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  • 毛花苷C

    Lanatoside C

    毛花苷C
    产品编号 CFN96196
    CAS编号 17575-22-3
    分子式 = 分子量 C49H76O20 = 985.1
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The herbs of Digitalis lanata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    毛花苷C CFN96196 17575-22-3 10mg QQ客服:1413575084
    毛花苷C CFN96196 17575-22-3 20mg QQ客服:1413575084
    毛花苷C CFN96196 17575-22-3 50mg QQ客服:1413575084
    毛花苷C CFN96196 17575-22-3 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sapienza University of Rome (Italy)
  • Max Rubner-Institut (MRI) (Germany)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • University of Bordeaux (France)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Chulalongkorn University (Thailand)
  • Melbourne University (Australia)
  • Colorado State University (USA)
  • University of Madras (India)
  • Hamdard University (India)
  • University of South Australia (Australia)
  • Calcutta University (India)
  • Universidad de La Salle (Mexico)
  • University of Medicine and Pharmacy (Romania)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Med Ther. 2020, 20(1):94.
  • National Academy Science Letters2023, s40009.
  • Eur J Pharmacol.2018, 832:96-103
  • Universite de Bordeaux2017, 2017BORD0867
  • Sci Rep.2019, 9(1):6429
  • J Nat Med.2017, 71(2):380-388
  • Enzyme Microb Technol.2022, 153:109941.
  • Oxid Med Cell Longev.2022, 2022:5888636.
  • Molecules 2021, 26(4),1092.
  • Biochemistry.2018, 57(40):5886-5896
  • Biomolecules2021, 11(10),1513.
  • Processes2021, 9(1), 153;
  • Industrial Crops and Products2018, 353-362
  • Talanta.2022, 249:123645.
  • University of Limpopo2016, 1777
  • J Drug Target.2016, 24:1-28
  • Mediators Inflamm.2016, 2016:7216912
  • J Pharm Biomed Anal.2019, 172:268-277
  • Appl. Sci.2020, 10(20), 7323.
  • Front Aging Neurosci.2019, 11:230
  • Invest New Drugs.2017, 35(2):166-179
  • Appl. Sci. 2021, 11(1),14.
  • Int J Mol Sci.2022, 23(1):538.
  • ...
  • 生物活性
    Description: Lanatoside C, a cardiac glycoside, possesses the ability to inhibit the interchange of Na and K across cell membrane and is widely used to treat anti-arrhythmias and heart failure. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya and Sindbis virus as well as the human enterovirus 71, suggest that lanatoside C possesses broad spectrum antiviral activity against several groups of positive-sense RNA viruses.
    Targets: Akt | mTOR | PKC | Antifection | Potassium Channel | Sodium Channel
    In vitro:
    Sci Rep. 2017 Apr 7;7:46134.
    Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells.[Pubmed: 28387249 ]
    Recent studies have revealed that cardiac glycosides, such as digitalis and digoxin, have anticancer activity and may serve as lead compounds for the development of cancer treatments. The poor prognosis of hepatocellular carcinoma (HCC) patients reflects the development of resistance to current chemotherapeutic agents, highlighting the need for discovering new small-molecule therapeutics.
    METHODS AND RESULTS:
    Here, we found that lanatoside C, an anti-arrhythmic agent extracted from Digitalis lanata, inhibited the growth of HCC cells and dramatically decreased tumor volume as well as delayed tumor growth without obvious body weight loss. Moreover, lanatoside C triggered mitochondrial membrane potential (MMP) loss, activation of caspases and translocation of apoptosis-inducing factor (AIF) into the nucleus, which suggests that lanatoside C induced apoptosis through both caspase-dependent and -independent pathways. Furthermore, we discovered that lanatoside C activated protein kinase delta (PKCδ) via Thr505 phosphorylation and subsequent membrane translocation.
    CONCLUSIONS:
    Inhibition of PKCδ reversed lanatoside C-induced MMP loss and apoptosis, confirming that lanatoside C caused apoptosis through PKCδ activation. We also found that the AKT/mTOR pathway was negatively regulated by lanatoside C through PKCδ activation. In conclusion, we provide the first demonstration that the anticancer effects of lanatoside C are mainly attributable to PKCδ activation.
    Antiviral Res. 2014 Nov;111:93-9
    Antiviral activity of lanatoside C against dengue virus infection.[Pubmed: 25251726 ]
    Dengue infection poses a serious threat globally due to its recent rapid spread and rise in incidence. Currently, there is no approved vaccine or effective antiviral drug for dengue virus infection. In response to the urgent need for the development of an effective antiviral for dengue virus, the US Drug Collection library was screened in this study to identify compounds with anti-dengue activities.
    METHODS AND RESULTS:
    Lanatoside C, an FDA approved cardiac glycoside was identified as a candidate anti-dengue compound. Our data revealed that lanatoside C has an IC50 of 0.19μM for dengue virus infection in HuH-7 cells. Dose-dependent reduction in dengue viral RNA and viral proteins synthesis were also observed upon treatment with increasing concentrations of lanatoside C. Time of addition study indicated that lanatoside C inhibits the early processes of the dengue virus replication cycle. Furthermore, lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya and Sindbis virus as well as the human enterovirus 71.
    CONCLUSIONS:
    These findings suggest that lanatoside C possesses broad spectrum antiviral activity against several groups of positive-sense RNA viruses.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0151 mL 5.0756 mL 10.1513 mL 20.3025 mL 25.3781 mL
    5 mM 0.203 mL 1.0151 mL 2.0303 mL 4.0605 mL 5.0756 mL
    10 mM 0.1015 mL 0.5076 mL 1.0151 mL 2.0303 mL 2.5378 mL
    50 mM 0.0203 mL 0.1015 mL 0.203 mL 0.4061 mL 0.5076 mL
    100 mM 0.0102 mL 0.0508 mL 0.1015 mL 0.203 mL 0.2538 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    磁麻苷; Cymarin CFN70386 508-77-0 C30H44O9 = 548.7 5mg QQ客服:2056216494
    铃兰毒苷; Convallatoxin CFN70385 508-75-8 C29H42O10 = 550.7 5mg QQ客服:2159513211
    K-毒毛旋花子苷; k-Strophanthoside CFN70338 33279-57-1 C42H64O19 = 873.0 5mg QQ客服:1457312923
    去乙酰毛花苷; Deslanoside CFN91787 17598-65-1 C47H74O19 = 943.09 10mg QQ客服:2056216494
    毛花苷C; Lanatoside C CFN96196 17575-22-3 C49H76O20 = 985.1 20mg QQ客服:1457312923
    杠柳次苷; Periplocymarin CFN93081 32476-67-8 C30H46O8 = 534.69 5mg QQ客服:1457312923
    杠柳毒苷; Periplocin CFN90513 13137-64-9 C36H56O13 = 696.82 20mg QQ客服:3257982914
    Periplogenin 3-[O-beta-glucopyranosyl-(1->4)-beta-sarmentopyranoside]; Periplogenin 3-[O-beta-glucopyranosyl-(1->4)-beta-sarmentopyranoside] CFN90985 1253421-94-1 C36H56O13 = 696.83 10mg QQ客服:3257982914
    洋地黄毒甙; Digitoxin CFN98535 71-63-6 C41H64O13 = 764.94 20mg QQ客服:2056216494
    地高辛; Digoxin CFN98536 20830-75-5 C41H64O14 = 780.94 20mg QQ客服:3257982914

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