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  • 灵芝烯酸D

    Ganoderenic acid D

    灵芝烯酸D
    产品编号 CFN90300
    CAS编号 100665-43-8
    分子式 = 分子量 C30H40O7 = 512.64
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝烯酸D CFN90300 100665-43-8 1mg QQ客服:2159513211
    灵芝烯酸D CFN90300 100665-43-8 5mg QQ客服:2159513211
    灵芝烯酸D CFN90300 100665-43-8 10mg QQ客服:2159513211
    灵芝烯酸D CFN90300 100665-43-8 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Chung Hsing University (Taiwan)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • University of Amsterdam (Netherlands)
  • Utah State University (USA)
  • University of Wisconsin-Madison (USA)
  • University of Lodz (Poland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Neurosci.2019, 13:1091
  • Chem. of Vegetable Raw Materials2020, 97-105
  • Front Pharmacol.2021, 12:690113.
  • Front Pharmacol.2021, 12:744624.
  • J of App. Res. on Med&Aromatic Plants2020, 100291.
  • Applied Biological Chemistry2022, 71:s13765-022-00743-5.
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • J Agric Food Chem.2020, 68(51):15164-15175
  • Food Chem.2021, 360:130063.
  • Kangwon National University2022, 37(1):29-37
  • Separations2021, 8(1), 1.
  • Curr Top Med Chem.2020, 20(21):1898-1909.
  • Molecules.2021, 26(4):817.
  • Semyung University2017, 149407
  • Plants (Basel).2022, 11(16):2126.
  • Molecules.2021, 26(9):2526.
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • Natural Product Communications2020, doi: 10.1177.
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Nat Chem Biol.2018, 14(8):760-763
  • BMC Complement Med Ther. 2020, 20(1):94.
  • Nutrients.2021, 13(1):254.
  • Curr Eye Res.2018, 43(1):27-34
  • ...
  • 生物活性
    Description: Ganoderenic acid D is most cytotoxic with IC50 values of 0.14 ± 0.01, 0.18 ± 0.02 and 0.26 ± 0.03 mg/mL in Hep G2, Hela and Caco-2 cells, respectively.
    In vivo:
    J Ethnopharmacol . 2018 Jan 10;210:287-295.
    Network pharmacology analysis of the anti-cancer pharmacological mechanisms of Ganoderma lucidum extract with experimental support using Hepa1-6-bearing C57 BL/6 mice[Pubmed: 28882624]
    Abstract Ethnopharmacological relevance: Ganoderma lucidum (GL) is an oriental medical fungus, which was used to prevent and treat many diseases. Previously, the effective compounds of Ganoderma lucidum extract (GLE) were extracted from two kinds of GL, [Ganoderma lucidum (Leyss. Ex Fr.) Karst.] and [Ganoderma sinense Zhao, Xu et Zhang], which have been used for adjuvant anti-cancer clinical therapy for more than 20 years. However, its concrete active compounds and its regulation mechanisms on tumor are unclear. Aim of the study: In this study, we aimed to identify the main active compounds from GLE and to investigate its anti-cancer mechanisms via drug-target biological network construction and prediction. Materials and methods: The main active compounds of GLE were identified by HPLC, EI-MS and NMR, and the compounds related targets were predicted using docking program. To investigate the functions of GL holistically, the active compounds of GL and related targets were predicted based on four public databases. Subsequently, the Identified-Compound-Target network and Predicted-Compound-Target network were constructed respectively, and they were overlapped to detect the hub potential targets in both networks. Furthermore, the qRT-PCR and western-blot assays were used to validate the expression