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  • 过氧麦角甾醇 3-O-beta-D-吡喃葡萄糖苷

    Ergosterol peroxide glucoside

    过氧麦角甾醇 3-O-beta-D-吡喃葡萄糖苷
    产品编号 CFN99458
    CAS编号 140447-22-9
    分子式 = 分子量 C34H54O8 = 590.8
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The mushroom of Lactarius volemus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    过氧麦角甾醇 3-O-beta-D-吡喃葡萄糖苷 CFN99458 140447-22-9 1mg QQ客服:3257982914
    过氧麦角甾醇 3-O-beta-D-吡喃葡萄糖苷 CFN99458 140447-22-9 5mg QQ客服:3257982914
    过氧麦角甾醇 3-O-beta-D-吡喃葡萄糖苷 CFN99458 140447-22-9 10mg QQ客服:3257982914
    过氧麦角甾醇 3-O-beta-D-吡喃葡萄糖苷 CFN99458 140447-22-9 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2021, 26(3):695.
  • Bio-protocol2018, 9(14):e3301
  • International J of Green Pharmacy2019, 13(3)
  • Chin Med.2022, 17(1):66.
  • Molecules.2019, 24(21):E3834
  • Front Pharmacol.2021, 12:762829.
  • Int J Oncol.2019, 55(1):320-330
  • Nat Prod Commun.2017, 12(5):771-778
  • Planta Med.2018, 84(6-07):465-474
  • Exp Neurobiol.2018, 27(3):200-209
  • Int J Biol Macromol.2020, 161:1230-1239.
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • Asian Journal of Chemistry2014, 26(22):7811-7816
  • Current Traditional Medicine, 2021, 7:326-335(10).
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • Sci Rep. 2018, 1-9
  • Pharmaceuticals (Basel).2021, 14(10):1046.
  • Biochem Biophys Res Commun.2021, 534:802-807.
  • PLoS One.2021, 16(9):e0257243.
  • J Hematol Oncol.2018, 11(1):112
  • J Agric Food Chem.2018, 66(1):351-358
  • Drug Dev Res.2020, doi: 10.1002
  • PLoS One.2017, 12(3):e0173585
  • ...
  • 生物活性
    Description: Ergosterol peroxide exhibits anti-cancer, amoebicidal, anticomplementary, antibacterial, antiviral, anti-oxdiant, and anti-melanogenic activities. Ergosterol peroxide could as an anti-atherosclerosis agent, it exhibits hACAT-1 and Lp-PLA2 inhibitory effects, with inhibitory values of 51.6 +/- 0.9 and 51.7 +/- 1.2%, at a treatment concentration of 0.23 mM. Ergosterol peroxide has osteoclastogenesis inhibitory effect, it shows an inhibitory effect in a dose-dependent manner and an inhibition rate of up to 62% with low cytotoxicity, even at a concentration as low as 1.0 microg/mL.
    Targets: hACAT-1 | Lp-PLA2
    In vitro:
    Int. J. Med. Mushrooms, 2009, 11(3):249-57.
    Ergosterol Peroxide and 9,11-Dehydroergosterol Peroxide from Ling Zhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) Mycelia Inhibit the Growth of Human Breast Adenocarcinoma MCF-7 Cells[Reference: WebLink]

    METHODS AND RESULTS:
    Two fungal steroids, namely, ergosterol peroxide (EP) and (9,11-dehydroergosterol peroxide (9(11)-DHEP), were isolated and identified from the mycelia of Ling Zhi or Reishi medicinal mushroom, Ganoderma lucidum, grown under submerged culture. Both EP and 9(11)-DHEP exhibited inhibitory effects on human breast adenocarcinoma MCF-7 cells. The nontumorigenic human breast MCF-10-2A cells were less susceptible to these two compounds.
    CONCLUSIONS:
    Flow cytometric analyses suggested that these two fungal steroids inhibited the growth of MCF-7 cells by inducing cell apoptosis.
    Arch Pharm Res. 2005 May;28(5):541-5.
    Ergosterol peroxide from flowers of Erigeron annuus L. as an anti-atherosclerosis agent.[Pubmed: 15974439]

    METHODS AND RESULTS:
    Flowers of Erigeron annuus L. were extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH, and H2O. Repeated silica gel and ODS column chromatography of the EtOAc fraction led to the isolation of a sterol, through activity-guided fractionation, using ACAT inhibitory activity measurements. From the physico-chemical data, including NMR, MS, and IR, the chemical structure of the compound was determined to be an ergosterol peroxide (1), which has been isolated for the first time from this plant.
    CONCLUSIONS:
    This compound exhibited hACAT-1 and Lp-PLA2 inhibitory effects, with inhibitory values of 51.6 +/- 0.9 and 51.7 +/- 1.2%, at a treatment concentration of 0.23 mM.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6926 mL 8.4631 mL 16.9262 mL 33.8524 mL 42.3155 mL
    5 mM 0.3385 mL 1.6926 mL 3.3852 mL 6.7705 mL 8.4631 mL
    10 mM 0.1693 mL 0.8463 mL 1.6926 mL 3.3852 mL 4.2316 mL
    50 mM 0.0339 mL 0.1693 mL 0.3385 mL 0.677 mL 0.8463 mL
    100 mM 0.0169 mL 0.0846 mL 0.1693 mL 0.3385 mL 0.4232 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    菜油甾醇; Campesterol CFN92204 474-62-4 C28H48O = 400.7 10mg QQ客服:2159513211
    菜籽甾醇; Brassicasterol CFN90471 474-67-9 C28H46O = 398.66 5mg QQ客服:1413575084
    星鱼甾醇; Stellasterol CFN98267 2465-11-4 C28H46O = 398.7 5mg QQ客服:1413575084
    麦角甾-7,22-二烯-3-酮; Ergosta-7,22-dien-3-one CFN96785 32507-77-0 C28H44O = 396.65 5mg QQ客服:1413575084
    麦角固醇; 麦角甾醇; Ergosterol CFN98980 57-87-4 C28H44O = 396.7 20mg QQ客服:2159513211
    麦角甾醇葡萄糖苷; Ergosterol glucoside CFN89026 130155-33-8 C34H54O6 = 558.8 5mg QQ客服:1413575084
    麦角甾-5,24(28)-二烯-3,7,16-三醇; Ergosta-5,24(28)-diene-3,7,16-triol CFN98357 289054-34-8 C28H46O3 = 430.7 5mg QQ客服:2932563308
    3Beta-羟基麦角甾-5-烯-7-酮; 3-beta-Hydroxyergost-5-en-7-one CFN99665 156767-69-0 C28H46O2 = 414.7 5mg QQ客服:3257982914
    麦角甾-4,6,8(14),22-四烯-3-酮; Ergosta-4,6,8(14),22-tetraen-3-one CFN99889 19254-69-4 C28H40O = 392.6 5mg QQ客服:3257982914
    啤酒甾醇; Cerevisterol CFN98825 516-37-0 C28H46O3 = 430.7 5mg QQ客服:2159513211

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