7,2'-羟基-3',4'-二甲氧基异黄烷

Isomucronulatol

	产品编号	CFN90839
	CAS编号	52250-35-8
	分子式 = 分子量	C₁₇H₁₈O₅ = 302.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The roots of Astragalus membranaceus
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
7,2'-羟基-3',4'-二甲氧基异黄烷	CFN90839	52250-35-8	1mg	QQ客服：3257982914
7,2'-羟基-3',4'-二甲氧基异黄烷	CFN90839	52250-35-8	5mg	QQ客服：3257982914
7,2'-羟基-3',4'-二甲氧基异黄烷	CFN90839	52250-35-8	10mg	QQ客服：3257982914
7,2'-羟基-3',4'-二甲氧基异黄烷	CFN90839	52250-35-8	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Stanford University (USA)

University of Bonn (Germany)

Centrum Menselijke Erfelijkheid (Belgium)

University of Toronto (Canada)

Ain Shams University (Egypt)

Celltrion Chemical Research Institute (Korea)

Universiti Kebangsaan Malaysia (Malaysia)

Siksha O Anusandhan University (India)

University of Brasilia (Brazil)

National Cancer Institute (USA)

Sanford Burnham Prebys Medical Discovery Institute (USA)

The Vancouver Prostate Centre (VPC) (Canada)

University of Amsterdam (Netherlands)

University of Limpopo (South Africa)

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Description:

Isoliquiritigenin and liquiritigenin exhibit significant inhibitory effects on LPS-induced IL-6 and IL-12 p40 production, with IC 50 values ranging from 2.7 to 6.102uM, isoliquiritigenin also shows a moderate inhibitory effect on LPS-stimulated production of TNF-α with an IC 50 value of 20.102 uM, they have potential anti-inflammatory effects. Isomucronulatol exhibits noticeable ABTS+ scavenging activity, it exhibits moderate inhibition against butyrylcholinesterase.

Targets:

TNF-α | IL Receptor | AChR

In vitro:

Arch. Pharm. Res. 2014, 37(2):186-92.

Flavonoids from Astragalus membranaceus and their inhibitory effects on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells.[Pubmed: 23771500 ]

Radix Astragali (Astragalus membranaceus) is an important traditional Chinese medicine that is widely used as a tonic to enhance the body's natural defense mechanisms.
METHODS AND RESULTS:
In this phytochemical study, 12 flavonoids, isoliquiritigenin (1), liquiritigenin (2), calycosin (3), calycosin 7-O-β-D-glucoside (4), formononetin (5), formononetin 7-O-β-D-glucoside (6), daidzein (7), daidzein 7-O-β-D-glucoside (8), methylnissolin (9), methylnissolin 3-O-β-D-glucoside (10), isomucronulatol (11), and isomucronulatol 7-O-β-D-glucoside (12), were isolated from the roots of A. membranaceus. Their structures were elucidated by comparing spectroscopic data with reported values. The effects of the isolated compounds on lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells were investigated.
CONCLUSIONS:
Compounds 1 and 2 exhibited significant inhibitory effects on LPS-induced IL-6 and IL-12 p40 production, with IC50 values ranging from 2.7 to 6.1 μM. Compound 1 also showed a moderate inhibitory effect on LPS-stimulated production of TNF-α with an IC50 value of 20.1 μM. Further studies of the potential anti-inflammatory effects and benefits of flavonoids from A. membranaceus are warranted.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
去甲基驴食草酚; Demethylvestitol	CFN96183	65332-45-8	C₁₅H₁₄O₄ = 258.3	5mg	QQ客服：1413575084
驴食草酚; Vestitol	CFN98483	35878-41-2	C₁₆H₁₆O₄ = 272.3	5mg	QQ客服：2159513211
Isosativan; Isosativan	CFN97016	60102-29-6	C₁₇H₁₈O₄ = 286.3	5mg	QQ客服：215959384
(-)-Sativan; (-)-Sativan	CFN89475	41743-86-6	C₁₇H₁₈O₄ = 286.32	5mg	QQ客服：2056216494
Sativan; Sativan	CFN96501	71831-00-0	C₁₇H₁₈O₄ = 286.32	5mg	QQ客服：1413575084
(R)-Mucronulatol; (R)-Mucronulatol	CFN95492	57128-11-7	C₁₇H₁₈O₅ = 302.3	10mg	QQ客服：1413575084
Mucronulatol; Mucronulatol	CFN95386	20878-98-2	C₁₇H₁₈O₅ = 302.3	5mg	QQ客服：1457312923
3',8-二羟基驴食草酚; 3',8-Dihydroxyvestitol	CFN95384	122587-87-5	C₁₆H₁₆O₆ = 304.3	5mg	QQ客服：1413575084
光甘草定; Glabridin	CFN99731	59870-68-7	C₂₀H₂₀O₄ = 324.37	20mg	QQ客服：2056216494
Neorauflavane; Neorauflavane	CFN97919	53734-74-0	C₂₁H₂₂O₅ = 354.4	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.308 mL	16.5399 mL	33.0797 mL	66.1594 mL	82.6993 mL
5 mM	0.6616 mL	3.308 mL	6.6159 mL	13.2319 mL	16.5399 mL
10 mM	0.3308 mL	1.654 mL	3.308 mL	6.6159 mL	8.2699 mL
50 mM	0.0662 mL	0.3308 mL	0.6616 mL	1.3232 mL	1.654 mL
100 mM	0.0331 mL	0.1654 mL	0.3308 mL	0.6616 mL	0.827 mL