野鸢尾黄素
Irigenin
|
|
产品编号 |
CFN93276 |
| CAS编号 |
548-76-5 |
| 分子式 = 分子量 |
C18H16O8 = 360.31 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Flavonoids |
| 植物来源 |
The rhizomes of Belamcanda chinensis (L.) DC. |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 野鸢尾黄素 |
CFN93276 |
548-76-5 |
10mg |
QQ客服：1413575084 |
| 野鸢尾黄素 |
CFN93276 |
548-76-5 |
20mg |
QQ客服：1413575084 |
| 野鸢尾黄素 |
CFN93276 |
548-76-5 |
50mg |
QQ客服：1413575084 |
| 野鸢尾黄素 |
CFN93276 |
548-76-5 |
100mg |
QQ客服：1413575084 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
Indian Institute of Science (India)
Florida International University (USA)
Nanjing University of Chinese Medicine (China)
Universidade Federal de Santa Catarina (Brazil)
Yale University (USA)
Centralised Purchases Unit (CPU), B.I.T.S (India)
Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
Technical University of Denmark (Denmark)
Semmelweis Unicersity (Hungary)
University of Wollongong (Australia)
Massachusetts General Hospital (USA)
Hamdard University (India)
Institute of Chinese Materia Medica (China)
Sanford Burnham Prebys Medical Discovery Institute (USA)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Irigenin, an α-glucosidase inhibitor, which has anti-inflammatory, anti-cancer, and anti-metastatic effects. Irigenin can inhibit the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins and mRNAs without an appreciable cytotoxic effect. Irigenin displays moderate activity as inducers of NAD(P)H:quinone reductase (QR) in cultured mouse Hepa 1c1c7 cells. |
| Targets: |
COX | NOS | NAD(P)H:quinone reductase | α-glucosidase | NO | PGE | p65 | NF-κB |
| In vivo: |
| Sci Rep. 2016 Nov 16;6:37151. | | Irigenin, a novel lead from Western Himalayan chemiome inhibits Fibronectin-Extra Domain A induced metastasis in Lung cancer cells.[Pubmed: 27849000 ] | Several lines of evidence indicate that Fibronectin Extra Domain A (EDA) promotes metastatic capacity of tumor cells by engaging cell surface α9β1 integrins. This interaction mediated by the C-C loop of EDA activates pro-oncogenic signaling pathways leading to epithelial to mesenchymal transition (EMT) of tumor cells, thus signifying its importance in control of metastatic progression.
METHODS AND RESULTS:
In this context the present study was designed to explore the active compounds from selected ethno-medicinal plants of western Himalayan region for targeting EDA of Fibronectin in lung carcinoma cells. Structure based informatics for drug designing and screening was employed to generate a lead compound(s) feed that were conformationally and energetically viable. Out of 120 compounds selected, Irigenin showed best binding-affinity with C-C loop of EDA. Irigenin specifically targeted α9β1 and α4β1 integrin binding sites on EDA comprising LEU46, PHE47, PRO48, GLU58, LEU59 and GLN60 in its C-C loop as evaluated by energy decomposition per residue of Irigenin-EDA complex. In-vitro cell motility assays complemented with EDA knock-in and knockdown assays distinctively demonstrated that Irigenin prevents metastatic capacity of lung cancer cells by selectively blocking EDA.
CONCLUSIONS:
The results presented thus project Irigenin as a lead compound to overcome Fibronectin EDA induced metastatic progression in lung carcinoma cells. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.7754 mL |
13.8769 mL |
27.7539 mL |
55.5078 mL |
69.3847 mL |
| 5 mM |
0.5551 mL |
2.7754 mL |
5.5508 mL |
11.1016 mL |
13.8769 mL |
| 10 mM |
0.2775 mL |
1.3877 mL |
2.7754 mL |
5.5508 mL |
6.9385 mL |
| 50 mM |
0.0555 mL |
0.2775 mL |
0.5551 mL |
1.1102 mL |
1.3877 mL |
| 100 mM |
0.0278 mL |
0.1388 mL |
0.2775 mL |
0.5551 mL |
0.6938 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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