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  • 4-[(3R,5R)-3,5-二羟基-7-(4-羟基苯基)庚基]-1,2-苯二酚

    • 4-[(3R,5R)-3,5-二羟基-7-(4-羟基苯基)庚基]-1,2-苯二酚

    3,5-Dihydroxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane

    4-[(3R,5R)-3,5-二羟基-7-(4-羟基苯基)庚基]-1,2-苯二酚
    		产品编号 CFN96858
    CAS编号 408324-00-5
    分子式 = 分子量 C19H24O5 = 332.39
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Phenols
    植物来源 The rhizomes of Curcuma comosa Roxb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4-[(3R,5R)-3,5-二羟基-7-(4-羟基苯基)庚基]-1,2-苯二酚 CFN96858 408324-00-5 1mg QQ客服：1413575084
    4-[(3R,5R)-3,5-二羟基-7-(4-羟基苯基)庚基]-1,2-苯二酚 CFN96858 408324-00-5 5mg QQ客服：1413575084
    4-[(3R,5R)-3,5-二羟基-7-(4-羟基苯基)庚基]-1,2-苯二酚 CFN96858 408324-00-5 10mg QQ客服：1413575084
    4-[(3R,5R)-3,5-二羟基-7-(4-羟基苯基)庚基]-1,2-苯二酚 CFN96858 408324-00-5 20mg QQ客服：1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Auburn University (USA)
  • Universiti Sains Malaysia (Malaysia)
  • University of Auckland (New Zealand)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Amity University (India)
  • Universidad Veracuzana (Mexico)
  • Ateneo de Manila University (Philippines)
  • St. Jude Children Research Hospital (USA)
  • Universite de Lille1 (France)
  • Universitas Airlangga (Indonesia)
  • Michigan State University (USA)
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  • Shanghai Institute of Organic Chemistry (China)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Chem.2023, 11:1245071.
  • Nutrients.2019, 11(4):E936
  • Pharmacia2024, 71:1-9.
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • TCI CO.2019, US20190151281A1
  • J Pharmaceut Biomed2020, 178:112894
  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • Int J Mol Sci.2019, 20(21):E5488
  • Chem Res Toxicol. 2022, acs.chemrestox.2c00049.
  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
  • Biomed Chromatogr.2022, 36(11):e5462.
  • Int J Biol Macromol.2020, 161:1230-1239.
  • Exp Parasitol.2018, 194:67-78
  • Comparative Clinical Pathology 2021, 30:961-971.
  • National University of Pharmacy2022, 1:73-76
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • ScientificWorldJournal.2022, 2022:4806889.
  • Int J Mol Sci.2023, 24(8):7300.
  • J Sep Sci.2018, 41(7):1682-1690
  • Biomolecules2021, 11(10),1513.
  • Proc Biol Sci.2024, 291:20232298.
  • Molecules.2020, 25(20):4851.
  • Universitat Stuttgart2022, opus-12200.
  • ...
    • 生物活性
    Description: (3R,5R)-3,5-dihydroxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-heptane may have anti-adipogenic activity.
    In vivo:
    Journal of Proteome Research, 2018:acs.jproteome.8b00028.
    Multiplatform Metabolomics Investigation of Anti-Adipogenic Effects on 3T3-L1 Adipocytes by a Potent Diarylheptanoid.[Reference: WebLink]
    Obesity is fast becoming a serious health problem worldwide. Of the many possible anti-obesity strategies, one interesting approach focuses on blocking adipocyte differentiation and lipid accumulation to counteract the rise in fat storage. However, there is currently no drug available for the treatment of obesity that works by inhibiting adipocyte differentiation.
    CONCLUSIONS:
    Here we use a broad-based metabolomics approach to interrogate and better understand metabolic changes that occur during adipocyte differentiation. In particular, we focus on changes induced by the anti-adipogenic diarylheptanoid, which was isolated from a traditional Chinese medicine Dioscorea zingiberensis and identified as (3R,5R)-3,5-dihydroxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane (1). Targeted aqueous metabolic profiling indicated that a total of 14 metabolites involved in the TCA cycle, glycolysis, amino acid metabolism, and purine catabolism participate in regulating energy metabolism, lipogenesis, and lipolysis in adipocyte differentiation and can be modulated by diarylheptanoid 1. As indicated by lipidomics analysis, diarylheptanoid 1 restored the quantity and degree of unsaturation of long chain free fatty acids, and restored the levels of 171 lipids mainly from 10 lipid species in adipocytes. In addition, carbohydrate metabolism in diarylheptanoid 1 treated adipocytes further demonstrated the delayed differentiation process by flux analysis.
    CONCLUSIONS:
    Our results provide valuable information for further understanding the metabolic adjustment in adipocytes subjected to diarylheptanoid 1 treatment. Moreover, this study offers new insight into developing anti-adipogenic leading compounds based on metabolomics.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0085 mL 15.0426 mL 30.0851 mL 60.1703 mL 75.2129 mL
    5 mM 0.6017 mL 3.0085 mL 6.017 mL 12.0341 mL 15.0426 mL
    10 mM 0.3009 mL 1.5043 mL 3.0085 mL 6.017 mL 7.5213 mL
    50 mM 0.0602 mL 0.3009 mL 0.6017 mL 1.2034 mL 1.5043 mL
    100 mM 0.0301 mL 0.1504 mL 0.3009 mL 0.6017 mL 0.7521 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1,7-双(4-羟基苯基)-4-庚烯-3-酮; Platyphyllenone CFN98955 56973-65-0 C19H20O3 = 296.4 5mg QQ客服：3257982914
    (4E,6E)-1,7-二(4-羟基苯基)-4,6-庚二烯-3-酮; 1,7-Bis(4-hydroxyphenyl)hepta-4,6-dien-3-one CFN96790 332371-82-1 C19H18O3 = 294.35 5mg QQ客服：215959384
    1,7-双(4-羟基苯基)庚-6-烯-3-酮; 1,7-Bis(4-hydroxyphenyl)hept-6-en-3-one CFN96302 1251830-57-5 C19H20O3 = 296.4 5mg QQ客服：215959384
    Rubranol; Rubranol CFN98060 211126-61-3 C19H24O5 = 332.4 5mg QQ客服：2159513211
    (4E)-1,7-双(3,4-二羟基苯基)-4-庚烯-3-酮; Hirsutenone CFN98646 41137-87-5 C19H20O5 = 328.4 5mg QQ客服：2056216494
    1,7-双-(4-羟苯基)-3,5-庚二醇; Hannokinol CFN96248 79120-40-4 C19H24O4 = 316.4 10mg QQ客服：215959384
    4-[(3R,5R)-3,5-二羟基-7-(4-羟基苯基)庚基]-1,2-苯二酚 ; 3,5-Dihydroxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane CFN96858 408324-00-5 C19H24O5 = 332.39 5mg QQ客服：1413575084
    5-羟基-1,7-双(4-羟基苯基)庚烷-3-乙酸酯; 5-Hydroxy-1,7-bis(4-hydroxyphenyl)heptan-3-yl acetate CFN96291 1269839-24-8 C21H26O5 = 358.4 10mg QQ客服：3257982914
    内消旋-1,7-双-(4-羟苯基)-3,5-庚二醇; meso-Hannokinol CFN90864 N/A C19H24O4 = 316.4 5mg QQ客服：3257982914
    阔叶酮醇; Platyphyllonol CFN98644 41137-85-3 C19H22O4 = 314.4 5mg QQ客服：2056216494

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