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    Caffeine

    咖啡因
    产品编号 CFN99004
    CAS编号 58-08-2
    分子式 = 分子量 C8H10N4O2 = 194.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The seeds of Theobroma cacao L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    咖啡因 CFN99004 58-08-2 10mg QQ客服:1413575084
    咖啡因 CFN99004 58-08-2 20mg QQ客服:1413575084
    咖啡因 CFN99004 58-08-2 50mg QQ客服:1413575084
    咖啡因 CFN99004 58-08-2 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Kyung Hee University (Korea)
  • University of Leipzig (Germany)
  • University of Wuerzburg (Germany)
  • University of Auckland (New Zealand)
  • Weizmann Institute of Science (Israel)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • University of South Australia (Australia)
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  • Ain Shams University (Egypt)
  • Universitas islam negeri Jakarta (Indonesia)
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  • FORTH-IMBB (Greece)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Biomol Struct Dyn.2022, 1-21.
  • Antioxidants (Basel).2020, 9(2):E120
  • Fitoterapia.2024, 175:105955.
  • Exp Ther Med.2019, 18(6):4388-4396
  • Journal of Ginseng Research2024, 03.005.
  • Food Funct.2022, doi: 10.1039
  • Pharmaceuticals (Basel).2024, 17(3):352.
  • Nutrients.2017, 10(1)
  • Int. J. Mol. Sci.2022, 23(14),7699;
  • Nutr Cancer.2022, 1-13.
  • Int J Mol Sci.2022, 23(13):7115.
  • Evid Based Complement Alternat Med.2017, 2017:1583185
  • Eur J Neurosci.2021, 53(11):3548-3560.
  • Comparative Clinical Pathology 2021, 30:961-971.
  • Phytother Res.2019, 33(3):676-689
  • Acta Chromatographica2021, 00960.
  • The Journal of Korean Medicine2023, 44(4):26-40.
  • LWT2021, 138:110630.
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • Research Square2020, doi: 10.21203.
  • Nutrients.2023, 15(12):2644.
  • Environ Toxicol.2023, 38(7):1641-1650.
  • Oncol Lett.2020, 20(4):122.
  • ...
  • 生物活性
    Description: Caffeine has anxiolytic-like activity, can have both positive and negative effects on anxiety. It inhibits glucose transport by binding at the GLUT1 nucleotide-binding site.
    Targets: Estrogen receptor | GLUT | Progestogen receptor
    In vivo:
    Am J Physiol Cell Physiol. 2015 Feb 25
    Caffeine inhibits glucose transport by binding at the GLUT1 nucleotide-binding site.[Pubmed: 25715702]
    Glucose transporter 1 (GLUT1) is the primary glucose transport protein of the cardiovascular system and astroglia. A recent study proposes that caffeine uncompetitive inhibition of GLUT1 results from interactions at an exofacial GLUT1 site. Intracellular ATP is also an uncompetitive GLUT1 inhibitor and shares structural similarities with caffeine, suggesting that caffeine acts at the previously characterized endofacial GLUT1 nucleotide-binding site.
    METHODS AND RESULTS:
    We tested this by confirming that caffeine uncompetitively inhibits GLUT1-mediated 3-O-methylglucose uptake in human erythrocytes [Vmax and Km for transport are reduced fourfold; Ki(app) = 3.5 mM caffeine]. ATP and AMP antagonize caffeine inhibition of 3-O-methylglucose uptake in erythrocyte ghosts by increasing Ki(app) for caffeine inhibition of transport from 0.9 ± 0.3 mM in the absence of intracellular nucleotides to 2.6 ± 0.6 and 2.4 ± 0.5 mM in the presence of 5 mM intracellular ATP or AMP, respectively. Extracellular ATP has no effect on sugar uptake or its inhibition by caffeine. Caffeine and ATP displace the fluorescent ATP derivative, trinitrophenyl-ATP, from the GLUT1 nucleotide-binding site, but d-glucose and the transport inhibitor cytochalasin B do not. Caffeine, but not ATP, inhibits cytochalasin B binding to GLUT1. Like ATP, caffeine renders the GLUT1 carboxy-terminus less accessible to peptide-directed antibodies, but cytochalasin B and d-glucose do not.
