番石榴二醛B
Guajadial B
|
产品编号 |
CFN96065 |
CAS编号 |
1414455-03-0 |
分子式 = 分子量 |
C30H34O5 = 474.6 |
产品纯度 |
>=98% |
物理属性 |
Powder |
化合物类型 |
Sesquiterpenoids |
植物来源 |
The herbs of Psidium guajava |
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
番石榴二醛B |
CFN96065 |
1414455-03-0 |
1mg |
QQ客服:3257982914 |
番石榴二醛B |
CFN96065 |
1414455-03-0 |
5mg |
QQ客服:3257982914 |
番石榴二醛B |
CFN96065 |
1414455-03-0 |
10mg |
QQ客服:3257982914 |
番石榴二醛B |
CFN96065 |
1414455-03-0 |
20mg |
QQ客服:3257982914 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
University of Illinois at Chicago (USA)
University of South Australia (Australia)
University of Beira Interior (Portugal)
Centralised Purchases Unit (CPU), B.I.T.S (India)
Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
University of the Basque Country (Spain)
Guangzhou Institutes of Biomedicine and Health (China)
University of Lodz (Poland)
Instituto Politécnico de Bragan?a (Portugal)
University of Maryland School of Medicine (USA)
Universiti Sains Malaysia (Malaysia)
Imperial College London (United Kingdom)
University of Vienna (Austria)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
Description: |
Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines, it is the most effective having an IC50 value of 150 nM toward A549 cells.
|
Targets: |
Topoisomerase |
In vitro: |
J Agric Food Chem. 2017 Jun 21;65(24):4993-4999. | Meroterpenoids with Antitumor Activities from Guava (Psidium guajava).[Pubmed: 28578580] | Psidium guajava L., a species native to South America, has been widely cultivated in the tropical and subtropical areas of China for its popular fruits. METHODS AND RESULTS: The preliminary analysis by liquid chromatography-ultraviolet (LC-UV) indicated the presence of meroterpenoids in the fruits of P. guajava (guava). Subsequent fractionation of the petroleum ether extract resulted in the identification of two new meroterpenoids, psiguajavadials A (1) and B (2), together with 14 previously described meroterpenoids (3-16). Their structures were fully elucidated by comprehensive spectroscopic techniques and theoretical calculations. All of the meroterpenoids showed cytotoxicities against five human cancer cell lines, with Guajadial B (12) being the most effective having an IC50 value of 150 nM toward A549 cells. Furthermore, biochemical topoisomerase I (Top1) assay revealed that psiguajavadial A (1), psiguajavadial B (2), Guajadial B (12), guajadial C (14), and guajadial F (16) acted as Top1 catalytic inhibitors and delayed Top1 poison-mediated DNA damage.
CONCLUSIONS:
The flow cytometric analysis indicated that the new meroterpenoids psiguajavadials A (1) and B (2) could induce apoptosis of HCT116 cells. These data suggest that meroterpenoids from guava fruit could be used for the development of antitumor agents. |
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|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
2.107 mL |
10.5352 mL |
21.0704 mL |
42.1408 mL |
52.6759 mL |
5 mM |
0.4214 mL |
2.107 mL |
4.2141 mL |
8.4282 mL |
10.5352 mL |
10 mM |
0.2107 mL |
1.0535 mL |
2.107 mL |
4.2141 mL |
5.2676 mL |
50 mM |
0.0421 mL |
0.2107 mL |
0.4214 mL |
0.8428 mL |
1.0535 mL |
100 mM |
0.0211 mL |
0.1054 mL |
0.2107 mL |
0.4214 mL |
0.5268 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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