| Description: |
Globularin has hypoglycaemic and hypolipidemic activities in normal and streptozotocin-induced diabetic rats. |
| In vitro: |
| Phytochemistry. 2003 Sep;64(2):529-33. | | Aragoside and iridoid glucosides from Aragoa cundinamarcensis.[Pubmed: 12943770] |
METHODS AND RESULTS:
From the water-soluble part of an extract of Aragoa cundinamarcensis were isolated seven iridoid glucosides, namely aucubin, catalpol, rehmannioside D, Globularin, gardoside methyl ester, epiloganin and mussaenoside. The main glycoside isolated, however, was a new caffeoyl phenylethanoid triglycoside, named aragoside, containing two beta-gluco- and one alpha-arabinopyranosyl moieties which constituted almost 5% of the dry weight of the plant. Finally, sorbitol was found to be the main carbohydrate constituent of the plant. This distinctive combination of compounds is very similar to that reported from some species of Plantago.
CONCLUSIONS:
The present findings therefore support the results from a recently published molecular phylogenetic study of plastid and nuclear ribosomal DNA sequences, where Aragoa was found to be the closest relative to Plantago so far discovered. |
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| In vivo: |
| J. Appl. Pharm.Sci., 2013,03(4):001-7. | | Evaluation of hypoglycaemic and hypolipidemic activities of Globularin isolated from Globularia alypum L. In normal and streptozotocin-induced diabetic rats[Reference: WebLink] | The present study investigates the effect of intraperitoneal administration of Globularin on blood glucose levelsin normal and streptozotocin diabetic rats.
METHODS AND RESULTS:
Globularin was an iridoid glucoside which was isolated from theleaves of Globularia alypum (3.4 %). This compound was identified by means of physical constants andspectral data UV, IR, MS, 1H-NMR, 13C-NMR, DEPT, COSY, HMBC. The acute toxicity test demonstrated thatGlobularin is not lethal up to dose of 1000 mg/kg body weight after intraperitoneal injection. In normal andstreptozotocin diabetic rats, single intraperitoneal administration of Globularin at a dose 100 mg/kg body weightproduced significant decrease of blood glucose levels. However, in prolonged treatment study, the repeatedintraperitoneal administration of Globularin (2 x 100 mg/kg body weight) decreased significantly the bloodglucose levels when compared to the diabetic control rats. In addition, daily injection of Globularin (2 x 100mg/kg body weight) reduced significantly serum levels of total cholesterol (varied from 0.53 to 0.41 g/L) andtriglycerides (varied from 1.71 to 0.79 g/L) in the diabetic rats. |
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