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  • Gelsemiol

    Gelsemiol

    Gelsemiol
    产品编号 CFN99205
    CAS编号 110414-77-2
    分子式 = 分子量 C10H16O4 = 200.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Iridoids
    植物来源 The herbs of Verbena littoralis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Gelsemiol CFN99205 110414-77-2 1mg QQ客服:2932563308
    Gelsemiol CFN99205 110414-77-2 5mg QQ客服:2932563308
    Gelsemiol CFN99205 110414-77-2 10mg QQ客服:2932563308
    Gelsemiol CFN99205 110414-77-2 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Vienna (Austria)
  • Universite de Lille1 (France)
  • Universidad de Antioquia (Colombia)
  • Indian Institute of Science (India)
  • Cornell University (USA)
  • Universidade do Porto (Portugal)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • FORTH-IMBB (Greece)
  • Florida A&M University (USA)
  • Chang Gung University (Taiwan)
  • University of Leipzig (Germany)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Chulalongkorn University (Thailand)
  • Imperial College London (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2021, 12:770667.
  • Evid Based Complement Alternat Med.2021, 2021:5023536.
  • Exp Biol Med (Maywood).2019, 244(16):1463-1474
  • Cardiovasc Toxicol.2021, 21(11):947-963.
  • J Biosci.2020, 45:46.
  • J Ethnopharmacol.2016, 192:370-381
  • Cancers (Basel).2021, 13(9):2223.
  • Reprod Toxicol.2020, 96:1-10.
  • Foods.2021, 10(6):1378.
  • Korean Journal of Pharmacognosy2018, 49(1):76-83
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • LWT2020, 130:109535
  • Oncotarget.2017, 8(53):90925-90947
  • Drug Des Devel Ther.2020, 14:61-71
  • Life Sci.2018, 209:498-506
  • Appl. Sci.2020, 10(20), 7323.
  • Plant Direct.2021, 5(4):e00318.
  • Molecules 2021, 26(4),1092.
  • J of Applied Biological Chem.2020, 63(2):147-152
  • Int J Mol Sci.2021, 22(19):10220.
  • Phytomedicine.2022, 96:153877.
  • Univerzita Karlova2022, 228192.
  • J Food Biochem.2020, 44(6):e13198.
  • ...
  • 生物活性
    Description: Gelsemiol has neurotrophic factor-potentiating activity, markedly enhances an increase in the proportion of neurite-bearing cells and an extension of the neurite length in the presence of nerve growth factor.
    Targets: NGF
    In vitro:
    J Pharm Pharmacol. 2001 Jun;53(6):915-9.
    Potentiation of nerve growth factor-induced elongation of neurites by gelsemiol and 9-hydroxysemperoside aglucone in PC12D cells.[Pubmed: 11428671]

    METHODS AND RESULTS:
    In PC12D cells, nerve growth factor (NGF) increased the proportion of neurite-bearing cells and made neurites longer. A methanol extract of Verbena littoralis H. B. K. collected in Paraguay only slightly potentiated the proportion of PC12D cells with neurites but markedly increased the length of neurites in the presence of NGF (2 ng mL(-1)). The methanol extract was partitioned between ethyl acetate and water followed by further extraction of water fraction with n-butanol. The potentiating activity of NGF-action was observed in the ethyl acetate and n-butanol fractions. The n-butanol fraction was separated by silica gel chromatography, monitoring the NGF-potentiating activity to give Gelsemiol and 9-hydroxysemperoside aglucone (9-OHSA). Neither compound (30-300 microM) exhibited neurite-inducing activity alone. Gelsemiol (100-300 microM) markedly enhanced an increase in the proportion of neurite-bearing cells and an extension of the neurite length in the presence of NGF (2 ng mL(-1)). Interestingly, in the presence of NGF (2 ng mL(-1)), 9-OHSA (100-300 microM) enhanced the elongation of neurites without affecting the increase in the proportion of cells with neurites.
    CONCLUSIONS:
    These results suggested that Gelsemiol and 9-OHSA were major active components of V. littoralis in the NGF-potentiating action. It was possible that the mechanism of neurite elongation by NGF was different from that of the increase in the proportion of neurite-bearing cells, and that 9-OHSA selectively affected the neurite elongation mechanism.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.995 mL 24.975 mL 49.95 mL 99.9001 mL 124.8751 mL
    5 mM 0.999 mL 4.995 mL 9.99 mL 19.98 mL 24.975 mL
    10 mM 0.4995 mL 2.4975 mL 4.995 mL 9.99 mL 12.4875 mL
    50 mM 0.0999 mL 0.4995 mL 0.999 mL 1.998 mL 2.4975 mL
    100 mM 0.05 mL 0.2498 mL 0.4995 mL 0.999 mL 1.2488 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Gelsemiol; Gelsemiol CFN99205 110414-77-2 C10H16O4 = 200.2 5mg QQ客服:1148253675
    巴戟醚萜; Borreriagenin CFN98272 249916-07-2 C10H14O5 = 214.2 5mg QQ客服:3257982914
    车叶草苷; Asperuloside CFN99467 14259-45-1 C18H22O11 = 414.4 20mg QQ客服:3257982914
    鸡屎藤苷; Paederoside CFN92523 20547-45-9 C18H22O11S = 446.4 20mg QQ客服:2159513211
    10-O-香豆酰-10-O-去乙酰车叶草苷; 10-O-Coumaroyl-10-O-deacetylasperuloside CFN89334 903519-82-4 C25H26O12 = 518.47 5mg QQ客服:215959384

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