匙羹藤酸I

Gymnemic acid I

	产品编号	CFN90538
	CAS编号	122168-40-5
	分子式 = 分子量	C₄₃H₆₆O₁₄ = 806.97
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The herbs of Gymnema sylvestre (Retz.) Schult.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
匙羹藤酸I	CFN90538	122168-40-5	1mg	QQ客服：1413575084
匙羹藤酸I	CFN90538	122168-40-5	5mg	QQ客服：1413575084
匙羹藤酸I	CFN90538	122168-40-5	10mg	QQ客服：1413575084
匙羹藤酸I	CFN90538	122168-40-5	20mg	QQ客服：1413575084

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Monash University Sunway Campus (Malaysia)

Biotech R&D Institute (USA)

Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)

Korea Institute of Oriental Medicine (Korea)

Universidade da Beira Interior (Germany)

Universidade Católica Portuguesa (Portugal)

University of Indonesia (Indonesia)

Sapienza University of Rome (Italy)

National Chung Hsing University (Taiwan)

University of Liège (Belgium)

University of Limpopo (South Africa)

Florida International University (USA)

Instytut Nawozów Sztucznych w Pu?awach (Poland)

Technical University of Denmark (Denmark)

More...

Description:

Gymnemic acid I is a protein biosynthesis inhibitor, it as antisweet principles.

In vitro:

Journal of Natural Products,2017, 80(4).

Determination of Gymnemic Acid I as a Protein Biosynthesis Inhibitor Using Chemical Proteomics.[Reference: WebLink]

The plant Gymnema sylvestre has been used widely in traditional medicine as a remedy for several diseases, and its leaf extract is known to contain a group of bioactive triterpene saponins belonging to the gymnemic acid class.
METHODS AND RESULTS:
Gymnemic acid I (1) is one of the main components among this group of secondary metabolites and is endowed with an interesting bioactivity profile. Since there is a lack of information about its specific biological targets, the full interactome of 1 was investigated through a quantitative chemical proteomic approach, based on stable-isotope dimethyl labeling. The ribosome complex was found to be the main partner of compound 1, and a full validation of the proteomics results was achieved by orthogonal approaches.
CONCLUSIONS:
Further biochemical and biological investigations revealed an inhibitory effect of 1 on the ribosome machinery.

In vivo:

J Cell Physiol . 2019 Jun;234(6):9370-9377.

Gymnemic acid I triggers mechanistic target of rapamycin-mediated β cells cytoprotection through the promotion of autophagy under high glucose stress[Pubmed: 30370588]

Abstract Gymnemic acid I (GA I) is a bioactive component of Gymnema sylvestre. It is an Indian traditional medicinal herb which has antidiabetic effect. However, the molecular mechanism is remaining to be elucidated. Here, we showed that high glucose promoted the rate of apoptosis, GA I decreased the apoptosis under the high glucose stress. Our further study explored that GA I increased the number of autophagosome and the ratio of light chain 3-I (LC3-I)/LC3-II in MIN-6 cells under the normal or high glucose stress by the methods of western blot analysis and immunofluorescence. It induced autophagy flux and inhibited the phosphorylation of mammalian target of rapamycin (mTOR) and ribosomal protein S6 kinase β-1 (p70 S6K/S6K1), which is a substrate of mTOR. GA I decreased the rate of apoptosis and the activity of caspase-3 under the high glucose stress. The inhibition of apoptosis and caspase-3 activity by GA I were increased after treating with autophagy inhibitor in mouse islet β cells MIN-6. Our data suggested that GA I-induced autophagy protected MIN-6 cells from apoptosis under high glucose stress via inhibition the phosphorylation activity of mTOR. Keywords: apoptosis; autophagy; gymnemic acid; high glucose.

信息支持

公司简介
订购流程
付款方式
退换货政策

ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

联系方式

电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com

湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2392 mL	6.196 mL	12.392 mL	24.7841 mL	30.9801 mL
5 mM	0.2478 mL	1.2392 mL	2.4784 mL	4.9568 mL	6.196 mL
10 mM	0.1239 mL	0.6196 mL	1.2392 mL	2.4784 mL	3.098 mL
50 mM	0.0248 mL	0.1239 mL	0.2478 mL	0.4957 mL	0.6196 mL
100 mM	0.0124 mL	0.062 mL	0.1239 mL	0.2478 mL	0.3098 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
杏黄罂粟碱; Armepavine	CFN93348	524-20-9	C₁₉H₂₃NO₃ = 313.39	10mg	QQ客服：2159513211
皂草苷；皂草黄苷; Saponarin	CFN90134	20310-89-8	C₂₇H₃₀O₁₅ = 594.52	10mg	QQ客服：3257982914
文多灵; Vindoline	CFN98083	2182-14-1	C₂₅H₃₂N₂O₆ = 456.5	20mg	QQ客服：2056216494
1-羟基吴茱萸次碱; 1-Hydroxyrutaecarpine	CFN98895	53600-24-1	C₁₈H₁₃N₃O₂ = 303.3	5mg	QQ客服：1413575084