Info: Read More
  • 中药标准品生产商,产品定制服务
  • (4E)-1,7-双(3,4-二羟基苯基)-4-庚烯-3-酮


    产品编号 CFN98646
    CAS编号 41137-87-5
    分子式 = 分子量 C19H20O5 = 328.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The leaves of Alnus nepalensis
    产品名称 产品编号 CAS编号 包装 QQ客服
    (4E)-1,7-双(3,4-二羟基苯基)-4-庚烯-3-酮 CFN98646 41137-87-5 1mg QQ客服:215959384
    (4E)-1,7-双(3,4-二羟基苯基)-4-庚烯-3-酮 CFN98646 41137-87-5 5mg QQ客服:215959384
    (4E)-1,7-双(3,4-二羟基苯基)-4-庚烯-3-酮 CFN98646 41137-87-5 10mg QQ客服:215959384
    (4E)-1,7-双(3,4-二羟基苯基)-4-庚烯-3-酮 CFN98646 41137-87-5 20mg QQ客服:215959384
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: 或

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • University of Wuerzburg (Germany)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Lund University (Sweden)
  • Ain Shams University (Egypt)
  • The University of Newcastle (Australia)
  • University of Amsterdam (Netherlands)
  • Massachusetts General Hospital (USA)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Sapienza University of Rome (Italy)
  • University of East Anglia (United Kingdom)
  • The Ohio State University (USA)
  • Georgia Institute of Technology (USA)
  • Anna University (India)
  • Aveiro University (Portugal)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Ethnopharmacol.2019, 241:112025
  • Agronomy2020, 10(10),1489
  • J Pharm Biomed Anal2016, 118:183-194
  • J Exp Bot.2016, 67(12):3777-88
  • Journal of Ginseng Research2021, 15 June.
  • Exp Parasitol.2018, 194:67-78
  • Natural Product Communications2020, doi: 10.1177.
  • Food Res Int.2018, 106:909-919
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • Front Cell Dev Biol.2020, 8:32.
  • Drug Des Devel Ther.2020, 14:969-976.
  • Invest New Drugs.2017, 35(2):166-179
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Inflammation2015, 38(1):445-55
  • J. of Med. Plant Research.2013, 90-151
  • Nutrients.2021, 13(10):3414.
  • Plants (Basel).2021, 10(11):2317.
  • Front Pharmacol.2021, 12:652860.
  • Molecules.2021, 26(2):E255.
  • Molecules.2016, 21(6)
  • Fitoterapia.2018, 124:92-102
  • APMIS.2019, 127(10):688-695
  • Polytechnic University of Catalonia2017, 105826
  • ...
  • 生物活性
    Description: Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation.Hirsutenone exhibits anti-cancer, and anti-filarial effects, it may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity.
    Targets: Akt | ERK | EGFR | HO-1 | p53 | mTOR | PI3K | IL Receptor | NF-kB | Antifection
    In vitro:
    J Biol Chem. 2014 Jan 17;289(3):1723-31.
    The diarylheptanoid hirsutenone sensitizes chemoresistant ovarian cancer cells to cisplatin via modulation of apoptosis-inducing factor and X-linked inhibitor of apoptosis.[Pubmed: 24247248]
    Cisplatin (CDDP) and its derivatives are considered first-line treatments for ovarian cancer (OVCA). However, despite initial results that often appear promising, in most cases patients will return with recurrent disease that fails to respond to further chemotherapy.
    We assayed a number of food phytochemicals with reported PI3K inhibitory ability to identify candidates that can influence CDDP treatment outcomes in chemoresistant OVCA cell lines. A direct comparison revealed that the diarylheptanoid hirsutenone from the tree bark of Alnus hirsuta var. sibirica was superior at inducing CDDP sensitivity in a number of chemoresistant cancer cell lines. Whereas hirsutenone treatment activated p53, its modest efficacy in p53-mutant and -null cell lines suggested the existence of a p53-independent mode of action. Further investigation revealed that hirsutenone causes CDDP-dependent apoptosis in chemoresistant cells by ubiquitin-proteasome-dependent X-linked inhibitor of apoptosis degradation and by enhancing the translocation of apoptosis-inducing factor from the mitochondria to the nucleus. This was found to be, at least in part, under the influence of upstream Akt activity, linking hirsutenone-dependent PI3K inhibition with downstream effects on apoptosis-inducing factor, X-linked inhibitor of apoptosis, and apoptosis.
    Our findings provide rationale for further investigation of the effects of hirsutenone on chemoresistant OVCA in clinical studies.
    Int Immunopharmacol. 2010 Apr;10(4):520-5.
    Hirsutenone inhibits lipopolysaccharide-activated NF-kappaB-induced inflammatory mediator production by suppressing Toll-like receptor 4 and ERK activation.[Pubmed: 20138154]
    Adipogenesis is a key driver of the expansion of adipose tissue mass that causes obesity. Hirsutenone (HST) is an active botanical diarylheptanoid present in Alnus species. In this study, we evaluated the effects of HST on adipogenesis, its mechanisms of action and the molecular targets involved.
    Using Oil Red O staining, we observed that HST dose-dependently suppresses lipid accumulation during adipogenesis in 3T3-L1 preadipocytes, concomitant with a decrease in peroxisome proliferator-activated receptor-γ (PPARγ), CCAAT/enhancer-binding protein α (C/EBPα) and fatty acid synthase (FAS) protein expression. This inhibitory effect was largely limited to the early stage of adipogenesis, which includes mitotic clonal expansion (MCE), as evidenced by delayed cell cycle entry of preadipocytes from G1 to S phase. Furthermore, the regulation of MCE was accompanied by suppression of phosphatidylinositol 3-kinase (PI3K) and extracellular-regulated kinase (ERK) activity. HST was also shown to bind directly to PI3K and ERK1 in a non-ATP competitive manner.
    Our results suggest that HST attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of HST in preventing obesity.
    Arch Pharm Res. 2008 Oct;31(10):1287-9.
    Cytotoxic activities of diarylheptanoids from Alnus japonica.[Pubmed: 18958419 ]

