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  • 次野鸢尾黄素

    Irisflorentin

    次野鸢尾黄素
    产品编号 CFN99788
    CAS编号 41743-73-1
    分子式 = 分子量 C20H18O8 = 386.35
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The rhizomes of Belamcanda chinensis (L.) DC.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    次野鸢尾黄素 CFN99788 41743-73-1 10mg QQ客服:215959384
    次野鸢尾黄素 CFN99788 41743-73-1 20mg QQ客服:215959384
    次野鸢尾黄素 CFN99788 41743-73-1 50mg QQ客服:215959384
    次野鸢尾黄素 CFN99788 41743-73-1 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universitas Airlangga (Indonesia)
  • Imperial College London (United Kingdom)
  • Washington State University (USA)
  • Universidad Veracuzana (Mexico)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Max-Planck-Insitut (Germany)
  • Semmelweis Unicersity (Hungary)
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  • Michigan State University (USA)
  • Shanghai University of TCM (China)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Ateneo de Manila University (Philippines)
  • Sant Gadge Baba Amravati University (India)
  • Universiti Malaysia Pahang (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2019, 20(9):E2244
  • Food Research International2023, 113792.
  • Int J Mol Sci.2022, 23(21):12816.
  • Plos One.2020, 10.1371
  • J Agric Food Chem.2019, 67(27):7748-7754
  • Regul Toxicol Pharmacol.2023, 142:105433.
  • J Appl Biol Chem2023, 66:455−461
  • Inflammation.2015, 38(4):1502-16
  • Phytomedicine.2019, 58:152893
  • Plant Archives2020, 2(1),2929-2934
  • RSC Adv.2018, 32621-32636
  • Univerzita Karlova2022, 173245.
  • Talanta.2022, 249:123645.
  • Oncol Rep.2019, 41(4):2453-2463
  • Planta Med.2019, 85(4):347-355
  • Korean J Dent Mater2020, 47(2):63-70.
  • Planta Med.2018, 84(15):1101-1109
  • Antioxidants (Basel).2021, 10(11): 1802.
  • Antioxidants (Basel).2021, 10(10):1638.
  • Korean J of Food Science&Technology 2017, 49(2):146-150
  • Front. Physiol.2022, 790345.
  • Malaysian Journal of Analytical Sciences2022, 26(2):360-369.
  • Srinagarind Medical Journal2019, 34(1)
  • ...
  • 生物活性
    Description: Irisflorentin has anti-inflammatory activity, it can markedly reduce the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO, it also can significantly inhibit TNF-α, IL-1βand IL-6 at both the transcriptional and translational levels; Irisflorentin has potential to ameliorate Parkinson’s disease in Caenorhabditis elegans models by promoting rpn-3 expression and down-regulating egl-1 expression; Irisflorentin may as an immunotherapeutic adjuvant.
    Targets: NOS | NO | TNF-α | IL Receptor | IkB | p65 | JNK | ERK | AP-1 | p38MAPK | NF-kB | IKK
    In vitro:
    Biomedicine (Taipei). 2015;5(1):4. Epub 2015 Feb 2.
    Irisflorentin improves α-synuclein accumulation and attenuates 6-OHDA-induced dopaminergic neuron degeneration, implication for Parkinson's disease therapy.[Pubmed: 25705584]
    Parkinson's disease (PD) is a degenerative disorder of the central nervous system that is characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta as well as motor impairment. Aggregation of α-synuclein in neuronal cells plays a key role in this disease. At present, therapeutics for PD provides moderate symptomatic benefits, but it is not able to delay the development of the disease. Current efforts toward the treatment of PD are to identify new drugs that slow or arrest the progressive course of PD by interfering with a disease-specific pathogenetic process in PD patients. Irisflorentin derived from the roots of Belamcanda chinensis (L.) DC. is an herb which has been used for the treatment of inflammatory disorders in traditional Chinese medicine.
    METHODS AND RESULTS:
