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  • 太子参环肽B

    • 太子参环肽B

    Heterophyllin B

    太子参环肽B
    		产品编号 CFN90627
    CAS编号 145459-19-4
    分子式 = 分子量 C40H58N8O8 = 778.95
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Pseudostellaria heterophylla.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    太子参环肽B CFN90627 145459-19-4 10mg QQ客服：2159513211
    太子参环肽B CFN90627 145459-19-4 20mg QQ客服：2159513211
    太子参环肽B CFN90627 145459-19-4 50mg QQ客服：2159513211
    太子参环肽B CFN90627 145459-19-4 100mg QQ客服：2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Asian J Beauty Cosmetol2022, 20(2):183-191
  • Molecules.2019, 24(20):3755
  • Food Funct.2021, 12(4):1469-1481.
  • Pharmaceuticals (Basel).2022, 15(8):982.
  • Nutrients.2023, 15(12):2644.
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  • Food Chem Toxicol.2024, 186:114589.
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  • University of East Anglia2023, 93969.
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  • ...
    • 生物活性
    Description: Heterophyllin B is used as the quality control index for evaluating P. heterophylla in the Chinese Pharmacopoeia.Heterophyllin B effectively suppresses the adhesion and invasion of the human esophageal carcinoma cells by mediating the PI3K/AKT/β-catenin pathways and regulating the expression levels of adhesion- and invasion-associated genes.
    Targets: PI3K | Akt | Wnt/β-catenin | MMP(e.g.TIMP)
    In vitro:
    Mol Med Rep. 2016 Feb;13(2):1097-104.
    Heterophyllin B inhibits the adhesion and invasion of ECA-109 human esophageal carcinoma cells by targeting PI3K/AKT/β-catenin signaling.[Pubmed: 26647768 ]
    The present study aimed to measure the effect of Heterophyllin B (HB) on the adhesion and invasion of ECA-109 human esophageal carcinoma cells, and examine the possible mechanism involved.
    METHODS AND RESULTS:
    A Cell Counting kit 8 assay was performed to determine the cell viability. Cell adhesion and invasion were determined following treatment of the ECA-109 cells with HB (0, 10, 25 and 50 μM) for 24 h. The levels of phosphorylated (p-)ATK and p-phosphoinositide 3-kinase (PI3K), and the protein levels of β-catenin were measured using western blot analysis. The mRNA and protein expression levels of E-cadherin, vimentin, snail, matrix metalloproteinase (MMP)2 and MMP9 were detected using reverse transcription-quantitative polymerase chain reaction and western blot analyses, respectively. HB (10, 25 and 50 μM) significantly suppressed the adhesion and invasion of the ECA-109 human esophageal carcinoma cells in a dose-dependant manner. The expression levels of p-ATK, p-PI3K and β-catenin were markedly decreased. The expression of E-cadherin was promoted, whereas the expression levels of snail, vimentin, MMP 2 and MMP 9 were decreased significantly in the ECA-109 cells treated with HB. In addition, HB inhibited the adhesion and invasion induced by PI3K activating peptide in the ECA-109 cells, and the protein expression levels were also adjusted.
    CONCLUSIONS:
    These results suggested that HB effectively suppressed the adhesion and invasion of the human esophageal carcinoma cells by mediating the PI3K/AKT/β-catenin pathways and regulating the expression levels of adhesion- and invasion-associated genes.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2838 mL 6.4189 mL 12.8378 mL 25.6756 mL 32.0945 mL
    5 mM 0.2568 mL 1.2838 mL 2.5676 mL 5.1351 mL 6.4189 mL
    10 mM 0.1284 mL 0.6419 mL 1.2838 mL 2.5676 mL 3.2094 mL
    50 mM 0.0257 mL 0.1284 mL 0.2568 mL 0.5135 mL 0.6419 mL
    100 mM 0.0128 mL 0.0642 mL 0.1284 mL 0.2568 mL 0.3209 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Rubiyunnanin C; Rubiyunnanin C CFN91927 1261030-04-9 C43H52N6O11 = 828.91 5mg QQ客服：215959384
    Astin A; Astin A CFN95187 151201-75-1 C25H33N5O7Cl2 = 586.5 10mg QQ客服：2056216494
    Astin B; Astin B CFN95188 151201-76-2 C25H33N5O7Cl2 = 586.5 10mg QQ客服：1457312923
    Astin C; Astin C CFN95189 148057-23-2 C25H33N5O6Cl2 = 570.5 10mg QQ客服：1413575084
    zeta-Clausenamide; zeta-Clausenamide CFN95745 136173-85-8 C18H17NO2 = 279.3 5mg QQ客服：1413575084
    环(D-苯丙氨酸-L-脯氨酸); Cyclo(D-Phe-L-Pro) CFN96110 26488-24-4 C14H16N2O2 = 244.3 10mg QQ客服：2056216494
    环(L-苯丙氨酸-L-脯氨酸)二肽; Cyclo(L-Phe-L-Pro) CFN96129 3705-26-8 C14H16N2O2 = 244.3 10mg QQ客服：1413575084
    环(酪氨酸-脯氨酸)二肽; Cyclo(Tyr-Pro) CFN90276 5654-84-2 C14H16N2O3 = 260.29 10mg QQ客服：215959384
    环(酪氨酸-苯丙氨酸)二肽; Cyclo(Tyr-Phe) CFN90278 5147-17-1 C18H18N2O3 = 310.35 10mg QQ客服：215959384
    3,6-Dibenzyl-2-hydroxy-5-methoxypyrazine; 3,6-Dibenzyl-2-hydroxy-5-methoxypyrazine CFN89034 132213-65-1 C19H18N2O2 = 306.36 5mg QQ客服：2056216494

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