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  • 异帽叶碱

    Isomitraphylline

    异帽叶碱
    产品编号 CFN89526
    CAS编号 4963-01-3
    分子式 = 分子量 C21H24N2O4 = 368.42
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The leaves of Mitragyna speciosa.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异帽叶碱 CFN89526 4963-01-3 1mg QQ客服:1457312923
    异帽叶碱 CFN89526 4963-01-3 5mg QQ客服:1457312923
    异帽叶碱 CFN89526 4963-01-3 10mg QQ客服:1457312923
    异帽叶碱 CFN89526 4963-01-3 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Technical University of Denmark (Denmark)
  • University of Padjajaran (Indonesia)
  • Celltrion Chemical Research Institute (Korea)
  • University of Vigo (Spain)
  • Max Rubner-Institut (MRI) (Germany)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Lund University (Sweden)
  • Medical University of South Carolina (USA)
  • Universidad de Antioquia (Colombia)
  • University Medical Center Mainz (Germany)
  • Universiti Sains Malaysia (Malaysia)
  • University of Hertfordshire (United Kingdom)
  • FORTH-IMBB (Greece)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Hum Exp Toxicol.2023, 42:9603271231171642.
  • Front Pharmacol.2019, 10:1025
  • Food Funct.2021, 12(13):5892-5902.
  • Separations2023, 10(11), 567;
  • Food Chemistry: X2023, 101032.
  • Pharmacogn Mag.2015, 11(43):562-6
  • Pharmacol Rep.2020, 72(2):472-480.
  • Microchemical Journal2023. 191:108938
  • J Sci Food Agric.2018, 98(3):1153-1161
  • J Ethnopharmacol.2016, 192:370-381
  • iScience.2023, 26(9):107602.
  • Phytomedicine.2023, 116:154841.
  • Chin Med.2022, 17(1):66.
  • Life Sci.2023, 317:121458.
  • Sustainable Chemistry & Pharmacy2022, 30:100883.
  • Molecules.2019, 24(20):3755
  • Pharmaceuticals.2022, 15(4), 402.
  • J Drug Delivery Science and Tech.2022, 67:102957.
  • Food Res Int.2020, 128:108778
  • Plants (Basel).2020, 9(11):1535.
  • Phytother Res.2020, 34(4):788-795.
  • Pharmaceutics.2021, 13(11):1839.
  • Planta Med.2018, 84(15):1101-1109
  • ...
  • 生物活性
    Description: Isomitraphylline and pteropodine are the most suitable for standardization of medical cat's claw preparations. Isomitraphylline can inhibit proliferation of acute lymphoblastic leukaemia cells.
    Targets: Bcl-2/Bax
    In vitro:
    Biotechnol Lett. 2015 Dec;37(12):2489-96.
    Long-term response on growth, antioxidant enzymes, and secondary metabolites in salicylic acid pre-treated Uncaria tomentosa microplants.[Pubmed: 26272395]
    To obtain micro propagated Uncaria tomentosa plantlets with enhanced secondary metabolites production, long-term responses to salicylic acid (SA) pre-treatments at 1 and 100 μM were evaluated after propagation of the plantlets in a SA-free medium.
    METHODS AND RESULTS:
    SA pre-treatments of single node cuttings OF U. tomentosa produced long-term responses in microplants grown for 75 days in a SA-free medium. Reduction in survival rate, root formation, and stem elongation were observed only with 100 μM SA pre-treatments with respect to the control (0 + DMSO).Both pre-treatments enhanced H2O2 and inhibited superoxide dismutase and catalase activities, while guaiacol peroxidase was increased only with 1 μM SA. Also, both pre-treatments increased total monoterpenoid oxindole alkaloids by ca. 55 % (16.5 mg g(-1) DW), including isopteropodine, speciophylline, mitraphylline, Isomitraphylline, rhynchopylline, and isorhynchopylline; and flavonoids by ca. 21 % (914 μg g(-1) DW), whereas phenolic compounds were increased 80 % (599 μg g(-1) DW) at 1 μM and 8.2 % (359 μg g(-1) DW) at 100 μM SA.
    CONCLUSIONS:
    Pre-treatment with 1 μM SA of U.tomentosa microplants preserved the survival rate and increased oxindole alkaloids, flavonoids, and phenolic compounds in correlation with H2O2 and peroxidase activity enhancements, offering biotechnological advantages over non-treated microplants.
    Pharmacol Rep. 2007 Sep-Oct;59(5):565-72.
    Antiproliferative activity of various Uncaria tomentosa preparations on HL-60 promyelocytic leukemia cells.[Pubmed: 18048957]
    The woody Amazonian vine Uncaria tomentosa (cat's claw) has been recently more and more popular all over the world as an immunomodulatory, antiinflammatory and anti-cancer remedy.
    METHODS AND RESULTS:
    This study investigates anti-proliferative potency of several cat's claw preparations with different quantitative and qualitative alkaloid contents on HL-60 acute promyelocytic human cells by applying trypan blue exclusion and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction assay (MTT).
    CONCLUSIONS:
    By standardization and statistical comparison of the obtained results pteropodine and isomitraphylline are indicated to be most suitable for standardization of medical cat's claw preparations.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7143 mL 13.5715 mL 27.1429 mL 54.2859 mL 67.8573 mL
    5 mM 0.5429 mL 2.7143 mL 5.4286 mL 10.8572 mL 13.5715 mL
    10 mM 0.2714 mL 1.3571 mL 2.7143 mL 5.4286 mL 6.7857 mL
    50 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.0857 mL 1.3571 mL
    100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.5429 mL 0.6786 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异帽叶碱; Isomitraphylline CFN89526 4963-01-3 C21H24N2O4 = 368.42 5mg QQ客服:2159513211
    钩藤碱 A; Uncarine A CFN89492 6899-73-6 C21H24N2O4 = 368.42 5mg QQ客服:3257982914
    11-甲氧基钩藤碱 C; 11-Methoxyuncarine C CFN97056 61665-08-5 C22H26N2O5 = 398.5 5mg QQ客服:2056216494
    长春内日啶; Vineridine CFN98460 3489-06-3 C22H26N2O5 = 398.5 5mg QQ客服:215959384
    Caboxine A; Caboxine A CFN98901 53851-13-1 C22H26N2O5 = 398.5 5mg QQ客服:1457312923
    异卡拉巴宾; Isocarapanaubine CFN99819 17391-09-2 C23H28N2O6 = 428.5 5mg QQ客服:2056216494

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