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  • Ferruginine

    • Ferruginine

    Ferruginine

    Ferruginine
    		产品编号 CFN00194
    CAS编号 73069-63-3
    分子式 = 分子量 C10H15NO = 165.23
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 From Darlingia ferruginea J. F. Bailey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Ferruginine CFN00194 73069-63-3 1mg QQ客服：2159513211
    Ferruginine CFN00194 73069-63-3 5mg QQ客服：2159513211
    Ferruginine CFN00194 73069-63-3 10mg QQ客服：2159513211
    Ferruginine CFN00194 73069-63-3 20mg QQ客服：2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • University of East Anglia (United Kingdom)
  • National Chung Hsing University (Taiwan)
  • University of Toronto (Canada)
  • Mahatma Gandhi University (India)
  • Celltrion Chemical Research Institute (Korea)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • University of Melbourne (Australia)
  • Copenhagen University (Denmark)
  • Utrecht University (Netherlands)
  • Griffith University (Australia)
  • University of Vigo (Spain)
  • University Medical Center Mainz (Germany)
  • Universidad de La Salle (Mexico)
  • The Institute of Cancer Research (United Kingdom)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • National University of Pharmacy2022, 1:73-76
  • Phytomedicine.2021, 84:153501.
  • Nutrients.2023, 15(4):954.
  • Phytomedicine.2019, 55:229-237
  • Phytomedicine.2019, 61:152813
  • Applied Biological Chemistry 2022, 65,5(2022).
  • Sci Rep.2017, 7(1):3249
  • BMC Complement Altern Med.2018, 18(1):221
  • Food and Fermentation Industries2018, 44(371)
  • Molecules2022, 27(14),4462
  • Antiviral Res.2021, 193:105142.
  • LWT-Food Sci Technol2020, 109163
  • Food Bioscience2022, 50:102187.
  • PLoS One.2021, 16(9):e0257243.
  • Molecules.2019, 24(19):E3417
  • Vietnam Journal of Food Control.2022, 5(3):pp.488-497.
  • Molecules.2023, 28(8):3291.
  • J Control Release.2021, 336:159-168.
  • mBio.2020, 11(3):e00686-20.
  • Heliyon.2023, 9(11):e21944.
  • Invest New Drugs.2017, 35(2):166-179
  • Fitoterapia.2022, 105141.
  • Mol Biol Rep.2024, 51(1):117.
  • ...
    • 生物活性
    Description: Ferruginine-type diazine analogues show moderate affinity for the central alpha4beta2 and remarkably low affinity for the alpha7* nAChR subtypes.
    Targets: AChR
    In vitro:
    Bioorg Med Chem. 2001 Oct;9(10):2683-91.
    Synthesis and evaluation of diazine containing bioisosteres of (-)-ferruginine as ligands for nicotinic acetylcholine receptors.[Pubmed: 11557356]
    In this structure-affinity relationship (SAFIR) study, the bioisosteric potential of diazines in the field of ferruginine-type nAChR ligands was investigated.
    METHODS AND RESULTS:
    Novel enantiopure analogues of (-)-Ferruginine (3) such as 6-8 were synthesized utilizing enantiomerically pure N-protected (+)-2-tropanone 9 from the 'chiral pool' as versatile chiral building block and a palladium-catalyzed Stille cross-coupling of the tributylstannyl diazines 12, 14 and 16 with the vinyl triflate 11 of (+)-2-tropanone 9. The structures of the novel diazine analogues 6-8 of (-)-ferruginine (3) were assigned on the basis of spectral data, that of ligand 7 being additionally verified by X-ray crystallography. The bioisosteric replacement of the acetyl moiety as structural part of the lead compound 3 with the pyridazine, pyrimidine and pyrazine nucleus resulted in ligands with high to moderate affinity for the central alpha4beta2 and remarkably low affinity for the alpha7* nAChR subtypes.
    CONCLUSIONS:
    Among the compounds synthesized and tested, 7 was the most active one with K(i)=3.7 nM (alpha4beta2). Compared with the lead 3, this value represents a 30-fold improvement in the affinity for the alpha4beta2 subtype combined with a substantially improved selectivity ratio between the alpha4beta2 and alpha7* subtypes.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.0522 mL 30.2608 mL 60.5217 mL 121.0434 mL 151.3042 mL
    5 mM 1.2104 mL 6.0522 mL 12.1043 mL 24.2087 mL 30.2608 mL
    10 mM 0.6052 mL 3.0261 mL 6.0522 mL 12.1043 mL 15.1304 mL
    50 mM 0.121 mL 0.6052 mL 1.2104 mL 2.4209 mL 3.0261 mL
    100 mM 0.0605 mL 0.3026 mL 0.6052 mL 1.2104 mL 1.513 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6-Angeloyloxyditropan-3-yl itaconate; 6-Angeloyloxyditropan-3-yl itaconate CFN00147 182015-05-0 C26H38N2O6 = 474.60 5mg QQ客服：2159513211
    2-苯甲酰基-3-羟基去甲莨菪烷; 2-Benzoyloxy-3-hydroxynortropane CFN00153 34622-25-8 C14H17NO3 = 247.29 5mg QQ客服：215959384
    2,3-Dihydrobellendine; 2,3-Dihydrobellendine CFN00178 72362-47-1 C12H17NO2 = 207.27 5mg QQ客服：2159513211
    Alkaloid C; Alkaloid C CFN00179 50656-88-7 C22H25NO3 = 351.44 5mg QQ客服：1413575084
    生物碱 KD1; Alkaloid KD1 CFN00180 50656-87-6 C17H23NO2 = 273.37 5mg QQ客服：1457312923
    Ferrugine; Ferrugine CFN00193 58471-11-7 C15H19NO = 229.32 5mg QQ客服：1413575084
    Ferruginine; Ferruginine CFN00194 73069-63-3 C10H15NO = 165.23 5mg QQ客服：2159513211
    Knightolamine; Knightolamine CFN00195 75638-70-9 C22H25NO4 = 367.44 5mg QQ客服：2056216494
    Isobellendine; Isobellendine CFN00199 72362-45-9 C12H15NO2 = 205.26 5mg QQ客服：1457312923

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