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  • 山奈酚葡萄糖醛酸苷

    • 山奈酚葡萄糖醛酸苷

    Kaempferol-3-beta-O-glucuronide

    山奈酚葡萄糖醛酸苷
    		产品编号 CFN90359
    CAS编号 22688-78-4
    分子式 = 分子量 C21H18O12 = 462.36
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Euphorbia lathyris
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    山奈酚葡萄糖醛酸苷 CFN90359 22688-78-4 1mg QQ客服：1413575084
    山奈酚葡萄糖醛酸苷 CFN90359 22688-78-4 5mg QQ客服：1413575084
    山奈酚葡萄糖醛酸苷 CFN90359 22688-78-4 10mg QQ客服：1413575084
    山奈酚葡萄糖醛酸苷 CFN90359 22688-78-4 20mg QQ客服：1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • The Vancouver Prostate Centre (VPC) (Canada)
  • University of Madras (India)
  • Sanford Burnham Medical Research Institute (USA)
  • University of Brasilia (Brazil)
  • Chinese University of Hong Kong (China)
  • Michigan State University (USA)
  • National Research Council of Canada (Canada)
  • Osmania University (India)
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  • Harvard University (USA)
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  • Istanbul University (Turkey)
  • Institute of Chinese Materia Medica (China)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J.Korean Society of Grassland&Forage Science2023, 43(3):138-147.
  • Metabolites.2023, 13(6):689.
  • Phytomedicine.2020, 153440.
  • Nutrients2020, 12(3):811.
  • Appl. Sci.2020, 10(4),1304
  • Research on Crops.2017, 18(3):569
  • PLoS One.2017, 12(8):e0181191
  • Universidade Estadual Paulista2017, 42785
  • Int J Mol Sci.2021, 22(11):5503.
  • J Cell Mol Med.2023, 27(11):1592-1602.
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • Phytomedicine.2022, 99:153997.
  • Molecules. 2013, 18(7):7376-88
  • Front Plant Sci.2021, 12: 648426.
  • Food Science&Tech. Res.2022, 28(2):123-132.
  • Inflammation2015, 38(1):445-55
  • Pak J Pharm Sci.2018, 31:311-315
  • Iranian J. Pharm. Res.2021, 20(4):59-70
  • Mol Immunol. 2016, 78:121-132
  • Int J Mol Sci.2023, 24(18):13713.
  • Front Pharmacol.2021, 12:635510.
  • Mol Cancer Ther.2024, 1535-7163.
  • J Med Food.2021, 24(2):151-160.
  • ...
    • 生物活性
    Description: Kaempferol-3-beta-O-glucuronide has antioxidant activity. Flavonoid glucuronides can be deconjugated by microsomal β-glucuronidase from various human cells.
    In vitro:
    Z Naturforsch C. 2007 Sep-Oct;62(9-10):656-60.
    Evaluation of cytotoxic compounds from calligonum comosum L. growing in Egypt.[Pubmed: 18069236]

