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  • 卡枯醇

    Kakuol

    卡枯醇
    产品编号 CFN93222
    CAS编号 18607-90-4
    分子式 = 分子量 C10H10O4 = 194.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The roots of Asarum sieboldii Miq.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    卡枯醇 CFN93222 18607-90-4 10mg QQ客服:2159513211
    卡枯醇 CFN93222 18607-90-4 20mg QQ客服:2159513211
    卡枯醇 CFN93222 18607-90-4 50mg QQ客服:2159513211
    卡枯醇 CFN93222 18607-90-4 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Liège (Belgium)
  • Weizmann Institute of Science (Israel)
  • Universidade Federal de Santa Catarina (Brazil)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • University of Virginia (USA)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Biotech R&D Institute (USA)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Calcutta University (India)
  • The Institute of Cancer Research (United Kingdom)
  • Colorado State University (USA)
  • Cornell University (USA)
  • Universit?t Basel (Switzerland)
  • Chiang Mai University (Thailand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Korean Soc Food Sci Nutr2023, 52(11):1101-1110
  • Chem Biol Interact.2020, 328:109200.
  • Arabian Journal of Chemistry2024, 17(3):105648
  • iScience.2023, 26(9):107602.
  • Food Bioscience2023, 52:102412
  • Industrial Crops and Products2019, 140:111612
  • J Appl Toxicol.2020, 40(7):965-978.
  • Pharmaceuticals (Basel).2021, 14(8):742.
  • Chin Med.2022, 17(1):66.
  • Biochem Pharmacol.2020, 178:114083
  • Metabolites.2023, 13(5):625.
  • Evidence-based Compl.&Alternative Med.2023, 5417813
  • J Sep Sci.2021, 44(22):4064-4081.
  • Int J Mol Sci.2018, 19(9):E2601
  • Anticancer Agents Med Chem.2023, 23(10):1204-1210.
  • Forensic Sci Int.2022, 341:111475.
  • Research on Crops.2017, 18(2)
  • J Appl Biol Chem.2024, 67:46-53.
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • Anal Biochem.2019, 569:10-15
  • Separation Science Plus2022, sscp.202200048.
  • Front Immunol.2017, 8:1542
  • J Nat Prod.2023, 86(2):264-275.
  • ...
  • 生物活性
    Description: Kakuol has antifungal activity, it can completely inhibit the mycelial growth of Botrytis cinerea Pers ex Fr and Cladosporium cucumerinum Ellis & Arthur at 50 microg ml(-1) and 30 microg ml(-1), respectively. Kakuol and a derivative analogue are able to inhibit the DNA relaxation mediated by the human enzyme.
    Targets: Topoisomerase | Antifection
    In vitro:
    Pest Manag. Sci., 2005, 61(8):821-5.
    Isolation and antifungal activity of kakuol, a propiophenone derivative from Asarum sieboldii rhizome.[Pubmed: 15846774 ]

    METHODS AND RESULTS:
    An antifungal substance active against Colletotrichum orbiculare (Berk & Mont) Arx was isolated from the methanol extracts of Asarum sieboldii (Miq) Maek rhizomes. High-resolution MS, NMR and UV spectral data confirmed that the antifungal substance is Kakuol, 2-hydroxy-4,5-methylenedioxypropiophenone. Colletotrichum orbiculare was most sensitive to Kakuol, with MIC of 10 microg ml(-1). Kakuol also completely inhibited the mycelial growth of Botrytis cinerea Pers ex Fr and Cladosporium cucumerinum Ellis & Arthur at 50 microg ml(-1) and 30 microg ml(-1), respectively. However, no antimicrobial activity was found against yeast and bacteria even at 100 microg ml(-1). Kakuol exhibited a protective activity against the development of anthracnose disease on cucumber plants. The control efficacy of Kakuol against the anthracnose disease was in general somewhat less than that of the commercial fungicide chlorothalonil.
    CONCLUSIONS:
    This is the first report to demonstrate in vitro and in vivo antifungal activity of Kakuol against C. orbiculare infection.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.1493 mL 25.7467 mL 51.4933 mL 102.9866 mL 128.7333 mL
    5 mM 1.0299 mL 5.1493 mL 10.2987 mL 20.5973 mL 25.7467 mL
    10 mM 0.5149 mL 2.5747 mL 5.1493 mL 10.2987 mL 12.8733 mL
    50 mM 0.103 mL 0.5149 mL 1.0299 mL 2.0597 mL 2.5747 mL
    100 mM 0.0515 mL 0.2575 mL 0.5149 mL 1.0299 mL 1.2873 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (2R)-3-Hydroxy-2-[4-(3-hydroxypropyl)-2- methoxyphenoxy]propyl beta-D-glucopyranoside; (2R)-3-Hydroxy-2-[4-(3-hydroxypropyl)-2- methoxyphenoxy]propyl beta-D-glucopyranoside CFN95644 198817-97-9 C19H30O10 = 418.4 5mg QQ客服:1457312923
    (2S)-3-Hydroxy-2-[4-(3-hydroxypropyl)-2- methoxyphenoxy]propyl beta-D-glucopyranoside; (2S)-3-Hydroxy-2-[4-(3-hydroxypropyl)-2- methoxyphenoxy]propyl beta-D-glucopyranoside CFN95645 198817-98-0 C19H30O10 = 418.4 5mg QQ客服:2159513211
    (1R,2R)-REL-1-(4-羟基-3-甲氧基苯基)-1,2-丙二醇 erythro; threo-1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol CFN96100 848031-94-7 C10H14O4 = 198.2 5mg QQ客服:3257982914
    (1R,2S)-REL-1-(4-羟基-3-甲氧基苯基)-1,2-丙二醇; erythro-1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol CFN96099 1280602-81-4 C10H14O4 = 198.2 5mg QQ客服:3257982914
    苏式-愈创木基甘油; threo-Guaiacylglycerol CFN98327 27391-16-8 C10H14O5 = 214.2 5mg QQ客服:1413575084
    赤式-愈创木基甘油; erythro-Guaiacylglycerol CFN98619 38916-91-5 C10H14O5 = 214.2 5mg QQ客服:1413575084
    C-藜芦酰乙二醇; C-Veratroylglycol CFN99804 168293-10-5 C10H12O5 = 212.2 5mg QQ客服:2159513211
    甲基丁香酚乙二醇; Methyleugenolglycol CFN96264 26509-45-5 C11H16O4 = 212.2 5mg QQ客服:3257982914
    苏式-1-C-丁香酚基丙三醇; threo-1-C-Syringylglycerol CFN99336 121748-11-6 C11H16O6 = 244.2 5mg QQ客服:1457312923
    2,3,4’-三羟基-3’,5’-二甲氧基苯丙酮; 2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone CFN98436 33900-74-2 C11H14O6 = 242.2 5mg QQ客服:215959384

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