| In vitro: |
| Tetrahedron, 2007,63(20): 4243–4249. | | Structure and neurotrophic activity of novel sesqui-neolignans from the pericarps of Illicium fargesii[Reference: WebLink] |
METHODS AND RESULTS:
The structures of three new sesqui-neolignans, fargenin (1) and fargenones A and B (2 and 3), together with two previously known sesqui-neolignans, macranthol (4) and isodunnianol (5), isolated from the methanol extract of the pericarps of Illicium fargesii were elucidated on the basis of spectroscopic data. Compounds 1–3 are the second three examples of the sesqui-neolignans that contain a variety of non-aromatic rings, and their plausible biosynthetic routes from chavicol are proposed.
CONCLUSIONS:
Among the isolated sesqui-neolignans, isodunnianol has been found to exhibit neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 μM in the primary cultured rat cortical neurons. | | Planta Med.,2014, 80(10):807-807. | | Compounds from the bark of Illicium tsaii and their anti-inflammatory activity[Reference: WebLink] | Illicium tsaii is a Chinese native species growing in northwest China. The bark of I. tsaii, has been applied for the treatment of rheumatoid arthritis. Phytochemical investigation on this species resulted in the isolation and characterization of 28 compounds from the stem bark of I. tsaii.
METHODS AND RESULTS:
Structure determination was accomplished by means of spectroscopic data interpretation. The biological activity of the isolated compounds was evaluated toward multiple targets related to inflammation such as NAG-1, NF-κB, iNOS and ROS. Sesquilignans showed significant activity, among which dunnianol, macranthol and Isodunnianol increased NAG-1 activity 1.5 – 3.0 fold and decreased cellular oxidative stress by 40 – 65%.
CONCLUSIONS:
These three compounds showed substantial activity against iNOS, while only macranthol showed activity against NF-κB. This is the first study on the constituents of I. tsaii and evaluation of their biological activity. |
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