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  • 羟基芫花素

    Hydroxygenkwanin

    羟基芫花素
    产品编号 CFN98021
    CAS编号 20243-59-8
    分子式 = 分子量 C16H12O6 = 300.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Lobelia chinensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    羟基芫花素 CFN98021 20243-59-8 10mg QQ客服:1413575084
    羟基芫花素 CFN98021 20243-59-8 20mg QQ客服:1413575084
    羟基芫花素 CFN98021 20243-59-8 50mg QQ客服:1413575084
    羟基芫花素 CFN98021 20243-59-8 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Rio de Janeiro State University (Brazil)
  • University of Parma (Italy)
  • Shanghai University of TCM (China)
  • University of Limpopo (South Africa)
  • Seoul National University of Science and Technology (Korea)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Monash University (Australia)
  • Medical University of Gdansk (Poland)
  • Harvard University (USA)
  • Kyung Hee University (Korea)
  • Indian Institute of Science (India)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Lund University (Sweden)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nutrients.2018, 10(10)
  • Cell Physiol Biochem.2019, 52(6):1255-1266
  • Life (Basel).2022, 12(12):2107.
  • Evid Based Complement Alternat Med.2021, 2021:5023536.
  • Nutrients.2021, 13(10):3414.
  • J Mol Med (Berl).2018, 96(7):661-672
  • Biomedicines.2020, 8(11):486.
  • Phytochem Anal.2013, 24(5):493-503
  • Food Funct.2022, 13(23):12105-12120.
  • Theoretical and Experimental Plant Physiology 2022, 34,53-62
  • Industrial Crops and Products2020, 146:112186
  • Korean J Dent Mater.2018, 45(2):139-146
  • bioRxiv-Pharm.&Toxi.2022, 2022.481203.
  • Chemistry of Plant Materials.2019, 215-222
  • Foods2023, 12(23), 4342.
  • Pharm Biol.2017, 55(1):360-366
  • Indian J Pharm Sci.2022, 84(4): 874-882.
  • Phytochemistry Letters2015, 243-247
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • Molecules.2020, 25(23):5636.
  • JLiquid Chromatography & Related Tech.2021, 10826076.
  • J Ethnopharmacol.2016, 192:370-381
  • Front Plant Sci.2021, 12: 648426.
  • ...
  • 生物活性
    Description: Hydroxygenkwanin has cytotoxicity, may be an effective natural product to treat glioma, and the combination of Apigenin and Hydroxygenkwanin may be a promising method for glioma chemotherapy.
    Targets: TNF-α | Caspase | BID | BAK | BCL-XL
    In vitro:
    Chem Biol Interact. 2013 Nov 25;206(2):346-55.
    Synergistic anti-glioma effect of Hydroxygenkwanin and Apigenin in vitro.[Pubmed: 24144774]
    Apigenin (AP) and Hydroxygenkwanin (HGK) are two natural flavonoid compounds. Previous studies have already demonstrated the anti-tumor capability of AP. However, it is not clear whether Hydroxygenkwanin has such property.
    METHODS AND RESULTS:
    In the current study, the anti-glioma activities of Hydroxygenkwanin and its synergistic anti-glioma effects with AP on C6 glioma cells were investigated. In addition, the possible mechanisms were also studied. MTT assay and morphologic analysis including acridine orange/ethidium bromide (AO/EB) and 4',6-diamidino-2-phenylindole (DAPI) staining were used in the research, and the results indicated that the treatment with AP or Hydroxygenkwanin could inhibit C6 glioma cell proliferation respectively. Moreover, when AP was administrated simultaneously, the anti-glioma effect of Hydroxygenkwanin was dramatically enhanced in a dose-dependent manner, which is obviously better than that of carmustine (BCNU) at