysticin indicated additive actions of both drugs. 5. Since the serotonin-1A agonist ipsapirone also exerts anxiolytic effects, subthreshold concentrations of Kawain or dihydromethysticin were combined with a subthreshold concentration of ipsapirone in another set of experiments. Combining Kawain and ipsapirone or dihydromethysticin and ipsapirone caused a reduction of the rate of fp to 0.76 and 0.81 of the baseline value, respectively.
CONCLUSIONS:
6. The findings suggest that (i) single constituents of Piper methysticum may have additive actions, (ii) that the two components Kawain and dihydromethysticin may enhance the effects of the anxiolytic serotonin-1A agonist ipsapirone and (iii) that activation of NMDA receptors and/or voltage dependent calcium channels may be involved in the elementary mechanism of action of some kava-pyrones. |
|
| In vivo: |
| Drug Metab Dispos. 2005 Oct;33(10):1555-63. | | Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract and kavalactones in vivo and in vitro.[Pubmed: 16033948] |
METHODS AND RESULTS:
The oral pharmacokinetics of the kavalactone, Kawain (100 mg/kg), were determined in rats with and without coadministration of kava extract (256 mg/kg) to study the effect of the extract on drug disposition. Kawain was well absorbed, with >90% of the dose eliminated within 72 h, chiefly in urine. Compared with Kawain alone, coadministration with kava extract caused a tripling of Kawain AUC(0-8 h) and a doubling of C(max). However, a 7-day pretreatment with kava extract (256 mg /kg/day) had no effect on the pharmacokinetics of Kawain administered on day 8.
CONCLUSIONS:
The 7-day pretreatment with kava extract only modestly induced hepatic P450 activities. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
4.3422 mL |
21.7108 mL |
43.4216 mL |
86.8432 mL |
108.5541 mL |
| 5 mM |
0.8684 mL |
4.3422 mL |
8.6843 mL |
17.3686 mL |
21.7108 mL |
| 10 mM |
0.4342 mL |
2.1711 mL |
4.3422 mL |
8.6843 mL |
10.8554 mL |
| 50 mM |
0.0868 mL |
0.4342 mL |
0.8684 mL |
1.7369 mL |
2.1711 mL |
| 100 mM |
0.0434 mL |
0.2171 mL |
0.4342 mL |
0.8684 mL |
1.0855 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
部分图片展示
联系方式
电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com
湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房
ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证
天然化合物与对照品的研发和生产。
