Info: Read More
  • 中药标准品生产商,产品定制服务
  • 表没食子儿茶素3-O-(3''-O-甲基)没食子酸酯

    (-)-Epigallocatechin-3-(3''-O-methyl) gallate

    表没食子儿茶素3-O-(3''-O-甲基)没食子酸酯
    产品编号 CFN92081
    CAS编号 83104-87-4
    分子式 = 分子量 C23H20O11 = 472.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The leaves of Camellia sinensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    表没食子儿茶素3-O-(3''-O-甲基)没食子酸酯 CFN92081 83104-87-4 1mg QQ客服:2056216494
    表没食子儿茶素3-O-(3''-O-甲基)没食子酸酯 CFN92081 83104-87-4 5mg QQ客服:2056216494
    表没食子儿茶素3-O-(3''-O-甲基)没食子酸酯 CFN92081 83104-87-4 10mg QQ客服:2056216494
    表没食子儿茶素3-O-(3''-O-甲基)没食子酸酯 CFN92081 83104-87-4 20mg QQ客服:2056216494
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Complutense University of Madrid (Spain)
  • University of Lodz (Poland)
  • Imperial College London (United Kingdom)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Universidade do Porto (Portugal)
  • The Australian National University (Australia)
  • Chungnam National University (Korea)
  • Celltrion Chemical Research Institute (Korea)
  • Ateneo de Manila University (Philippines)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Pennsylvania State University (USA)
  • Kitasato University (Japan)
  • Universidade Federal de Santa Catarina (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Chem.2019, 290:286-294
  • Sci Rep.2018, 8:15059
  • J Nat Sc Biol Med2019, 10(2):149-156
  • University of Limpopo2016, 1-237
  • Regul Toxicol Pharmacol.2023, 142:105433.
  • J Med Food.2019, 22(10):1067-1077
  • Ann Transl Med.2019, 7(23):731
  • J Ethnopharmacol.2022, 282:114574.
  • Food Sci Nutr.2023, 11(9):5532-5542.
  • Mol Cells.2018, 41(8):771-780
  • Front Cell Dev Biol.2020, 8:32.
  • LWT2021, 138:110397.
  • Int J Mol Sci.2021, 22(21):11447.
  • Biochemistry.2018, 57(40):5886-5896
  • Molecules2022, 27(12):3903.
  • Biomedicines.2020, 8(11):486.
  • Nutraceuticals2022, 2(3),150-161
  • Front Pharmacol.2021, 12:744624.
  • Research on Crops.2017, 18(3):569
  • Foods.2022, 11(12):1773.
  • Phytother Res.2016, 30(12):2020-2026
  • J of Food Quality2020, 8851285.
  • Saudi Pharmaceutical Journal2023, 31(12):101829
  • ...
  • 生物活性
    Description: (-)-Epigallocatechin-3-(3''-O-methyl)gallate shows antioxidative, cytotoxic, antiallergic, and anti-inflammatory activities, it can negatively regulate basophil activation through the suppression of FcepsilonRI expression. Epigallocatechin-3-(3''-O-methyl)gallate has the function for cold preservation of primary rat hepatocytes.
    Targets: Immunology & Inflammation related
    In vitro:
    Agr. Biol. Chem., 2000, 64(10):2218-20.
    Antioxidative activity of (-)-epigallocatechin-3-(3''-O-methyl)gallate isolated from fresh tea leaf and preliminary results on its biological activity.[Pubmed: 11129598 ]
    Antioxidative activity of (-)-Epigallocatechin-3-(3''-O-methyl) gallate (catechine) was examined.
    METHODS AND RESULTS:
    Catechine showed a strong antioxidative activity. A preliminary test using rat cancer cells suggests that catechin e also has a strong cytotoxic activity. Among tested catechins, only catechin e has strong activity for both.
    J. Agr. Food Chem., 2002, 50(20):5729-34.
