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  • 4-甲氧基-3-羟基苯乙酮

    • 4-甲氧基-3-羟基苯乙酮

    Isoacetovanillone

    4-甲氧基-3-羟基苯乙酮
    		产品编号 CFN96859
    CAS编号 6100-74-9
    分子式 = 分子量 C9H10O3 = 166.17
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The herbs of Pycnocycla spinosa Boiss.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4-甲氧基-3-羟基苯乙酮 CFN96859 6100-74-9 10mg QQ客服：2159513211
    4-甲氧基-3-羟基苯乙酮 CFN96859 6100-74-9 20mg QQ客服：2159513211
    4-甲氧基-3-羟基苯乙酮 CFN96859 6100-74-9 50mg QQ客服：2159513211
    4-甲氧基-3-羟基苯乙酮 CFN96859 6100-74-9 100mg QQ客服：2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Macau University of Science and Technology (China)
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  • Universite de Lille1 (France)
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  • University of Illinois (USA)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Chem.2022, 378:131975.
  • Eur J Pharmacol.2018, 832:96-103
  • FEBS Lett.2015, 589(1):182-7
  • Molecules.2019, 24(4):E709
  • Biomed Pharmacother.2024, 175:116770.
  • Food Chem.2023, 427:136647.
  • Horticulture Research2023, uhad164.
  • J Biomol Struct Dyn.2022, 1-21.
  • Int. Conference on Med. Sci. and Bio.2017, 17973
  • Appl. Sci. 2021, 11(22), 10552
  • J Cell Mol Med.2023, jcmm.18071.
  • Semyung University2017, 149407
  • Nanjing University of Chinese Medicine2022, 345930.
  • J Nat Med.2020, 74(1):65-75
  • Acta horticulturae2017, 1158:257-268
  • J Biochem Mol Toxicol.2020, 34(7):e22489.
  • Institute of Food Science & Technology2021, 18 December.
  • Acta Physiologiae Plantarum2016, 38:7
  • The Catharanthus Genome2022,35-83.
  • Molecules.2021, 26(9):2802.
  • Molecules.2019, 24(22):E4022
  • J Med Food.2021, 24(3):209-217.
  • Revista Brasileira de Farmacognosia2021, 31:794-804.
  • ...
    • 生物活性
    Description: Isoacetovanillone shows anti-inflammatory potential.
    Targets: Immunology & Inflammation related
    In vivo:
    Res Pharm Sci. 2015 Jul-Aug;10(4):345-55.
    Anti-inflammatory effect of Pycnocycla spinosa extract and its component isoacetovanillone on acetic acid induced colitis in rats.[Pubmed: 26600861 ]
    Colitis is an inflammatory disease of the intestine with unknown etiology involving multiple immune, genetic and environmental factors. We were interested to examine the effect of total extract from Pycnocycla spinosa Boiss. on the treatment of experimental colitis. Mediators involved in colonic inflammation are prostaglandins, interleukins, leukotriene as well as an increase in myeloperoxidase (MPO) activity.
    METHODS AND RESULTS:
    Therefore, MPO activity was also determined in this research. P. spinosa hydroalcoholic extract (5, 10 and 20 mg/kg) or Isoacetovanillone (2, 5 and 10 mg/kg) were administered orally, started 2 h before induction of colitis by intrarectal administration of acetic acid (3%) in rats. Prednisolone (4 m/kg) was used as the standard drug for comparison. Biochemical evaluation of inflamed colon was done using assay of MPO activity. After 5 days treatments, mucosal ulceration was evaluated. Intrarectal instillation of acetic acid caused significant inflammatory reactions as indicated by macroscopic and microscopic changes. The activity of MPO increased in vehicle treated groups while recovered to normal level by pretreatment of animals with P. spinosa extract, Isoacetovanillone and prednisolone. P. spinosa and Isoacetovanillone-treated groups showed significantly lower score values of macroscopic and microscopic characters when compared with the vehicle treated negative control group. The beneficial effect of P. spinosa was comparable with that of prednisolone.
    CONCLUSIONS:
    This research has shown the anti-inflammatory potential of P. spinosa extract and Isoacetovanillone in experimentally induced colitis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.0179 mL 30.0897 mL 60.1793 mL 120.3587 mL 150.4483 mL
    5 mM 1.2036 mL 6.0179 mL 12.0359 mL 24.0717 mL 30.0897 mL
    10 mM 0.6018 mL 3.009 mL 6.0179 mL 12.0359 mL 15.0448 mL
    50 mM 0.1204 mL 0.6018 mL 1.2036 mL 2.4072 mL 3.009 mL
    100 mM 0.0602 mL 0.3009 mL 0.6018 mL 1.2036 mL 1.5045 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,7-二羟基 3,3',4',5',6,8-六甲氧基黄酮; 5,7-Dihydroxy 3,3',4',5',6,8-hexamethoxyflavone CFN70469 96887-18-2 C21H22O10 = 434.4 5mg QQ客服：2159513211
    芦荟苦素; Aloesin CFN91659 30861-27-9 C19H22O9 = 394.37 5mg QQ客服：2159513211
    异烟碱; Isonicoteine CFN00440 581-50-0 C10H8N2 = 156.19 5mg QQ客服：3257982914
    Toxyloxanthone D; Toxyloxanthone D CFN92090 50906-63-3 C23H24O6 = 396.4 5mg QQ客服：2159513211

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