苯甲酰芽子碱

Benzoylecgonine

	产品编号	CFN00191
	CAS编号	519-09-5
	分子式 = 分子量	C₁₆H₁₉NO₄ = 289.33
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The herbs of Erythroxylum coca
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产品名称	产品编号	CAS编号	包装	QQ客服
苯甲酰芽子碱	CFN00191	519-09-5	1mg	QQ客服：2159513211
苯甲酰芽子碱	CFN00191	519-09-5	5mg	QQ客服：2159513211
苯甲酰芽子碱	CFN00191	519-09-5	10mg	QQ客服：2159513211
苯甲酰芽子碱	CFN00191	519-09-5	20mg	QQ客服：2159513211

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Description:

Benzoylecgonine, validated methodologies from matrices other than blood that can be obtained in the autopsy room would be useful to the forensic toxicologist in the evaluation of a specific forensic case. Benzoylecgonine causes oxidative stress, it and oxytocin increase myometrial contractility, while atosiban and ritodrine induce myometrial relaxation.

In vitro:

Drug Test Anal. 2013 Aug;5(8):646-56.

A redox proteomic investigation of oxidative stress caused by benzoylecgonine in the freshwater bivalve Dreissena polymorpha.[Pubmed: 22991338]

Drugs of abuse and their human metabolites have been recently recognized as emerging environmental contaminants. Notwithstanding the fact that these kinds of compounds share some features with pharmaceuticals, their ecotoxicology has not yet been extensively investigated, although some of their characteristics may potentially threaten aquatic ecosystems. One of the most abundant drugs found in rivers and wastewaters is benzoylecgonine (BE), the main metabolite of cocaine.
METHODS AND RESULTS:
We applied a redox proteomics approach to evaluate changes in the proteome of Dreissena polymorpha exposed to two different concentrations of BE (0.5 and 1 µg/l). Exposures were performed in vivo for a period of 14 days and the effect of oxidative stress on protein thiol and carbonyl groups in mussel gills were evaluated. One-dimensional electrophoresis did not reveal a reduction in protein thiol content but showed a significant increase of protein carbonylation at both doses tested. Then, protein profiling using two-dimensional gel electrophoresis was performed with subsequent matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF) and TOF/TOF with LIFT technique and linear ion trap combined with orbitrap mass spectrometer (LTQ-Orbitrap).
CONCLUSIONS:
This yielded de novo protein sequences suitable for database searching. These preliminary results and protein identifications obtained suggest that BE causes oxidative stress. Oxidative modifications were detected in differing classes of proteins such as those of the cytoskeleton, energetic metabolism and stress response.

In vivo:

J Forensic Leg Med. 2014 Mar;23:37-43.

Determination of cocaine and its major metabolite benzoylecgonine in several matrices obtained from deceased individuals with presumed drug consumption prior to death.[Pubmed: 24661704]

In particular, when femoral blood is unavailable for analysis for the presence of systemic exposure to cocaine and its principal metabolite, Benzoylecgonine, validated methodologies from matrices other than blood that can be obtained in the autopsy room would be useful to the forensic toxicologist in the evaluation of a specific forensic case.
METHODS AND RESULTS:
To address this issue, we implemented and compared in our study the systematic evaluation of extraction, chromatographic separation, and quantification of cocaine and Benzoylecgonine in different biological matrices (right and left cardiac blood, femoral arterial and venous blood, urine, vitreous humor, cerebrospinal fluid, brain accumbens nucleus, brain ventral tegmental area, and liver).
CONCLUSIONS:
The methods were applied to evaluate a thanatological case using all the study matrices, showing unequal postmortem distribution of cocaine and Benzoylecgonine throughout the different matrices tested.

Am J Forensic Med Pathol. 2015 Jun;36(2):84-7.

