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  • 宽缨酮

    Eurycomanone

    宽缨酮
    产品编号 CFN92008
    CAS编号 84633-29-4
    分子式 = 分子量 C20H24O9 = 408.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The roots of Eurycoma longifolia.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    宽缨酮 CFN92008 84633-29-4 10mg QQ客服:2159513211
    宽缨酮 CFN92008 84633-29-4 20mg QQ客服:2159513211
    宽缨酮 CFN92008 84633-29-4 50mg QQ客服:2159513211
    宽缨酮 CFN92008 84633-29-4 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Vigo (Spain)
  • Mahidol University (Thailand)
  • University of Bordeaux (France)
  • Yale University (USA)
  • St. Jude Children Research Hospital (USA)
  • Kamphaengphet Rajabhat University (Thailand)
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  • Universiti Malaysia Pahang (Malaysia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules 2021, 26(4),1092.
  • J Nat Med.2020, 74(1):65-75
  • Pharmaceutics.2021, 13(7):1028.
  • Molecules2022, 27(9):2613.
  • Foods.2022, 11(12):1708.
  • Antioxidants (Basel).2022, 11(1):171.
  • The Catharanthus Genome2022,35-83.
  • Environ Toxicol.2021, doi: 10.1002
  • Braz J Med Biol Res. 2016, 49(7)
  • Spectrochim Acta A2019, 210:372-380
  • J Food Biochem.2019, 43(9):e12970
  • Journal of Food Hygiene and Safety2019, 34(5):413-420
  • J Ginseng Res.2020, 44(4):611-618.
  • Int J Mol Sci.2021, 22(19):10220.
  • Tokyo Pharmaceutical University2020, 500001431953.
  • Chemistry of Natural Compounds2018, 54(3):572-576
  • BMC Complement Altern Med.2019, 19(1):11
  • Appl. Sci.2020, 10(20),7374.
  • Universitat Stuttgart2022, opus-12200.
  • J Ethnopharmacol.2022, 282:114574.
  • Pharmacol Rep.2020, 72(2):472-480.
  • Asian J Beauty Cosmetol2019, 17(3):287-294
  • Curr Res Virol Sci.2022, 3:100019.
  • ...
  • 生物活性
    Description: Eurycomanone has anti-cancer activity, it is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.
    Targets: NF-kB | IkB | P450 (e.g. CYP17) | p53 | Bcl-2/Bax | Caspase | IKK
    In vitro:
    Molecules. 2014 Sep 16;19(9):14649-66.
    Eurycomanone and eurycomanol from Eurycoma longifolia Jack as regulators of signaling pathways involved in proliferation, cell death and inflammation.[Pubmed: 25230121]
    Eurycomanone and eurycomanol are two quassinoids from the roots of Eurycoma longifolia Jack.
    METHODS AND RESULTS:
    The aim of this study was to assess the bioactivity of these compounds in Jurkat and K562 human leukemia cell models compared to peripheral blood mononuclear cells from healthy donors. Both eurycomanone and eurycomanol inhibited Jurkat and K562 cell viability and proliferation without affecting healthy cells. Interestingly, eurycomanone inhibited NF-κB signaling through inhibition of IκBα phosphorylation and upstream mitogen activated protein kinase (MAPK) signaling, but not eurycomanol.
    CONCLUSIONS:
    In conclusion, both quassinoids present differential toxicity towards leukemia cells, and the presence of the α,β-unsaturated ketone in eurycomanone could be prerequisite for the NF-κB inhibition.
    Phytomedicine. 2012 Jan 15;19(2):138-44.
    Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28.[Pubmed: 21903368]
    Bioactive compounds from the medicinal plant, Eurycoma longifolia Jack have been shown to promote anti-proliferative effects on various cancer cell lines.
    METHODS AND RESULTS:
    Here we examined the effects of purified eurycomanone, a quassinoid found in Eurycoma longifolia Jack extract, on the expression of selected genes of the A549 lung cancer cells. Eurycomanone inhibited A549 lung cancer cell proliferation in a dose-dependent manner at concentrations ranging from 5 to 20 μg/ml. The concentration that inhibited 50% of cell growth (GI(50)) was 5.1 μg/ml. The anti-proliferative effects were not fully reversible following the removal of eurycomanone, in which 30% of cell inhibition still remained (p<0.0001, T-test). At 8 μg/ml (GI(70)), eurycomanone suppressed anchorage-independent growth of A549 cells by >25% (p<0.05, T-test, n=8) as determined using soft agar colony formation assay. Cisplatin, a chemotherapy drug used for the treatment of non small cell lung cancer on the other hand, inhibited A549 cells proliferation at concentrations ranging from 0.2 μg/ml to 15 μg/ml with a GI(50) of 0.58 μg/ml. The treatment with eurycomanone reduced the abundance expression of the lung cancer markers, heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1, p53 tumor suppressor protein and other cancer-associated genes including prohibitin (PHB), annexin 1 (ANX1) and endoplasmic reticulum protein 28 (ERp28) but not the house keeping genes. The mRNA expressions of all genes with the exception of PHB were significantly downregulated, 72 h after treatment (p<0.05, T-test, n=9). These findings suggest that eurycomanone at viable therapeutic concentrations of 5-20 μg/ml exhibited significant anti-proliferative and anti-clonogenic cell growth effects on A549 lung cancer cells.
    CONCLUSIONS:
    The treatment also resulted in suppression of the lung cancer cell tumor markers and several known cancer cell growth-associated genes.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4486 mL 12.2429 mL 24.4858 mL 48.9716 mL 61.2145 mL
    5 mM 0.4897 mL 2.4486 mL 4.8972 mL 9.7943 mL 12.2429 mL
    10 mM 0.2449 mL 1.2243 mL 2.4486 mL 4.8972 mL 6.1214 mL
    50 mM 0.049 mL 0.2449 mL 0.4897 mL 0.9794 mL 1.2243 mL
    100 mM 0.0245 mL 0.1224 mL 0.2449 mL 0.4897 mL 0.6121 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    13,18-二氢乐园树酮; 13,18-Dehydroglaucarubinone CFN92980 68703-94-6 C25H32O10 = 492.52 5mg QQ客服:2159513211
    (+)-乐园树酮; (+)-Glaucarubinone CFN92979 1259-86-5 C25H34O10 = 494.53 5mg QQ客服:1457312923
    鸦胆子素B; Bruceine B CFN89335 25514-29-8 C23H28O11 = 480.46 5mg QQ客服:2056216494
    鸦胆子素C; Bruceine C CFN91974 25514-30-1 C28H36O12 = 564.58 5mg QQ客服:215959384
    鸦胆醇; Bruceantinol CFN89336 53729-52-5 C30H38O13 = 606.62 5mg QQ客服:2056216494
    鸦胆亭醇B; Bruceantinol B CFN95216 1822332-33-1 C27H34O12 = 550.6 5mg QQ客服:3257982914
    鸦胆亭醇; Bruceantinol A CFN91971 948038-36-6 C29H36O13 = 592.59 5mg QQ客服:2056216494
    鸦胆子素J; Bruceine J CFN91973 948038-38-8 C25H32O11 = 508.51 5mg QQ客服:3257982914
    鸦胆子素A; Bruceine A CFN89338 25514-31-2 C26H34O11 = 522.54 5mg QQ客服:1457312923
    鸦胆子苦醇; Brusatol CFN93119 14907-98-3 C26H32O11 = 520.53 20mg QQ客服:2159513211

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