| In vivo: |
| Asia Pacif. J. Pharmacol.,1990,v.5:213-8. | | Vasorelaxation of Rat Aorta by Fargesone B Isolated from the Flower buds of Magnolia Fargesii[Reference: WebLink] | The effect of Fargesone B, isolated from Magnolia fargesii, on the contraction of rat aorta was studied.
METHODS AND RESULTS:
Fargesone B suppressed the contraction of aortic rings caused by cumulative concentrations of calcium (0.03-3 mM) in high potassium (60 mM) medium, with an IC50 of 12 .mu.g ml-1. It also relaxed the norepinephrine (NE, 3 .mu.M)-induced contraction, and its pretreatment inhibited both the phasic and tonic contractions elicited by NE, with an IC50 of about 100 and 30 .mu.g ml-1, respectively. This inhibition was also observed in the absence of calcium in the medium. It did not inhibit caffeine-induced phasic contraction. In quin-2-loaded cultured vascular smooth muscle cells, Fargesone B suppressed the rise of intracellular calcium caused by NE but not that by caffeine. 45Ca++ uptake by NE was also concentration-dependently inhibited by Fargesone B. Fargesone B did not change the levels of PGI2, cGMP or cAMP of rat aorta.
CONCLUSIONS:
It is concluded that Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium influxes in a nonselective |
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