the concentration 25μM for treating of 24h. Compared with control, mitochondrial membrane potential (MPP) loss and mitochondrion damage were detected by JC-1 fluorescence probes (JC-1) and transmission electron microscopy (TEM) after treatment. Obvious DNA damage and cell cycle S phase arrest were detected by alkaline comet assay and flow cytometric analysis (FCM). Additionally, up regulation of TNF-α level, activations of caspase-3, -8, over expressions of BID and BAK protein and BCL-XL protein down expression were also observed after treatment by the combination of AP and Hydroxygenkwanin .
    CONCLUSIONS:
    The results indicate that Hydroxygenkwanin may be an effective natural product to treat glioma, and the combination of AP and Hydroxygenkwanin may be a promising method for glioma chemotherapy.
    Front Oncol . 2019 Sep 18;9:911.
    Anticancer Effect and Mechanism of Hydroxygenkwanin in Oral Squamous Cell Carcinoma[Pubmed: 31620368]
    Abstract The incidence and mortality of oral squamous cell carcinoma (OSCC) are high, and the number of oral cancers had risen in the world. However, chemotherapy drugs have numerous side effects. There is an urgent requirement to develop a novel drug that can be used to treat oral cancer. Hydroxygenkwanin (HGK) is a nature flavonoid extracted from Daphne genkwa Sieb. et Zucc. (Thymelaeaceae). Previous studies had demonstrated that HGK exhibits anticancer effect, but the effect is still unclear in oral cancer. HGK inhibited cell growth dose-dependently in SAS and OCEM1 cells. The functional enrichment analysis showed the significant pathway in cellular movement, cell cycle and cellular growth and proliferation. We further demonstrated the HGK induced the cell cycle arrest by flow cytometry and inhibited colony formation ability and cell movement. The western blot showed that HGK induced cell cycle arrest through p21 activation and caused intrinsic cell apoptosis pathway. HGK inhibited the cell invasion and migration through down-regulation vimentin. HGK might be an effective natural product for oral cancer therapy. Keywords: RNA sequencing; apoptosis; cell cycle; invasion; migration; oral cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.33 mL 16.65 mL 33.3 mL 66.6001 mL 83.2501 mL
    5 mM 0.666 mL 3.33 mL 6.66 mL 13.32 mL 16.65 mL
    10 mM 0.333 mL 1.665 mL 3.33 mL 6.66 mL 8.325 mL
    50 mM 0.0666 mL 0.333 mL 0.666 mL 1.332 mL 1.665 mL
    100 mM 0.0333 mL 0.1665 mL 0.333 mL 0.666 mL 0.8325 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    木犀草素; 3',4',5,7-四羟基黄酮; Luteolin CFN98784 491-70-3 C15H10O6 = 286.2 20mg QQ客服:1413575084
    羟基芫花素; Hydroxygenkwanin CFN98021 20243-59-8 C16H12O6 = 300.3 20mg QQ客服:2159513211
    5,7-二甲氧基木犀草素; 5,7-Dimethoxyluteolin CFN91001 N/A C17H14O6 = 314.3 10mg QQ客服:215959384
    5,6,3',4'-四羟基-7-甲氧基黄酮; Pedalitin CFN96045 22384-63-0 C16H12O7 = 316.3 5mg QQ客服:2056216494
    泽兰黄酮; 6-甲氧基藤黄菌素; 6-Methoxyluteolin CFN92706 520-11-6 C16H12O7 = 316.3 20mg QQ客服:1413575084
    条叶蓟素; Cirsiliol CFN96508 34334-69-5 C17H14O7 = 330.29 5mg QQ客服:2159513211
    Leucanthogenin; Leucanthogenin CFN92953 99615-00-6 C17H14O8 = 346.29 5mg QQ客服:215959384
    毒马草黄酮; Sideritoflavone CFN96399 70360-12-2 C18H16O8 = 360.3 5mg QQ客服:2159513211
    栀子黄素D; Gardenin D CFN95133 29202-00-4 C19H18O8 = 374.4 5mg QQ客服:2159513211
    香叶木素; Diosmetin CFN90210 520-34-3 C16H12O6 = 300.26 20mg QQ客服:2056216494

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