| Description: |
3'-O-Methylorobol exhibits moderate antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay, it also exerts potential analgesic properties. 3'-O-Methylorobol can increase osteoblast differentiation. |
| In vitro: |
| Phytother Res. 2009 Jan;23(1):129-31. | | Stimulatory constituents of Eclipta prostrata on mouse osteoblast differentiation.[Pubmed: 18683850] |
METHODS AND RESULTS:
One flavonoid, diosmetin (1), and two isoflavonoids, 3'-hydroxybiochanin A (2) and 3'-O-methylorobol (3), were isolated from the methanol extract of Eclipta prostrata L. by a bioactivity-guided fractionation technique using primary cultures of mouse osteoblasts as an in vitro assay system.
CONCLUSIONS:
All three compounds significantly increased osteoblast differentiation as assessed by the alkaline phosphatase activity. | | J Asian Nat Prod Res. 2010 Feb;12(2):138-43. | | Antioxidant flavonoids from Alhagi maurorum.[Pubmed: 20390757] |
METHODS AND RESULTS:
A new flavonoid, isorhamnetin-3-O-[-alpha-l-rhamnopyranosyl-(1 --> 3)]-beta-D-glucopyranoside (1), along with two known flavonoids 3'-O-methylorobol (2) and quercetin 3-O-beta-d-glucopyranoside (3), was isolated from Alhagi maurorum. Their structures were established with the help of mass spectrometry, 1D and 2D NMR spectroscopy, and in comparison with the literature data.
CONCLUSIONS:
Compounds 1 and 2 exhibited moderate antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay. |
|
| In vivo: |
| Records of Natural Products, 2013, 7(3): 169-76. | | Analgesic and Antioxidant Activities of Algerian Retama raetam (Forssk.) Webb & Berthel Extracts.[Reference: WebLink] |
METHODS AND RESULTS:
Part of this work deals with the isolation and structure elucidation of the main polar secondary metabolites of the aerial parts of Retama raetam (Forssk.) Webb & Berthel, as well as the evaluation of their potential analgesic properties, while the rest deals with the antioxidant activities of the aqueous extracts of roots, stem, fruits and flowers of the plant. It was found that the isoflavones genistein 1, 6-hydroxygenistein 2, 3'-O-methylorobol 3, pratensein 4, biochanin A 8, the flavones 6-hydroxyapigenin 7 and luteolin 5, the flavonol kaempferol 6, as well as the phenolic compound p-coumaric acid 9 reduce significantly the pain at a concentration dose of 1 mg/kg. The most active compounds were 3 and 8 (86.19% and 75.23%, respectively).
CONCLUSIONS:
The obtained aqueous extracts of R. raetam were also evaluated for their antioxidant activities using two different photometric methods; the results revealed that all extracts exerted very low free radical scavenging activity compared to the well-known butylated hydroxytoluene (BHT) and lower hydrogen peroxide blocking activity than positive control gallic acid. |
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