野鸢尾黄素

Irigenin

	产品编号	CFN93276
	CAS编号	548-76-5
	分子式 = 分子量	C₁₈H₁₆O₈ = 360.31
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The rhizomes of Belamcanda chinensis (L.) DC.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
野鸢尾黄素	CFN93276	548-76-5	10mg	QQ客服：215959384
野鸢尾黄素	CFN93276	548-76-5	20mg	QQ客服：215959384
野鸢尾黄素	CFN93276	548-76-5	50mg	QQ客服：215959384
野鸢尾黄素	CFN93276	548-76-5	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Korea Institute of Oriental Medicine (Korea)

National Research Council of Canada (Canada)

Universidade Católica Portuguesa (Portugal)

Universidad Industrial de Santander (Colombia)

University of Ioannina (Greece)

Yale University (USA)

University of Illinois at Chicago (USA)

Warszawski Uniwersytet Medyczny (Poland)

University of Medicine and Pharmacy (Romania)

Anna University (India)

University of British Columbia (Canada)

Kyushu University (Japan)

National Cancer Institute (USA)

Universiti Kebangsaan Malaysia (Malaysia)

More...

Description:

Irigenin, an α-glucosidase inhibitor, which has anti-inflammatory, anti-cancer, and anti-metastatic effects. Irigenin can inhibit the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins and mRNAs without an appreciable cytotoxic effect. Irigenin displays moderate activity as inducers of NAD(P)H:quinone reductase (QR) in cultured mouse Hepa 1c1c7 cells.

Targets:

COX | NOS | NAD(P)H:quinone reductase | α-glucosidase | NO | PGE | p65 | NF-κB

In vivo:

Sci Rep. 2016 Nov 16;6:37151.

Irigenin, a novel lead from Western Himalayan chemiome inhibits Fibronectin-Extra Domain A induced metastasis in Lung cancer cells.[Pubmed: 27849000 ]

Several lines of evidence indicate that Fibronectin Extra Domain A (EDA) promotes metastatic capacity of tumor cells by engaging cell surface α9β1 integrins. This interaction mediated by the C-C loop of EDA activates pro-oncogenic signaling pathways leading to epithelial to mesenchymal transition (EMT) of tumor cells, thus signifying its importance in control of metastatic progression.
METHODS AND RESULTS:
In this context the present study was designed to explore the active compounds from selected ethno-medicinal plants of western Himalayan region for targeting EDA of Fibronectin in lung carcinoma cells. Structure based informatics for drug designing and screening was employed to generate a lead compound(s) feed that were conformationally and energetically viable. Out of 120 compounds selected, Irigenin showed best binding-affinity with C-C loop of EDA. Irigenin specifically targeted α9β1 and α4β1 integrin binding sites on EDA comprising LEU46, PHE47, PRO48, GLU58, LEU59 and GLN60 in its C-C loop as evaluated by energy decomposition per residue of Irigenin-EDA complex. In-vitro cell motility assays complemented with EDA knock-in and knockdown assays distinctively demonstrated that Irigenin prevents metastatic capacity of lung cancer cells by selectively blocking EDA.
CONCLUSIONS:
The results presented thus project Irigenin as a lead compound to overcome Fibronectin EDA induced metastatic progression in lung carcinoma cells.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
3',4',7-三羟基异黄酮; 3',4',7-Trihydroxyisoflavone	CFN70376	485-63-2	C₁₅H₁₀O₅ = 270.2	5mg	QQ客服：1413575084
毛蕊异黄酮; Calycosin	CFN99140	20575-57-9	C₁₆H₁₂O₅ = 284.26	20mg	QQ客服：2056216494
3'-甲氧基大豆黄素; 3'-Methoxydaidzein	CFN96186	21913-98-4	C₁₆H₁₂O₅ = 284.3	5mg	QQ客服：2056216494
3',4',5,7-四羟基异黄酮; Orobol	CFN98737	480-23-9	C₁₅H₁₀O₆ = 286.2	5mg	QQ客服：2056216494
3'-O-甲基香豌豆苷元; 3'-O-Methylorobol	CFN98492	36190-95-1	C₁₆H₁₂O₆ = 300.3	5mg	QQ客服：3257982914
7,3'-二-O-甲基奥洛波尔; 7,3'-Di-O-methylorobol	CFN96518	104668-88-4	C₁₇H₁₄O₆ = 314.30	5mg	QQ客服：2056216494
红车轴草素; Pratensein	CFN90805	2284-31-3	C₁₆H₁₂O₆ = 300.3	5mg	QQ客服：215959384
5-Hydroxypseudobaptigenin; 5-Hydroxypseudobaptigenin	CFN91501	40624-03-1	C₁₆H₁₀O₆ = 298.3	5mg	QQ客服：2159513211
Maximaisoflavone B; Maximaisoflavone B	CFN91412	4737-28-4	C₂₁H₁₈O₅ = 350.4	5mg	QQ客服：1413575084
刺桐素 H; Erythrinin H	CFN96559	1616592-62-1	C₁₇H₁₂O₇ = 328.28	5mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7754 mL	13.8769 mL	27.7539 mL	55.5078 mL	69.3847 mL
5 mM	0.5551 mL	2.7754 mL	5.5508 mL	11.1016 mL	13.8769 mL
10 mM	0.2775 mL	1.3877 mL	2.7754 mL	5.5508 mL	6.9385 mL
50 mM	0.0555 mL	0.2775 mL	0.5551 mL	1.1102 mL	1.3877 mL
100 mM	0.0278 mL	0.1388 mL	0.2775 mL	0.5551 mL	0.6938 mL