山香二烯酸

Hyptadienic acid

	产品编号	CFN99387
	CAS编号	128397-09-1
	分子式 = 分子量	C₃₀H₄₆O₄ = 470.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The leaf of Eriobotrya japonica
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
山香二烯酸	CFN99387	128397-09-1	1mg	QQ客服：3257982914
山香二烯酸	CFN99387	128397-09-1	5mg	QQ客服：3257982914
山香二烯酸	CFN99387	128397-09-1	10mg	QQ客服：3257982914
山香二烯酸	CFN99387	128397-09-1	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Warszawski Uniwersytet Medyczny (Poland)

Monash University (Australia)

Centralised Purchases Unit (CPU), B.I.T.S (India)

Sant Gadge Baba Amravati University (India)

Chulalongkorn University (Thailand)

University of Melbourne (Australia)

Universidade Federal de Goias (UFG) (Brazil)

Nicolaus Copernicus Uniwersity (Poland)

Srinakharinwirot University (Thailand)

University of Madras (India)

Johannes Gutenberg University Mainz (JGU) (Germany)

Universidade da Beira Interior (Germany)

Kyushu University (Japan)

Calcutta University (India)

More...

Description:

Hyptadienic acid exhibits moderate cytotoxicity against HepG2 cells.It also shows a marked anti-inflammatory effect, it also exhibits strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter.

Targets:

Immunology & Inflammation related

In vitro:

Pharm. Biol., 2003, 41(5):375-8.

Constituents of Salvia trijuga.[Reference: WebLink]

METHODS AND RESULTS:
A new oleanane-type glycoside, trijugaoside A, together with thirty known compounds, was isolated from the whole plant of Salvia trijuga (Lamiaceae). The structure of the new compound was elucidated on the basis of spectral and chemical evidence.
CONCLUSIONS:
Hyptadienic acid isolated from the plant extract exhibited moderate cytotoxicity against HepG2 cells.

In vivo:

Biosci Biotechnol Biochem. 2004 Jan;68(1):85-90.

Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects.[Pubmed: 14745168]

METHODS AND RESULTS:
Nine triterpene acids, viz., six of the ursane type, ursolic acid (1), corosolic acid (2), 3-epicorosolic acid (3), pomolic acid (4), tormentic acid (5) and hyptadienic acid (6), and three of the oleanane type, oleanolic acid (7), augustic acid (8) and 3-epimaslinic acid (9), among which 1 constituted the most predominant triterpene acid, were isolated and identified from ethanol extracts of the leaves of red perilla [Perilla frutescens (L.) Britton var. acuta Kudo] and green perilla [P. frutescens (L.) Britton var. acuta Kudo forma viridis Makino]. These eight compounds, 1, 2, 4-9, were evaluated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 microg/ear) in mice.
CONCLUSIONS:
All the compounds tested showed a marked anti-inflammatory effect, with a 50% inhibitory dose (ID50) of 0.09-0.3 mg per ear. In addition, an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA showed five compounds, 1-3, 5 and 9, with a potent inhibitory effect on EBV-EA induction (91-93% inhibition at 1x10(3) mol ratio/TPA). Furthermore, compound 5 exhibited strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1245 mL	10.6225 mL	21.245 mL	42.4899 mL	53.1124 mL
5 mM	0.4249 mL	2.1245 mL	4.249 mL	8.498 mL	10.6225 mL
10 mM	0.2124 mL	1.0622 mL	2.1245 mL	4.249 mL	5.3112 mL
50 mM	0.0425 mL	0.2124 mL	0.4249 mL	0.8498 mL	1.0622 mL
100 mM	0.0212 mL	0.1062 mL	0.2124 mL	0.4249 mL	0.5311 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
山香二烯酸; Hyptadienic acid	CFN99387	128397-09-1	C₃₀H₄₆O₄ = 470.7	5mg	QQ客服：1413575084
Rosamultic acid; Rosamultic acid	CFN92608	214285-76-4	C₃₀H₄₆O₅ = 486.7	5mg	QQ客服：1457312923