    METHODS AND RESULTS:
    Calligonum comosum (Polygonaceae), an Egyptian desert plant, was extracted and fractionated using petroleum ether, methylene chloride, and ethyl acetate. The total methanolic extract and other fractions were tested for their anticancer activity using Ehrlich ascites, brine shrimp and antioxidant assays. Ethyl acetate fraction proved to be the most active in all assays. Eight compounds were isolated, purified, and identified from this fraction as (+)-catechin (1), dehydrodicatechin A (2), kaempferol-3-O-rhamnopyranoside (3), quercitrin (quercetin-3-O-rhamnopyranoside) (4), beta-sitosterol-3-O-glucoside (5), isoquercitrin (quercetin-3-O-glucopyranoside) (6), kaempferol-3-O-glucuronide (Kaempferol-3-beta-O-glucuronide,7), and mequilianin (quercetin-3-O-glucuronide) (8).
    CONCLUSIONS:
    All isolated compounds were tested for their cytotoxicity and antioxidant activity. Compound 2 showed the best cytotoxic and antioxidant activity.
    In vivo:
    Int Immunopharmacol . 2018 Apr;57:62-71.
    Kaempferol-3-o-β-d-glucuronate exhibit potential anti-inflammatory effect in LPS stimulated RAW 264.7 cells and mice model[Pubmed: 29475097]
    Abstract Kaempferol-3-O-β-d-glucuronide (K3G) having various pharmacological effects was explored for its anti-inflammatory effect in LPS induced RAW 264.7 cells and mice model. K3G significantly inhibited various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. It upregulated the secretion of anti-inflammatory cytokine IL-10. K3G is found to reduce inflammation when studied for parameters like phagocytic index, carrageenan induced paw edema in mice and organ weight. It reduced inflammation in a dose dependent manner both in-vitro and in-vivo. Further molecular insights into the study reveal that K3G blocks the phosphorylation of NF-kB which is key regulator of inflammation, thereby exhibiting anti-inflammatory potential. Hence, this study permits further investigation to develop K3G as anti-inflammatory drug. Keywords: Anti-inflammatory; Histopathology; Pathway elucidation; Proinflammatory.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1628 mL 10.8141 mL 21.6282 mL 43.2563 mL 54.0704 mL
    5 mM 0.4326 mL 2.1628 mL 4.3256 mL 8.6513 mL 10.8141 mL
    10 mM 0.2163 mL 1.0814 mL 2.1628 mL 4.3256 mL 5.407 mL
    50 mM 0.0433 mL 0.2163 mL 0.4326 mL 0.8651 mL 1.0814 mL
    100 mM 0.0216 mL 0.1081 mL 0.2163 mL 0.4326 mL 0.5407 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    堪非醇3-O-(6''-O-乙酰基)葡萄糖甙; 6''-O-Acetylastragalin CFN99281 118169-27-0 C23H22O12 = 490.4 5mg QQ客服：2056216494
    2''-乙酰基黄芪苷; 2''-Acetylastragalin CFN97940 1206734-95-3 C23H22O12 = 490.4 5mg QQ客服：2056216494
    山奈酚 3-O-(6''-没食子酰基)-beta-D-吡喃葡萄糖苷; Kaempferol 3-O-(6''-galloyl)-beta-D-glucopyranoside (Astragalin 6''-O-gallate) CFN92383 56317-05-6 C28H24O15 = 600.5 5mg QQ客服：2159513211
    山奈酚 3-(2''-没食子酰基葡萄糖苷); Kaempferol 3-(2''-galloylglucoside) CFN95692 76343-90-3 C28H24O15 = 600.5 5mg QQ客服：1457312923
    银椴苷； 椴树苷; Tiliroside CFN98026 20316-62-5 C30H26O13 = 594.5 20mg QQ客服：2159513211
    顺式银椴苷; cis-Tiliroside CFN92265 163956-16-9 C30H26O13 = 594.5 5mg QQ客服：2159513211
    山奈酚-3-O-(2',6'-二-O-反式-对-香豆酰基)-beta-D-吡喃葡萄糖苷; Kaempferol-3-O-(2',6'-di-O-trans-p-coumaroyl)-beta-D-glucopyranoside CFN92386 121651-61-4 C39H32O15 = 740.7 5mg QQ客服：215959384
    3'',4''-Di-O-acetyl-2'',6''-di-O-p-coumaroylastragalin; 3'',4''-Di-O-acetyl-2'',6''-di-O-p-coumaroylastragalin CFN96315 137018-33-8 C43H36O17 = 824.8 5mg QQ客服：2056216494
    3'',4''-二乙酰基-2'',6''-对-香豆酰氧基二紫芸英苷; 3'',4''-Di-O-acetyl-2'',6''-di-O-p-coumaroylastragalin CFN96530 349545-02-4 C43H36O17 = 824.74 5mg QQ客服：215959384
    5''-O-乙酰基胡桃苷; 5''-O-Acetyljuglanin CFN96533 885697-82-5 C22H20O11 = 460.39 5mg QQ客服：215959384

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