延命草素

Enmein

	产品编号	CFN92435
	CAS编号	3776-39-4
	分子式 = 分子量	C₂₀H₂₆O₆ = 362.4
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The herbs of Isodon japonicus
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
延命草素	CFN92435	3776-39-4	1mg	QQ客服：2159513211
延命草素	CFN92435	3776-39-4	5mg	QQ客服：2159513211
延命草素	CFN92435	3776-39-4	10mg	QQ客服：2159513211
延命草素	CFN92435	3776-39-4	20mg	QQ客服：2159513211

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Description:

Enmein shows significant inhibitory effect toward human tumor cell K562 with IC(50) values ranging from 3.2 microg/ml to 8.2 microg/ml, it shows antitumour activity against Ehrlich ascites carcinoma and is active against gram-positive bacteria. Enmein has distinct immunosuppressive effect in vitro and in vivo systems, it depresses the murine ear swelling extent and the level of Interleukin-2 in blood serum in a dose-dependent manner.

Targets:

Immunology & Inflammation related | Antifection

In vitro:

Planta Med. 2002 Oct;68(10):921-5.

Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata.[Pubmed: 12391557]

METHODS AND RESULTS:
Four new ent-kaurane diterpenoids, sculponeatins F-I (1-4), together with six known compounds, sculponeatin E (5), epi-nodosin (6), epi-nodosinol (7), Enmein (8), and macrocalyxoformins A and B (9 and 10), were isolated from the leaves of Isodon sculponeata. Also obtained were ursolic acid, 2alpha,3beta-dihydroxy-urs-12-en-28-oic acid, 2alpha,3beta,19alpha-trihydroxy-urs-12-en-28-oic acid, beta-sitosterol, daucosterol, quercetin, pedalitin, rosmarinic acid, caffeic acid and ethyl caffeic acid. Their structures were determined by spectral methods (1D-, 2D-NMR and MS). Some diterpenoids were tested for their cytotoxicity to inhibit three kinds of human tumor cells K562, A549 and T24.
CONCLUSIONS:
Compounds 3, 4, 6, 8, and 10 showed significant inhibitory effect toward K562 with IC(50) values ranging from 3.2 microg/ml to 8.2 microg/ml, while 3 and 6 exhibited potent antitumor activity against T24, but none exhibited cytotoxicity toward the cells of A549.

In vivo:

Int Immunopharmacol. 2005 Dec;5(13-14):1957-65.

Distinct immunosuppressive effect by Isodon serra extracts.[Pubmed: 16275630 ]

Distinct effect of ent-Kaurene Diterpenoids from Isodon serra on abnormal proliferation of murine lymphocytes was examined with MTT assay and Flow Cytometry Analyses (FCAS).
METHODS AND RESULTS:
After choosing the most appropriate monomer from these Diterpenoids, we introduced mouse tumescence model to investigate whether it could impact cytokine production in vivo with ELISA assay. The result of MTT assay showed that four ent-Kaurene Diterpenoids could effectively suppress the murine splenic T lymphocytes overproduction stimulated by Concanavalin A, while inhibitive effect was softer on normal sleep lymphocytes than the stimulated ones. Among four ent-Kaurene Diterpenoids, Enmein was the most sensitive one with IC50/EC50 equaling to 1.55. This inhibitive activity was due to interfering DNA replication in G1-S stage and to regulating cell cycle according to flow cytometry analyses (FCAS) result. Xylene-induced mouse tumescence model result further suggested that Enmein depressed the murine ear swelling extent and the level of Interleukin-2 in blood serum in a dose-dependent manner.
CONCLUSIONS:
In conclusion, it demonstrated that four ent-Kaurene Diterpenoids from I. serra had distinct immunosuppressive effect in vitro and in vivo systems, which primarily differentiated Enmein from the others. The experimental results provided insight into a potential immunosuppressive action of Enmein as a promising drug, though profound mechanism remained to be further studied.

Chem Pharm Bull (Tokyo). 1976 Sep;24(9):2118-27.

The Antitumor and Antibacterial Activity of the Isodon Diterpenoids[Reference: WebLink]

METHODS AND RESULTS:
Oridonin (1), lasiokaurin (2), Enmein (8), and Enmein-3-acetate (9) and related compounds (3 and 10,) all of which have α-methylene cyclopentanone function in their molecule, have been shown to have antitumor activity against Ehrlich ascites carcinoma inoculated into mice. These compounds have also indicated specific activity against gram-positive bacteria. On the other hand, oridonin dihydro-derivative (4), compound (5), trichokaurin (6), and dihydroEnmein (11) show any activity against neither tumor nor bacteria.
CONCLUSIONS:
Thus, it is concluded that the α-methylene-cyclopentanone system must be an important active center. Biomimetic reactions of oridonin and Enmein with several thiols etc. support this conclusion.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7594 mL	13.7969 mL	27.5938 mL	55.1876 mL	68.9845 mL
5 mM	0.5519 mL	2.7594 mL	5.5188 mL	11.0375 mL	13.7969 mL
10 mM	0.2759 mL	1.3797 mL	2.7594 mL	5.5188 mL	6.8985 mL
50 mM	0.0552 mL	0.2759 mL	0.5519 mL	1.1038 mL	1.3797 mL
100 mM	0.0276 mL	0.138 mL	0.2759 mL	0.5519 mL	0.6898 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
(-)-Isodocarpin; (-)-Isodocarpin	CFN92313	10391-08-9	C₂₀H₂₆O₅ = 346.4	5mg	QQ客服：215959384
延命草素; Enmein	CFN92435	3776-39-4	C₂₀H₂₆O₆ = 362.4	5mg	QQ客服：1457312923
表诺多星; Epinodosin	CFN92315	20086-60-6	C₂₀H₂₆O₆ = 362.4	5mg	QQ客服：215959384
诺多星; Nodosin	CFN99056	10391-09-0	C₂₀H₂₆O₆ = 362.4	5mg	QQ客服：1413575084
黄花香茶菜素A; Sculponeatin A	CFN97414	85287-60-1	C₂₀H₂₄O₆ = 360.4	5mg	QQ客服：3257982914
13-脱氧-10-O-乙基-8-羟基延命素; Serrin A	CFN96677	845959-98-0	C₂₂H₃₀O₆ = 390.47	5mg	QQ客服：2159513211
Carpalasionin; Carpalasionin	CFN89366	83150-97-4	C₂₂H₂₈O₈ = 420.45	5mg	QQ客服：2159513211

延命草素

Enmein

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