    Antiallergic tea catechin, (-)-epigallocatechin-3-O-(3-O-methyl)-gallate, suppresses FcepsilonRI expression in human basophilic KU812 cells.[Pubmed: 12236706]
    We previously found that the O-methylated derivative of (-)-Epigallocatechin-3-O-gallate (EGCg), (-)-epigallocatechin-3-O-(3-O-methyl)-gallate (EGCG' '3Me), has potent antiallergic activity.
    METHODS AND RESULTS:
    The high-affinity IgE receptor, FcepsilonRI, is found at high levels on basophils and mast cells and plays a key role in a series of acute and chronic human allergic reactions. To understand the mechanism of action for the antiallergic EGCG' '3Me, the effect of EGCG' '3Me on the cell surface expression of FcepsilonRI in human basophilic KU812 cells was examined. Flow cytometric analysis showed that EGCG' '3Me was able to decrease the cell surface expression of FcepsilonRI. Moreover, immunoblot analysis revealed that total cellular expression of the FcepsilonRI alpha chain decreased upon treatment with EGCG' '3Me. FcepsilonRI is a tetrameric structure comprising one alpha chain, one beta chain, and two gamma chains. The level of mRNA production of each subunit in KU812 cells was investigated. EGCG' '3Me reduced FcepsilonRI alpha and gamma mRNA levels. The cross-linkage of FcepsilonRI causes the activation of basophils, which leads to the secretion of inflammatory mediators including histamine. EGCG' '3Me treatment inhibited the FcepsilonRI cross-linking-induced histamine release.
    CONCLUSIONS:
    These results suggested that EGCG' '3Me can negatively regulate basophil activation through the suppression of FcepsilonRI expression.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1169 mL 10.5843 mL 21.1685 mL 42.337 mL 52.9213 mL
    5 mM 0.4234 mL 2.1169 mL 4.2337 mL 8.4674 mL 10.5843 mL
    10 mM 0.2117 mL 1.0584 mL 2.1169 mL 4.2337 mL 5.2921 mL
    50 mM 0.0423 mL 0.2117 mL 0.4234 mL 0.8467 mL 1.0584 mL
    100 mM 0.0212 mL 0.1058 mL 0.2117 mL 0.4234 mL 0.5292 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    表儿茶素没食子酸酯; (-)-Epicatechin gallate CFN99570 1257-08-5 C22H18O10 = 442.38 20mg QQ客服:1457312923
    表儿茶素3-O-(3''-O-甲基)没食子酸酯; (-)-Epicatechin-3-(3''-O-methyl) gallate CFN92080 83104-86-3 C23H20O10 = 456.4 5mg QQ客服:2159513211
    (-)-表没食子儿茶素; (-)-Epigallocatechin(EGC) CFN97549 970-74-1 C15H14O7 = 306.3 20mg QQ客服:1413575084
    (-)-表没食子儿茶素没食子酸酯; (-)-Epigallocatechin gallate CFN99569 989-51-5 C22H18O11 = 458.38 20mg QQ客服:1413575084
    乙酰化表没食子儿茶素没食子酸酯; Epigallocatechin gallate octaacetate CFN91644 148707-39-5 C38H34O19 = 794.7 5mg QQ客服:1413575084
    表没食子儿茶素3-O-(3''-O-甲基)没食子酸酯; (-)-Epigallocatechin-3-(3''-O-methyl) gallate CFN92081 83104-87-4 C23H20O11 = 472.4 10mg QQ客服:2056216494
    (-)-表阿夫儿茶精; (-)-Epiafzelechin CFN98271 24808-04-6 C15H14O5 = 274.3 10mg QQ客服:2159513211
    3-羟基-4',5,7-三甲氧基黄烷; 3-Hydroxy-4',5,7-trimethoxyflavan CFN95680 3143-21-3 C18H20O5 = 316.4 5mg QQ客服:2159513211
    3,3'-二羟基-4',5,7-三甲氧基黄烷; 3,3'-Dihydroxy-4',5,7-trimethoxyflavan CFN95679 97914-22-2 C18H20O6 = 332.4 5mg QQ客服:2159513211
    3,4'-二羟基-3',5,7-三甲氧基黄烷; 3,4'-Dihydroxy-3,5',7-trimethoxyflavan CFN97558 97914-19-7 C18H20O6 = 332.4 5mg QQ客服:1457312923

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产