Gelsemiol

	产品编号	CFN99205
	CAS编号	110414-77-2
	分子式 = 分子量	C₁₀H₁₆O₄ = 200.2
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Iridoids
	植物来源	The herbs of Verbena littoralis
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Gelsemiol	CFN99205	110414-77-2	1mg	QQ客服：3257982914
Gelsemiol	CFN99205	110414-77-2	5mg	QQ客服：3257982914
Gelsemiol	CFN99205	110414-77-2	10mg	QQ客服：3257982914
Gelsemiol	CFN99205	110414-77-2	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
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PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universit?t Basel (Switzerland)

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Heidelberg University (Germany)

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Nicolaus Copernicus Uniwersity (Poland)

Kyung Hee University (Korea)

Institute of Chinese Materia Medica (China)

Sapienza University of Rome (Italy)

University of British Columbia (Canada)

Auburn University (USA)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

Yale University (USA)

Cornell University (USA)

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Description:

Gelsemiol has neurotrophic factor-potentiating activity, markedly enhances an increase in the proportion of neurite-bearing cells and an extension of the neurite length in the presence of nerve growth factor.

Targets:

NGF

In vitro:

J Pharm Pharmacol. 2001 Jun;53(6):915-9.

Potentiation of nerve growth factor-induced elongation of neurites by gelsemiol and 9-hydroxysemperoside aglucone in PC12D cells.[Pubmed: 11428671]

METHODS AND RESULTS:
In PC12D cells, nerve growth factor (NGF) increased the proportion of neurite-bearing cells and made neurites longer. A methanol extract of Verbena littoralis H. B. K. collected in Paraguay only slightly potentiated the proportion of PC12D cells with neurites but markedly increased the length of neurites in the presence of NGF (2 ng mL(-1)). The methanol extract was partitioned between ethyl acetate and water followed by further extraction of water fraction with n-butanol. The potentiating activity of NGF-action was observed in the ethyl acetate and n-butanol fractions. The n-butanol fraction was separated by silica gel chromatography, monitoring the NGF-potentiating activity to give Gelsemiol and 9-hydroxysemperoside aglucone (9-OHSA). Neither compound (30-300 microM) exhibited neurite-inducing activity alone. Gelsemiol (100-300 microM) markedly enhanced an increase in the proportion of neurite-bearing cells and an extension of the neurite length in the presence of NGF (2 ng mL(-1)). Interestingly, in the presence of NGF (2 ng mL(-1)), 9-OHSA (100-300 microM) enhanced the elongation of neurites without affecting the increase in the proportion of cells with neurites.
CONCLUSIONS:
These results suggested that Gelsemiol and 9-OHSA were major active components of V. littoralis in the NGF-potentiating action. It was possible that the mechanism of neurite elongation by NGF was different from that of the increase in the proportion of neurite-bearing cells, and that 9-OHSA selectively affected the neurite elongation mechanism.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Gelsemiol; Gelsemiol	CFN99205	110414-77-2	C₁₀H₁₆O₄ = 200.2	5mg	QQ客服：215959384
巴戟醚萜; Borreriagenin	CFN98272	249916-07-2	C₁₀H₁₄O₅ = 214.2	5mg	QQ客服：1413575084
车叶草苷; Asperuloside	CFN99467	14259-45-1	C₁₈H₂₂O₁₁ = 414.4	20mg	QQ客服：2159513211
鸡屎藤苷; Paederoside	CFN92523	20547-45-9	C₁₈H₂₂O₁₁S = 446.4	20mg	QQ客服：1413575084
10-O-香豆酰-10-O-去乙酰车叶草苷; 10-O-Coumaroyl-10-O-deacetylasperuloside	CFN89334	903519-82-4	C₂₅H₂₆O₁₂ = 518.47	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.995 mL	24.975 mL	49.95 mL	99.9001 mL	124.8751 mL
5 mM	0.999 mL	4.995 mL	9.99 mL	19.98 mL	24.975 mL
10 mM	0.4995 mL	2.4975 mL	4.995 mL	9.99 mL	12.4875 mL
50 mM	0.0999 mL	0.4995 mL	0.999 mL	1.998 mL	2.4975 mL
100 mM	0.05 mL	0.2498 mL	0.4995 mL	0.999 mL	1.2488 mL