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    • 欧天芥菜碱

    Heleurine

    欧天芥菜碱
    		产品编号 CFN00239
    CAS编号 488-00-6
    分子式 = 分子量 C16H27NO4 = 297.39
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Alkaloids
    植物来源 The herbs of Heliotropium indicum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    欧天芥菜碱 CFN00239 488-00-6 1mg QQ客服：1457312923
    欧天芥菜碱 CFN00239 488-00-6 5mg QQ客服：1457312923
    欧天芥菜碱 CFN00239 488-00-6 10mg QQ客服：1457312923
    欧天芥菜碱 CFN00239 488-00-6 20mg QQ客服：1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Copenhagen University (Denmark)
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  • The University of Newcastle (Australia)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Cell Mol Med.2022, 26(23):5807-5819.
  • J.the Korean Socie. Food Sci.&Nut.2023; 52(1):26-39.
  • PLoS One.2017, 12(3):e0173585
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Drug Dev Res.2022, 83(7):1673-1682.
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Konkuk University2023, 29:4634721
  • Biomolecules.2024, 14(5):589.
  • FEMS Microbiol Lett.2017, 364(11)
  • J of Advanced Scientific R.2020, 11(3), p109-120.
  • Cells.2022, 11(8), 1311.
  • The Korea Journal of Herbology2016, 29-35
  • bioRxiv - Biochemistry2023, 541790.
  • Mutlu Yanic S, Ates EG. JOTCSA.2023, 10(4);893-902.
  • J Nat Med.2018, 72(3):734-744
  • Phytochemistry.2024, 222:114102.
  • Plants (Basel).2023, 12(6):1259.
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • Applied Physics B2021, 127(92).
  • Molecules.2020, 25(23):5556.
  • Mol Pharm.2018, 15(8):3285-3296
  • Agronomy2023, 13(6), 1435.
  • Toxins (Basel).2023, 15(3):231.
  • ...
    • 生物活性
    Description: Heleurine, platyphylline, supinine and cynaustraline are more potent in antagonizing responses to acetylcholine and carbachol than responses to histamine.
    Targets: AChR
    In vitro:
    Br J Pharmacol. 1971 Apr;41(4):683-90.
    Pyrrolizidine alkaloids: actions on muscarinic receptors in the guinea-pig ileum.[Pubmed: 5579465 ]

    METHODS AND RESULTS:
    1. Eleven pyrrolizidine alkaloids have been tested on the isolated guinea-pig ileum preparation.2. Platyphylline, supinine, Heleurine and cynaustraline were more potent in antagonizing responses to acetylcholine and carbachol than responses to histamine. Their anticholinergic activity appeared to involve a competitive mechanism.3. Lasiocarpine, monocrotaline, spectabiline, sarracine, 7-angelylheliotridine, heliotrine and senecionine had similar antagonistic potencies against responses to both acetylcholine and histamine.
    CONCLUSIONS:
    4. The alkaloids had no appreciable activity as antagonists of acetylcholine in the isolated toad rectus abdominis preparation.5. These results are discussed with respect to interactions of the alkaloids at receptor sites involved in anticholinergic activity at the muscarinic receptor.
    In vivo:
    Veterinary and human toxicology 09/2003; 45(4):198-201.
    Toxicity of dietary Heliotropium circinatum to rats.[Reference: WebLink]

    METHODS AND RESULTS:
    Pyrrolizidine alkaloid intoxication was produced in adult, male rats by feeding different levels (0, 1, 3, 5 or 10%) of Heliotropium circinatum for 20 w. Combined GC-MS revealed 0.15% total alkaloid content in the plant material of which 12% and 88% were basic and N-oxide forms, respectively. The specific alkaloids identified were europine (67.33%), heliotrine (16.34%), lasiocarpine (8.12%), heleurine (4.18%), echinatine (1.56%), 7-angeylheliotrine (1.19%), and an unknown alkaloid (1.28%). Neither mortality nor significant clinical changes occurred in test groups. Mild to moderate, dose-related hepatic megalocytosis was the most prominent histopathological finding. In addition to chronic hepatotoxicity, notable medial thickening occurred in the pulmonary arterioles and arteries of the high-dosed groups.
    CONCLUSIONS:
    This study indicated that H. circinatum plant has limited toxic potential in rats with mild to moderate histological changes and no mortality at the dosing levels, total doses, or time of exposure employed.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3626 mL 16.8129 mL 33.6259 mL 67.2518 mL 84.0647 mL
    5 mM 0.6725 mL 3.3626 mL 6.7252 mL 13.4504 mL 16.8129 mL
    10 mM 0.3363 mL 1.6813 mL 3.3626 mL 6.7252 mL 8.4065 mL
    50 mM 0.0673 mL 0.3363 mL 0.6725 mL 1.345 mL 1.6813 mL
    100 mM 0.0336 mL 0.1681 mL 0.3363 mL 0.6725 mL 0.8406 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    倒提壶灵，倒提壶碱; Amabiline CFN00236 17958-43-9 C15H25NO4 = 283.37 5mg QQ客服：2056216494
    琉璃草亭; Cynaustine CFN00237 17958-39-3 C15H25NO4 = 283.37 5mg QQ客服：215959384
    仰卧天芥菜碱; Supinine CFN00238 551-58-6 C15H25NO4 = 283.37 5mg QQ客服：215959384
    欧天芥菜碱; Heleurine CFN00239 488-00-6 C16H27NO4 = 297.39 5mg QQ客服：1413575084
    Absouline; Absouline CFN00240 112513-33-4 C17H22N2O2 = 286.37 5mg QQ客服：3257982914
    Isoabsouline; Isoabsouline CFN00241 112513-34-5 C17H22N2O2 = 286.37 5mg QQ客服：1413575084
    Anchustrigosine; Anchustrigosine CFN00242 N/A C24H41NO8 = 471.59 5mg QQ客服：1457312923
    Assamicadine; Assamicadine CFN00244 126260-96-6 C16H23NO5 = 309.36 5mg QQ客服：1413575084
    Bohemamine; Bohemamine CFN00245 72926-12-6 C14H18N2O3 = 262.30 5mg QQ客服：215959384
    Callimorphine; Callimorphine CFN00246 74991-73-4 C15H23NO5 = 297.35 5mg QQ客服：2056216494

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