异绿原酸C

Isochlorogenic acid C

	产品编号	CFN99120
	CAS编号	32451-88-0
	分子式 = 分子量	C₂₅H₂₄O₁₂ = 516.45
	产品纯度	>=98%
	物理属性	White powder
	化合物类型	Phenylpropanoids
	植物来源	The flowerbud of Lonicera japonica Thunb.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
异绿原酸C	CFN99120	32451-88-0	10mg	QQ客服：215959384
异绿原酸C	CFN99120	32451-88-0	20mg	QQ客服：215959384
异绿原酸C	CFN99120	32451-88-0	50mg	QQ客服：215959384
异绿原酸C	CFN99120	32451-88-0	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Texas A&M University (USA)

Technical University of Denmark (Denmark)

Research Unit Molecular Epigenetics (MEG) (Germany)

Macau University of Science and Technology (China)

Universidade da Beira Interior (Germany)

University of Zurich (Switzerland)

The Ohio State University (USA)

Uniwersytet Medyczny w ?odzi (Poland)

Stanford University (USA)

Periyar University (India)

University of Brasilia (Brazil)

Charles Sturt University (Denmark)

University of Wisconsin-Madison (USA)

Universidade Federal de Santa Catarina (Brazil)

More...

Description:

Isochlorogenic acid C possesses potent hepatoprotective and anti-HBV effects, its anti-apoptotic and anti-injury effects could be achieved by its anti-oxidative properties and interfering the caspase-3 and TGF-β1 expressions.

Targets:

HBV | HO-1 | TGF-β/Smad | Caspase

In vitro:

J. Med. Plants Res., 2012,6(16):3199-206.

Evaluation of anti-apoptotic, anti-injury and antihepatitis B virus effects of isochlorogenic acid C in vitro[Reference: WebLink]

To study anti-hepatitis effect of isochlorogenic acid C from Laggera alata, anti-apoptotic and anti-injury properties of test compound were evaluated using the D-galactosamine (D-GalN)-induced apoptosis/injury model in human hepatocyte line HL-7702 cells. Hepatocyte apoptotic changes were demonstrated by DNA ladder analysis and caspase-3 activation. Hepatocyte injury was assessed by cell viability. Meanwhile, anti-hepatitis B virus (anti-HBV) effect of test compound was evaluated by the HBsAg, HBeAg, HBV DNA, HBV covalently closed circular DNA (HBV cccDNA) and heme oxygenase-1 (HO-1) expressions in HBV-transfected HepG2.2.15 cells. The results showed that test compound at concentrations of 10 to 100 μg/ml significantly reduced the caspase-3 and transformed growth factor β1 (TGFβ1) levels of the D-GalN-challenged hepatocytes. Also, test compound improved markedly cell viability of the D-GalN-injured hepatocytes and produced a maximum protection rate of 47.28% at a concentration of 100 g/ml. Furthermore, test compound significantly inhibited productions of HBsAg and HBeAg. Its maximum inhibitory rates on the HBsAg and HBeAg expressions were 86.93 and 59.79%, respectively. In addition, test compound significantly induced the HO-1 expression of HepG2.2.15 cells. This study verifies that isochlorogenic acid C possesses potent hepatoprotective and anti-HBV effects. The anti-apoptotic and anti-injury effects of test compound could be achieved by its anti-oxidative properties and interfering the caspase-3 and TGF-β1 expressions. The anti-HBV target of test compound may mainly be at the downstream links of HBV replication process and is probably associated with blocking translation step. Furthermore, HO-1 induction may contribute to anti-hepatitis B effect of test compound.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
异绿原酸C 4'-O-葡萄糖; Isochlorogenic acid C 4'-O-glucoside	CFN95405	N/A	C₃₁H₃₄O₁₇ = 678.6	5mg	QQ客服：2056216494
4,5-O-二咖啡酰基奎宁酸甲酯; 4,5-Di-O-caffeoylquinic acid methyl ester	CFN90858	188742-80-5	C₂₆H₂₆O₁₂ = 530.5	5mg	QQ客服：1457312923
3,4,5-三咖啡酰奎宁酸; 3,4,5-Tricaffeoylquinic acid	CFN90238	86632-03-3	C₃₄H₃₀O₁₅ = 678.59	5mg	QQ客服：2056216494
单咖啡酰洒石酸; Caftaric acid	CFN00384	67879-58-7	C₁₃H₁₂O₉ = 312.2	20mg	QQ客服：2056216494
菊苣酸; Chicoric acid	CFN99725	6537-80-0	C₂₂H₁₈O₁₂ = 474.37	20mg	QQ客服：3257982914
1,4-二咖啡酰奎宁酸; 1,4-Dicaffeoylquinic acid	CFN99122	1182-34-9	C₂₅H₂₄O₁₂ = 516.46	5mg	QQ客服：3257982914
1,5-二咖啡酰奎宁酸; 1,5-Dicaffeoylquinic acid	CFN90937	19870-46-3	C₂₅H₂₄O₁₂ = 516.5	20mg	QQ客服：2056216494
4-O-咖啡酰-3-O-丁香酰奎宁酸; 4-O-Caffeoyl-3-O-syringoylquinic acid	CFN95430	1207645-17-7	C₂₅H₂₆O₁₃ = 534.5	5mg	QQ客服：215959384
异绿原酸B; Isochlorogenic acid B	CFN99119	14534-61-3	C₂₅H₂₄O₁₂ = 516.45	20mg	QQ客服：1457312923
3,4-二咖啡酰奎宁酸乙酯; Ethyl 3,4-dicaffeoylquinate	CFN91970	143051-73-4	C₂₇H₂₈O₁₂ = 544.50	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9363 mL	9.6815 mL	19.363 mL	38.7259 mL	48.4074 mL
5 mM	0.3873 mL	1.9363 mL	3.8726 mL	7.7452 mL	9.6815 mL
10 mM	0.1936 mL	0.9681 mL	1.9363 mL	3.8726 mL	4.8407 mL
50 mM	0.0387 mL	0.1936 mL	0.3873 mL	0.7745 mL	0.9681 mL
100 mM	0.0194 mL	0.0968 mL	0.1936 mL	0.3873 mL	0.4841 mL