4-甲氧基-3-羟基苯乙酮

Isoacetovanillone

	产品编号	CFN96859
	CAS编号	6100-74-9
	分子式 = 分子量	C₉H₁₀O₃ = 166.17
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The herbs of Pycnocycla spinosa Boiss.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
4-甲氧基-3-羟基苯乙酮	CFN96859	6100-74-9	10mg	QQ客服：215959384
4-甲氧基-3-羟基苯乙酮	CFN96859	6100-74-9	20mg	QQ客服：215959384
4-甲氧基-3-羟基苯乙酮	CFN96859	6100-74-9	50mg	QQ客服：215959384
4-甲氧基-3-羟基苯乙酮	CFN96859	6100-74-9	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Complutense University of Madrid (Spain)

Griffith University (Australia)

Srinakharinwirot University (Thailand)

Lodz University of Technology (Poland)

University of Helsinki (Finland)

Charles University in Prague (Czech Republic)

University of Sao Paulo (Brazil)

Kyoto University (Japan)

Sanford Burnham Medical Research Institute (USA)

Centrum Menselijke Erfelijkheid (Belgium)

Kyung Hee University (Korea)

The Australian National University (Australia)

Kazusa DNA Research Institute (Japan)

Universidade de Franca (Brazil)

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Description:

Isoacetovanillone shows anti-inflammatory potential.

Targets:

Immunology & Inflammation related

In vivo:

Res Pharm Sci. 2015 Jul-Aug;10(4):345-55.

Anti-inflammatory effect of Pycnocycla spinosa extract and its component isoacetovanillone on acetic acid induced colitis in rats.[Pubmed: 26600861 ]

Colitis is an inflammatory disease of the intestine with unknown etiology involving multiple immune, genetic and environmental factors. We were interested to examine the effect of total extract from Pycnocycla spinosa Boiss. on the treatment of experimental colitis. Mediators involved in colonic inflammation are prostaglandins, interleukins, leukotriene as well as an increase in myeloperoxidase (MPO) activity.
METHODS AND RESULTS:
Therefore, MPO activity was also determined in this research. P. spinosa hydroalcoholic extract (5, 10 and 20 mg/kg) or Isoacetovanillone (2, 5 and 10 mg/kg) were administered orally, started 2 h before induction of colitis by intrarectal administration of acetic acid (3%) in rats. Prednisolone (4 m/kg) was used as the standard drug for comparison. Biochemical evaluation of inflamed colon was done using assay of MPO activity. After 5 days treatments, mucosal ulceration was evaluated. Intrarectal instillation of acetic acid caused significant inflammatory reactions as indicated by macroscopic and microscopic changes. The activity of MPO increased in vehicle treated groups while recovered to normal level by pretreatment of animals with P. spinosa extract, Isoacetovanillone and prednisolone. P. spinosa and Isoacetovanillone-treated groups showed significantly lower score values of macroscopic and microscopic characters when compared with the vehicle treated negative control group. The beneficial effect of P. spinosa was comparable with that of prednisolone.
CONCLUSIONS:
This research has shown the anti-inflammatory potential of P. spinosa extract and Isoacetovanillone in experimentally induced colitis.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.0179 mL	30.0897 mL	60.1793 mL	120.3587 mL	150.4483 mL
5 mM	1.2036 mL	6.0179 mL	12.0359 mL	24.0717 mL	30.0897 mL
10 mM	0.6018 mL	3.009 mL	6.0179 mL	12.0359 mL	15.0448 mL
50 mM	0.1204 mL	0.6018 mL	1.2036 mL	2.4072 mL	3.009 mL
100 mM	0.0602 mL	0.3009 mL	0.6018 mL	1.2036 mL	1.5045 mL

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