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  • 匙羹藤酸I

    • 匙羹藤酸I

    Gymnemic acid I

    匙羹藤酸I
    		产品编号 CFN90538
    CAS编号 122168-40-5
    分子式 = 分子量 C43H66O14 = 806.97
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Gymnema sylvestre (Retz.) Schult.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    匙羹藤酸I CFN90538 122168-40-5 1mg QQ客服：2056216494
    匙羹藤酸I CFN90538 122168-40-5 5mg QQ客服：2056216494
    匙羹藤酸I CFN90538 122168-40-5 10mg QQ客服：2056216494
    匙羹藤酸I CFN90538 122168-40-5 20mg QQ客服：2056216494
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • ...
    • 生物活性
    Description: Gymnemic acid I is a protein biosynthesis inhibitor, it as antisweet principles.
    In vitro:
    Journal of Natural Products,2017, 80(4).
    Determination of Gymnemic Acid I as a Protein Biosynthesis Inhibitor Using Chemical Proteomics.[Reference: WebLink]
    The plant Gymnema sylvestre has been used widely in traditional medicine as a remedy for several diseases, and its leaf extract is known to contain a group of bioactive triterpene saponins belonging to the gymnemic acid class.
    METHODS AND RESULTS:
    Gymnemic acid I (1) is one of the main components among this group of secondary metabolites and is endowed with an interesting bioactivity profile. Since there is a lack of information about its specific biological targets, the full interactome of 1 was investigated through a quantitative chemical proteomic approach, based on stable-isotope dimethyl labeling. The ribosome complex was found to be the main partner of compound 1, and a full validation of the proteomics results was achieved by orthogonal approaches.
    CONCLUSIONS:
    Further biochemical and biological investigations revealed an inhibitory effect of 1 on the ribosome machinery.
    In vivo:
    J Cell Physiol . 2019 Jun;234(6):9370-9377.
    Gymnemic acid I triggers mechanistic target of rapamycin-mediated β cells cytoprotection through the promotion of autophagy under high glucose stress[Pubmed: 30370588]
    Abstract Gymnemic acid I (GA I) is a bioactive component of Gymnema sylvestre. It is an Indian traditional medicinal herb which has antidiabetic effect. However, the molecular mechanism is remaining to be elucidated. Here, we showed that high glucose promoted the rate of apoptosis, GA I decreased the apoptosis under the high glucose stress. Our further study explored that GA I increased the number of autophagosome and the ratio of light chain 3-I (LC3-I)/LC3-II in MIN-6 cells under the normal or high glucose stress by the methods of western blot analysis and immunofluorescence. It induced autophagy flux and inhibited the phosphorylation of mammalian target of rapamycin (mTOR) and ribosomal protein S6 kinase β-1 (p70 S6K/S6K1), which is a substrate of mTOR. GA I decreased the rate of apoptosis and the activity of caspase-3 under the high glucose stress. The inhibition of apoptosis and caspase-3 activity by GA I were increased after treating with autophagy inhibitor in mouse islet β cells MIN-6. Our data suggested that GA I-induced autophagy protected MIN-6 cells from apoptosis under high glucose stress via inhibition the phosphorylation activity of mTOR. Keywords: apoptosis; autophagy; gymnemic acid; high glucose.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2392 mL 6.196 mL 12.392 mL 24.7841 mL 30.9801 mL
    5 mM 0.2478 mL 1.2392 mL 2.4784 mL 4.9568 mL 6.196 mL
    10 mM 0.1239 mL 0.6196 mL 1.2392 mL 2.4784 mL 3.098 mL
    50 mM 0.0248 mL 0.1239 mL 0.2478 mL 0.4957 mL 0.6196 mL
    100 mM 0.0124 mL 0.062 mL 0.1239 mL 0.2478 mL 0.3098 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    柴胡皂苷F; Saikosaponin F CFN90635 62687-63-2 C48H80O17 = 929.14 20mg QQ客服：2159513211
    柴胡皂苷H; Saikosaponin H CFN90902 91990-63-5 C48H78O17 = 927.12 10mg QQ客服：1413575084
    断血流皂苷 A; Clinopodiside A CFN90479 142809-89-0 C48H78O19 = 959.12 20mg QQ客服：215959384
    柴胡皂苷B2; Saikosaponin B2 CFN99126 58316-41-9 C42H68O13 = 780.98 20mg QQ客服：3257982914
    柴胡皂苷B1; Saikosaponin B1 CFN99127 58558-08-0 C42H68O13 = 780.98 20mg QQ客服：1457312923
    醉鱼草皂苷IVb; Buddlejasaponin IVb CFN90709 152580-79-5 C48H78O18 = 943.12 20mg QQ客服：1413575084
    柴胡皂苷A; Saikosaponin A CFN99987 20736-09-8 C42H68O13 = 780.99 20mg QQ客服：2056216494
    2''-O-乙酰柴胡皂苷A; 2''-O-acetylsaikosaponin A CFN95085 102934-42-9 C44H70O14 = 823 5mg QQ客服：1413575084
    6''-O-乙酰柴胡皂苷A; 6''-O-acetylsaikosaponin A CFN95086 64340-46-1 C44H70O14 = 823 10mg QQ客服：215959384
    柴胡皂苷D; Saikosaponin D CFN99989 20874-52-6 C42H68O13 = 780.99 20mg QQ客服：2056216494

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