    The diarylheptanoids (1-10) 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O-beta-D-glucopyranosyl(1-->3)-beta-D-xylopyranoside (1), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O-beta-D-apiofuranosyl(1-->6)-beta-D-glucopyranoside (2), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-5-O-beta-D-glucopyranoside (3), 1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane (4), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-beta-D-glucopyranoside (5), oregonin (6), hirsutanonol (7), Hirsutenone (8), 1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane-3-O-beta-D-xylopyranoside (9), and platyphylloside (10), isolated from the bark of Alnus japonica, were analyzed for their cytotoxic activities on various human and mouse cancer cell lines. The cytotoxic activities of these ten compounds were evaluated against murine B16 melanoma, human SNU-1 gastric cancer, human SNU-354 hepatoma cancer and human SNU-C4 colorectal cell lines.
    The diarylheptanoids showed potent cytotoxic activities against murine B16 melanoma cells and human SNU-C1 gastric cancer cell when the cell viability was analyzed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0451 mL 15.2253 mL 30.4507 mL 60.9013 mL 76.1267 mL
    5 mM 0.609 mL 3.0451 mL 6.0901 mL 12.1803 mL 15.2253 mL
    10 mM 0.3045 mL 1.5225 mL 3.0451 mL 6.0901 mL 7.6127 mL
    50 mM 0.0609 mL 0.3045 mL 0.609 mL 1.218 mL 1.5225 mL
    100 mM 0.0305 mL 0.1523 mL 0.3045 mL 0.609 mL 0.7613 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Centrolobol; Centrolobol CFN98383 30359-01-4 C19H24O3 = 300.4 5mg QQ客服:2159513211
    1,7-双(4-羟基苯基)庚-6-烯-3-醇; 1,7-Bis(4-hydroxyphenyl)hept-6-en-3-ol CFN97928 1083195-05-4 C19H22O3 = 298.4 5mg QQ客服:2159513211
    1,7-双(4-羟基苯基)庚-1-烯-3-酮; 1,7-Bis(4-hydroxyphenyl)hept-1-en-3-one CFN99088 1083200-79-6 C19H20O3 = 296.4 5mg QQ客服:3257982914
    1,7-双(4-羟基苯基)-4-庚烯-3-酮; Platyphyllenone CFN98955 56973-65-0 C19H20O3 = 296.4 5mg QQ客服:3257982914
    1,7-双(4-羟基苯基)庚-6-烯-3-酮; 1,7-Bis(4-hydroxyphenyl)hept-6-en-3-one CFN96302 1251830-57-5 C19H20O3 = 296.4 5mg QQ客服:215959384
    Rubranol; Rubranol CFN98060 211126-61-3 C19H24O5 = 332.4 5mg QQ客服:2159513211
    (4E)-1,7-双(3,4-二羟基苯基)-4-庚烯-3-酮; Hirsutenone CFN98646 41137-87-5 C19H20O5 = 328.4 5mg QQ客服:1413575084
    1,7-双-(4-羟苯基)-3,5-庚二醇; Hannokinol CFN96248 79120-40-4 C19H24O4 = 316.4 5mg QQ客服:2932563308
    5-羟基-1,7-双(4-羟基苯基)庚烷-3-乙酸酯; 5-Hydroxy-1,7-bis(4-hydroxyphenyl)heptan-3-yl acetate CFN96291 1269839-24-8 C21H26O5 = 358.4 5mg QQ客服:215959384
    内消旋-1,7-双-(4-羟苯基)-3,5-庚二醇; meso-Hannokinol CFN90864 N/A C19H24O4 = 316.4 5mg QQ客服:215959384





    在线QQ: 1413575084


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产