异肥皂草苷

Isosaponarin

	产品编号	CFN90133
	CAS编号	19416-87-6
	分子式 = 分子量	C₂₇H₃₀O₁₅ = 594.52
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The seeds of Vaccaria segetalis
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
异肥皂草苷	CFN90133	19416-87-6	1mg	QQ客服：3257982914
异肥皂草苷	CFN90133	19416-87-6	5mg	QQ客服：3257982914
异肥皂草苷	CFN90133	19416-87-6	10mg	QQ客服：3257982914
异肥皂草苷	CFN90133	19416-87-6	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universit?t Basel (Switzerland)

Medical University of South Carolina (USA)

University of Toronto (Canada)

National Research Council of Canada (Canada)

University of British Columbia (Canada)

University of Canterbury (New Zealand)

Shanghai Institute of Biochemistry and Cell Biology (China)

Kyoto University (Japan)

Korea Food Research Institute(KFRI) (Korea)

Nanjing University of Chinese Medicine (China)

Instituto Politécnico de Bragan?a (Portugal)

Max Rubner-Institut (MRI) (Germany)

University of Bordeaux (France)

University of Sao Paulo (Brazil)

More...

Description:

Isosaponarin increases collagen synthesis in human fibroblasts, causes by up-regulated TbetaR-II and P4H production.

Targets:

TGF-β/Smad

In vitro:

J Nat Med. 2010 Jul;64(3):305-12.

The effect of isosaponarin isolated from wasabi leaf on collagen synthesis in human fibroblasts and its underlying mechanism.[Pubmed: 20349148 ]

Wasabi has been used as an important spice in Japanese foods. The wasabi leaves were used as a cosmetic material, but its biological activities have not yet been examined.
METHODS AND RESULTS:
We investigated the effect of Isosaponarin derived from wasabi leaf on collagen synthesis in human fibroblasts. The production of type I collagen in human fibroblasts was increased with treatment of wasabi leaf extract. Isosaponarin isolated from wasabi leaves belonged to the group of flavone glycoside, and was the key compound in collagen synthesis from the wasabi leaf ingredients. Isosaponarin increased the type I collagen production at the mRNA gene level. The treatment of Isosaponarin did not influence the production of transforming growth factor-beta (TGF-beta) protein, but increased the production of TGF-beta type II receptor (TbetaR-II) protein and TbetaR-II mRNA. Prolyl 4-hydroxylase (P4H) protein and P4H mRNA were increased by treatment with Isosaponarin. Heat shock protein 47 (HSP47) was not increased by treatment with Isosaponarin.
CONCLUSIONS:
These results suggested that Isosaponarin increased collagen synthesis in human fibroblasts, caused by up-regulated TbetaR-II and P4H production.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
芹菜素-6-C-beta-葡萄糖-8-C-[alpha-L-鼠李糖-(1->2)]-beta-葡萄糖苷; Apigenin-6-C-beta-D-glucopyranosyl-8-C-[alpha-L-rhamnopyranosyl-(1->2)]-beta-glucopyranoside	CFN95540	1646598-06-2	C₃₃H₄₀O₁₉ = 740.7	5mg	QQ客服：2159513211
Apigenin-8-C-beta-D-glucopyranosyl-6-C-[alpha-L-rhamnopyranosyl-(1->2)]-beta-glucopyranoside; Apigenin-8-C-beta-D-glucopyranosyl-6-C-[alpha-L-rhamnopyranosyl-(1->2)]-beta-glucopyranoside	CFN95548	N/A	C₃₃H₄₀O₁₉ = 740.7	5mg	QQ客服：2056216494
异牡荆黄素 2''-O-阿拉伯糖苷; Isovitexin 2''-O-arabinoside	CFN90943	53382-71-1	C₂₆H₂₈O₁₄ = 564.49	10mg	QQ客服：1457312923
异牡荆素-2''-O-鼠李糖苷; Isovitexin-2''-O-rhamnoside (2''-O-alpha-L-Rhamnopyranosyl-isovitexin)	CFN95314	72036-50-1	C₂₇H₃₀O₁₄ = 578.5	5mg	QQ客服：1457312923
Isomargaritene; Isomargaritene	CFN95304	64271-11-0	C₂₈H₃₂O₁₄ = 592.6	10mg	QQ客服：1413575084
6''-O-乙酰基异牡荆黄素; 6''-O-acetylisovitexin	CFN99341	1223097-20-8	C₂₃H₂₂O₁₁ = 474.4	5mg	QQ客服：1413575084
Meloside A; Meloside A	CFN90132	60767-80-8	C₂₇H₃₀O₁₅ = 594.52	5mg	QQ客服：1457312923
异肥皂草苷; Isosaponarin	CFN90133	19416-87-6	C₂₇H₃₀O₁₅ = 594.52	10mg	QQ客服：215959384
王不留行黄酮苷; Vaccarin	CFN90131	53452-16-7	C₃₂H₃₈O₁₉ = 726.64	20mg	QQ客服：3257982914
异肥皂草苷 2''-O-葡萄糖苷; Isosaponarin 2''-O-glucoside (Isovitexin-2''-4'-di-O-beta-D-glucoside)	CFN95296	63316-27-8	C₃₃H₄₀O₂₀ = 756.7	10mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.682 mL	8.4101 mL	16.8203 mL	33.6406 mL	42.0507 mL
5 mM	0.3364 mL	1.682 mL	3.3641 mL	6.7281 mL	8.4101 mL
10 mM	0.1682 mL	0.841 mL	1.682 mL	3.3641 mL	4.2051 mL
50 mM	0.0336 mL	0.1682 mL	0.3364 mL	0.6728 mL	0.841 mL
100 mM	0.0168 mL	0.0841 mL	0.1682 mL	0.3364 mL	0.4205 mL