    CONCLUSIONS:
    These results suggest that the caffeine-binding site bridges two nonoverlapping GLUT1 endofacial sites-the regulatory, nucleotide-binding site and the cytochalasin B-binding site. Caffeine binding to GLUT1 mimics the action of ATP but not cytochalasin B on sugar transport. Molecular docking studies support this hypothesis.
    Neuroscience. 2015 Feb 11. pii: S0306-4522(15)00146-3.
    Anxiolytic-like, stimulant and neuroprotective effects of Ilex paraguariensis extracts in mice.[Pubmed: 25681522]
    Yerba-mate (Ilex paraguariensis St. Hil.) is the most used beverage in Latin America with approximately 426 thousand of tons consumed per year. Considering the broad use of this plant, we aimed to investigate the anxiety-like and stimulant activity of both the hydroethanolic (HE) and aqueous (AE) extracts from leaves of I. paraguariensis.
    METHODS AND RESULTS:
    Swiss mice were treated with I. paraguariensis HE or AE chronically or acutely, respectively, followed by evaluation in the elevated plus-maze (EPM; anxiety-like paradigm), open field (OF; locomotor activity) or the step-down avoidance task (memory assessment). Following behavioral protocols the brains were collected for evaluation of acetylcholinesterase (AChE) activity ex vivo. Chronic treatment with HE induced an anxiolytic-like effect and increased motor activity besides augmented AChE activity. Additionally, acute treatment with AE prevented the scopolamine-induced memory deficit in the step-down avoidance task.
    CONCLUSIONS:
    Overall, our results indicate the importance of the I. paraguariensis-induced CNS effects, since it is a widely used nutraceutical. We have reported anxiolytic, stimulant and neuroprotective effects for this plant species. These effects are potentially modulated by the cholinergic system as well as by caffeine.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.1493 mL 25.7467 mL 51.4933 mL 102.9866 mL 128.7333 mL
    5 mM 1.0299 mL 5.1493 mL 10.2987 mL 20.5973 mL 25.7467 mL
    10 mM 0.5149 mL 2.5747 mL 5.1493 mL 10.2987 mL 12.8733 mL
    50 mM 0.103 mL 0.5149 mL 1.0299 mL 2.0597 mL 2.5747 mL
    100 mM 0.0515 mL 0.2575 mL 0.5149 mL 1.0299 mL 1.2873 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    可可碱; Theobromine CFN99737 83-67-0 C7H8N4O2 = 180.16 20mg QQ客服:3257982914
    茶碱; Theophylline CFN99768 58-55-9 C7H8N4O2 = 180.16 20mg QQ客服:1413575084
    腺嘌呤; Adenine CFN89041 73-24-5 C5H5N5 = 135.13 20mg QQ客服:2159513211
    S-(5'-腺苷基)-L-氯化蛋氨酸; S-(5'-Adenosyl)-L-methionine chloride CFN90073 24346-00-7 C15H23ClN6O5S = 434.9 10mg QQ客服:3257982914
    S-腺甙甲硫氨酸对甲苯磺酸盐; S-Adenosyl-L-methionine tosylate CFN90074 71914-80-2 C22H30N6O8S2 = 570.6 5mg QQ客服:2159513211
    S-腺苷蛋氨酸; S-Adenosyl-L-Methtonine CFN90075 17176-17-9 C15H22N6O5S = 398.44 20mg QQ客服:2056216494
    S-腺苷基-L-蛋氨碘盐; S-Adenosyl-L-Methionine iodide salt CFN90076 3493-13-8 C15H23IN6O5S.I = 526.3 5mg QQ客服:1457312923
    Zarzissine; Zarzissine CFN96195 160568-14-9 C5H5N5 = 135.1 5mg QQ客服:2159513211
    鸟嘌呤核苷; Guanosine CFN90925 118-00-3 C10H13N5O5 = 283.2 20mg QQ客服:1413575084
    2'-脱氧鸟苷; 2'-Deoxyguanosine CFN91545 312693-72-4 C10H13N5O4 = 267.2 20mg QQ客服:2159513211

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