    The purpose of the present study was to assess the potential for Irisflorentin to ameliorate PD in Caenorhabditis elegans models. Our data reveal that Irisflorentin prevents α-synuclein accumulation in the transgenic Caenorhabditis elegans model and also improves dopaminergic neuron degeneration, food-sensing behavior, and life-span in a 6-hydroxydopamine-induced Caenorhabditis elegans model, thus indicating its potential as a anti-parkinsonian drug candidate. Irisflorentin may exert its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-1 expression to block apoptosis pathways.
    CONCLUSIONS:
    These findings encourage further investigation on Irisflorentin as a possible potent agent for PD treatment.
    Cell Transplant. 2015;24(3):573-88.
    Irisflorentin modifies properties of mouse bone marrow-derived dendritic cells and reduces the allergic contact hypersensitivity responses.[Pubmed: 25654487]
    Irisflorentin is an isoflavone component derived from the roots of Belamcanda chinensis (L.) DC. In traditional Chinese medicine, this herb has pharmacological properties to treat inflammatory disorders. Dendritic cells (DCs) are crucial modulators for the development of optimal T-cell immunity and maintenance of tolerance. Aberrant activation of DCs can induce harmful immune responses, and so agents that effectively improve DC properties have great clinical value.
    METHODS AND RESULTS:
    We herein investigated the effects of irisflorentin on lipopolysaccharide (LPS)-stimulated maturation of mouse bone marrow-derived DCs in vitro and in the contact hypersensitivity response (CHSR) in vivo. Our results demonstrated that treatment with up to 40 μM irisflorentin does not cause cellular toxicity. Irisflorentin significantly lessened the proinflammatory cytokine production (tumor necrosis factor-α, interleukin-6, and interleukin-12p70) by LPS-stimulated DCs. Irisflorentin also inhibited the expression of LPS-induced major histocompatibility complex class II and costimulatory molecules (CD40 and CD86) on LPS-stimulated DCs. In addition, irisflorentin diminished LPS-stimulated DC-elicited allogeneic T-cell proliferation. Furthermore, irisflorentin significantly interfered with LPS-induced activation of IκB kinase, c-Jun N-terminal kinase, and p38, as well as the nuclear translocation of NF-κB p65. Subsequently, treatment with irisflorentin obviously weakened 2,4-dinitro-1-fluorobenzene-induced delayed-type hypersensitivity.
    CONCLUSIONS:
    These findings suggest new insights into the role of irisflorentin as an immunotherapeutic adjuvant through its capability to modulate the properties of DCs.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5883 mL 12.9416 mL 25.8833 mL 51.7665 mL 64.7082 mL
    5 mM 0.5177 mL 2.5883 mL 5.1767 mL 10.3533 mL 12.9416 mL
    10 mM 0.2588 mL 1.2942 mL 2.5883 mL 5.1767 mL 6.4708 mL
    50 mM 0.0518 mL 0.2588 mL 0.5177 mL 1.0353 mL 1.2942 mL
    100 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.5177 mL 0.6471 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-Hydroxypseudobaptigenin; 5-Hydroxypseudobaptigenin CFN91501 40624-03-1 C16H10O6 = 298.3 5mg QQ客服:215959384
    刺桐素 H; Erythrinin H CFN96559 1616592-62-1 C17H12O7 = 328.28 5mg QQ客服:2159513211
    次野鸢尾黄素; Irisflorentin CFN99788 41743-73-1 C20H18O8 = 386.35 20mg QQ客服:215959384
    野鸢尾黄素; Irigenin CFN93276 548-76-5 C18H16O8 = 360.31 20mg QQ客服:3257982914
    Isolupalbigenin; Isolupalbigenin CFN96522 162616-70-8 C25H26O5 = 406.48 5mg QQ客服:1457312923
    Isoangustone A; Isoangustone A CFN96505 129280-34-8 C25H26O6 = 422.47 5mg QQ客服:2159513211
    Pierreione B; Pierreione B CFN96543 1292766-21-2 C26H28O7 = 452.50 5mg QQ客服:2159513211
    3',4',7-三羟基异黄酮; 3',4',7-Trihydroxyisoflavone CFN70376 485-63-2 C15H10O5 = 270.2 5mg QQ客服:1457312923
    毛蕊异黄酮; Calycosin CFN99140 20575-57-9 C16H12O5 = 284.26 20mg QQ客服:3257982914
    3'-甲氧基大豆黄素; 3'-Methoxydaidzein CFN96186 21913-98-4 C16H12O5 = 284.3 5mg QQ客服:2056216494

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