levels of target genes in GLE treated Hepa1-6-bearing C57 BL/6 mice. Results: In our work, 12 active compounds of GLE were identified, including Ganoderic acid A, Ganoderenic acid A, Ganoderic acid B, Ganoderic acid H, Ganoderic acid C2, Ganoderenic acid D, Ganoderic acid D, Ganoderenic acid G, Ganoderic acid Y, Kaemferol, Genistein and Ergosterol. Using the docking program, 20 targets were mapped to 12 compounds of GLE. Furthermore, 122 effective active compounds of GL and 116 targets were holistically predicted using public databases. Compare with the Identified-Compound-Target network and Predicted-Compound-Target network, 6 hub targets were screened, including AR, CHRM2, ESR1, NR3C1, NR3C2 and PGR, which was considered as potential markers and might play important roles in the process of GLE treatment. GLE effectively inhibited tumor growth in Hepa1-6-bearing C57 BL/6 mice. Finally, consistent with the results of qRT-PCR data, the results of western-blot assay demonstrated the expression levels of PGR and ESR1 were up-regulated, as well as the expression levels of NR3C2 and AR were down-regulated, while the change of NR3C1 and CHRM2 had no statistical significance. Conclusions: The results indicated that these 4 hub target genes, including NR3C2, AR, ESR1 and PGR, might act as potential markers to evaluate the curative effect of GLE treatment in tumor. And, the combined data provide preliminary study of the pharmacological mechanisms of GLE, which may be a promising potential therapeutic and chemopreventative candidate for anti-cancer. Keywords: Cancer; Ergosterol (PubChem CID: 444679); Ganoderenic acid A (PubChem CID: 6442088); Ganoderenic acid D (PubChem CID: 101600080); Ganoderenic acid G (PubChem CID: 14193981); Ganoderic acid A (PubChem CID: 471002); Ganoderic acid B (PubChem CID: 471003); Ganoderic acid C2 (PubChem CID: 57396771); Ganoderic acid D (PubChem CID: 102004379); Ganoderic acid H (PubChem CID: 471005); Ganoderic acid Y (PubChem CID: 57397445); Ganoderma lucidum; Genistein (PubChem CID: 5281377); Kaemferol (PubChem CID: 5280863); Network pharmacology; Target gene.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9507 mL 9.7534 mL 19.5069 mL 39.0137 mL 48.7672 mL
    5 mM 0.3901 mL 1.9507 mL 3.9014 mL 7.8027 mL 9.7534 mL
    10 mM 0.1951 mL 0.9753 mL 1.9507 mL 3.9014 mL 4.8767 mL
    50 mM 0.039 mL 0.1951 mL 0.3901 mL 0.7803 mL 0.9753 mL
    100 mM 0.0195 mL 0.0975 mL 0.1951 mL 0.3901 mL 0.4877 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝酸G; Ganoderic acid G CFN90801 98665-22-6 C30H44O8 = 532.7 20mg QQ客服:2159513211
    20-羟基灵芝酸G; 20-Hydroxyganoderic acid G CFN91014 400604-12-8 C30H44O9 = 548.67 5mg QQ客服:1457312923
    灵芝酸N; Ganoderic acid N CFN90293 110241-19-5 C30H42O8 = 530.65 10mg QQ客服:1413575084
    灵芝烯酸A; Ganoderenic acid A CFN92236 100665-40-5 C30H42O7 = 514.7 5mg QQ客服:1457312923
    灵芝烯酸D; Ganoderenic acid D CFN90300 100665-43-8 C30H40O7 = 512.64 10mg QQ客服:2056216494
    灵芝烯酸D甲酯; Methyl ganoderenate D CFN95572 748136-03-0 C31H42O7 = 526.7 5mg QQ客服:1457312923
    紫芝烯酸C; Ganosinensic acid C CFN95567 2231756-23-1 C30H40O7 = 512.6 5mg QQ客服:215959384
    灵芝烯酸E; Ganoderenic acid E CFN91024 110241-23-1 C30H40O8 = 528.63 5mg QQ客服:2159513211
    灵芝酸L; Ganoderic acid L CFN95022 102607-24-9 C30H46O8 = 534.7 5mg QQ客服:215959384
    灵芝酸I; Ganoderic acid I CFN90740 98665-20-4 C30H44O8 = 532.67 5mg QQ客服:1413575084

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