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  • 羟基-α-山椒素

    Hydroxy-alpha-sanshool

    羟基-α-山椒素
    产品编号 CFN91131
    CAS编号 83883-10-7
    分子式 = 分子量 C16H25NO2 = 263.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The fruits of Zanthoxylum bungeanum Maxim.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    羟基-α-山椒素 CFN91131 83883-10-7 1mg QQ客服:2056216494
    羟基-α-山椒素 CFN91131 83883-10-7 5mg QQ客服:2056216494
    羟基-α-山椒素 CFN91131 83883-10-7 10mg QQ客服:2056216494
    羟基-α-山椒素 CFN91131 83883-10-7 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Hamdard University (India)
  • Rio de Janeiro State University (Brazil)
  • Medical University of South Carolina (USA)
  • Sanford Burnham Medical Research Institute (USA)
  • University of Toronto (Canada)
  • Medizinische Universit?t Wien (Austria)
  • Shanghai Institute of Organic Chemistry (China)
  • Universidade do Porto (Portugal)
  • Massachusetts General Hospital (USA)
  • Deutsches Krebsforschungszentrum (Germany)
  • Griffith University (Australia)
  • MTT Agrifood Research Finland (Finland)
  • Mendel University in Brno (Czech Republic)
  • Imperial College London (United Kingdom)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Curr Top Med Chem.2020, 20(21):1898-1909.
  • Exp Neurobiol.2018, 27(3):200-209
  • Planta Medica International2022, 9(01):e108-e115.
  • Nutrients.2021, 13(3):978.
  • Plants (Basel).2022, 11(16):2126.
  • J AOAC Int.2021, 104(6):1634-1651.
  • Appl. Sci.2020, 10(5),1713.
  • Appl Microbiol Biotechnol.2024, 108(1):207.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
  • J Nat Prod.2017, 80(4):854-863
  • Pharmaceutics.2020, 12(9):882.
  • Front Neurosci.2019, 13:1091
  • Food Addit Contam Part A.2021, 38(12):1985-1994.
  • Toxins (Basel).2019, 11(10):E575
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • Biochemistry.2018, 57(40):5886-5896
  • Front Pharmacol.2021, 12:615157.
  • J Bone Miner Res.2017, 32(12):2415-2430
  • Wageningen University & Research2018, January 2018
  • Pharmacognosy Magazine2018, 14(56):418-424
  • Proc Natl Acad Sci USA.2016, 113(30):E4407-1
  • Korean Herb. Med. Inf.2020, 8(2):205-213
  • ...
  • 生物活性
    Description: Hydroxy-alpha-sanshool exerts antiobesity and hypolipidemic activities in HFD rats by reducing liver oxidative stress and thus could be considered as a potential candidate drug to cure or prevent obesity and hyperlipidemia. It also has analgesic properties, it activates TRPV1 and TRPA1 in sensory neurons.
    Targets: TRPV1 | TRPA1 | LDL
    In vivo:
    Biophysical Journal, 2012, 102(3):323a.
    The Plant-Derived Alkylamide, Hydroxy-Alpha-Sanshool, Induces Analgesia through Inhibition of Voltage-Gated Sodium Channels[Reference: WebLink]
    Many native cultures use extracts from Xanthozylum plants to topically treat toothache and joint pain. One active component of these extracts is the alkylamide, Hydroxy-alpha-sanshool, which induces tingling and numbing paresthesia when applied to the skin or tongue. To understand the physiological mechanisms underlying paresthesias, we sought to identify the molecular targets of sanshool in the somatosensory system.
    METHODS AND RESULTS:
    We first measured the analgesic properties of sanshool using mouse models of somatosensory behavior. Topical application of sanshool on the hind paw of naïve mice did not alter their sensitivity to noxious thermal or mechanical stimuli. However, in a model of neurogenic inflammation, sanshool acutely suppressed inflammatory hypersensitivity to mechanical force whereas it did not suppress hypersensitivity to heat. These data suggest that sanshool inhibits activity of a subset of sensory neurons that transduce mechanical, but not thermal, stimuli. In cultured dorsal root ganglion (DRG) neurons from mice, sanshool inhibited action potential (AP) firing in a subset of medium-to-large diameter neurons, which are thought to mediate mechanotransduction. In contrast, sanshool did not inhibit AP firing in small-diameter sensory neurons, which predominantly transduce noxious heat. In addition to size, sensory neurons are distinct in their expression of sensory neuron-specific voltage-gated sodium channels. Thus the differential effect of sanshool on sensory neurons may be due to selective activity of sanshool on different sodium channels. To test this idea, we compared the effects of sanshool on two sodium channel subtypes that are expressed in sensory neurons, Nav1.7 and 1.8. Sanshool reduced the magnitude of Nav1.7 and Nav1.8 currents but caused a hyperpolarizing shift in the steady-state inactivation curve of Nav1.7 only.
    CONCLUSIONS:
    Thus intrinsic molecular differences between sensory neurons, such as expression of different sodium channel subtypes, may underlie specificity of sanshool action.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.7965 mL 18.9825 mL 37.9651 mL 75.9301 mL 94.9127 mL
    5 mM 0.7593 mL 3.7965 mL 7.593 mL 15.186 mL 18.9825 mL
    10 mM 0.3797 mL 1.8983 mL 3.7965 mL 7.593 mL 9.4913 mL
    50 mM 0.0759 mL 0.3797 mL 0.7593 mL 1.5186 mL 1.8983 mL
    100 mM 0.038 mL 0.1898 mL 0.3797 mL 0.7593 mL 0.9491 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    槲皮万寿菊素; Quercetagetin CFN93336 90-18-6 C15H10O8 = 318.23 20mg QQ客服:1413575084
    Stephavanine; Stephavanine CFN98425 33116-33-5 C26H27NO9 = 497.5 5mg QQ客服:2159513211
    丹参新酮, 次丹参醌; Miltirone CFN98531 27210-57-7 C19H22O2 = 282.38 10mg QQ客服:2056216494
    克班宁; Crebanine CFN98275 25127-29-1 C20H21NO4 = 339.4 20mg QQ客服:215959384

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