The effect of chronic renal failure on the benzoylecgonine blood level: a case report.[Pubmed: 25881815]

Chronic renal failure results in reduced elimination of a variety of substances within the blood, including numerous drugs and their metabolites.
METHODS AND RESULTS:
This report describes a case of a man who died in jail, after less than 48 hours of being incarcerated, wherein postmortem toxicology testing revealed a blood benzoylecgonine level of 0.25 mg/L with no cocaine detected, suggesting possible recent cocaine use in jail.
CONCLUSIONS:
Autopsy and investigation revealed severe underlying cardiovascular disease and dialysis-dependent CRF, thus accounting for the elevated benzoylecgonine levels and allaying concerns that the man obtained and used cocaine in jail.

Analyst. 2015 Sep 21;140(18):6254-9.

Rapid detection of cocaine, benzoylecgonine and methylecgonine in fingerprints using surface mass spectrometry.[Pubmed: 25977942]

Latent fingerprints provide a potential route to the secure, high throughput and non-invasive detection of drugs of abuse.
METHODS AND RESULTS:
In this study we show for the first time that the excreted metabolites of drugs of abuse can be detected in fingerprints using ambient mass spectrometry. Fingerprints and oral fluid were taken from patients attending a drug and alcohol treatment service. Gas chromatography mass spectrometry (GC-MS) was used to test the oral fluid of patients for the presence of cocaine and benzoylecgonine. The corresponding fingerprints were analysed using Desorption Electrospray Ionization (DESI) which operates under ambient conditions and Ion Mobility Tandem Mass Spectrometry Matrix Assisted Laser Desorption Ionization (MALDI-IMS-MS/MS) and Secondary Ion Mass Spectrometry (SIMS). The detection of cocaine, benzoylecgonine (BZE) and methylecgonine (EME) in latent fingerprints using both DESI and MALDI showed good correlation with oral fluid testing. The sensitivity of SIMS was found to be insufficient for this application.
CONCLUSIONS:
These results provide exciting opportunities for the use of fingerprints as a new sampling medium for secure, non-invasive drug detection. The mass spectrometry techniques used here offer a high level of selectivity and consume only a small area of a single fingerprint, allowing repeat and high throughput analyses of a single sample.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.4563 mL	17.2813 mL	34.5626 mL	69.1252 mL	86.4065 mL
5 mM	0.6913 mL	3.4563 mL	6.9125 mL	13.825 mL	17.2813 mL
10 mM	0.3456 mL	1.7281 mL	3.4563 mL	6.9125 mL	8.6407 mL
50 mM	0.0691 mL	0.3456 mL	0.6913 mL	1.3825 mL	1.7281 mL
100 mM	0.0346 mL	0.1728 mL	0.3456 mL	0.6913 mL	0.8641 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Darlingine; Darlingine	CFN00188	58471-10-6	C₁₃H₁₇NO₂ = 219.28	5mg	QQ客服：1413575084
芽子碱; Ecgonine	CFN00189	481-37-8	C₉H₁₅NO₃ = 185.22	5mg	QQ客服：215959384
芽子碱甲酯; Methylecgonine	CFN00190	7143-09-1	C₁₀H₁₇NO₃ = 199.25	5mg	QQ客服：215959384
苯甲酰芽子碱; Benzoylecgonine	CFN00191	519-09-5	C₁₆H₁₉NO₄ = 289.33	5mg	QQ客服：1457312923
桂皮酰古柯碱; Cinnamoylcocaine	CFN00192	521-67-5	C₁₉H₂₃NO₄ = 329.4	5mg	QQ客服：215959384
Knightinol; Knightinol	CFN00196	77053-06-6	C₁₇H₂₃NO₃ = 289.37	5mg	QQ客服：1457312923
Acetylknightinol; Acetylknightinol	CFN00197	77053-07-7	C₁₉H₂₅NO₄ = 331.41	5mg	QQ客服：215959384
6-beta-羟基莨菪碱; 6-beta-Hydroxyhyoscyamine	CFN00198	55869-99-3	C₁₇H₂₃NO₄ = 305.37	5mg	QQ客服：215959384
旋花碱; Convolvine	CFN00186	537-30-4	C₁₆H₂₁NO₄ = 291.34	5mg	QQ客服：1413575084
旋花胺; Convolamine	CFN00187	500-56-1	C₁₇H₂₃NO₄ = 305.37	5mg	QQ客服：215959384

苯甲酰芽子碱

Benzoylecgonine

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