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  • 延命草素

    Enmein

    延命草素
    产品编号 CFN92435
    CAS编号 3776-39-4
    分子式 = 分子量 C20H26O6 = 362.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The herbs of Isodon japonicus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    延命草素 CFN92435 3776-39-4 1mg QQ客服:3257982914
    延命草素 CFN92435 3776-39-4 5mg QQ客服:3257982914
    延命草素 CFN92435 3776-39-4 10mg QQ客服:3257982914
    延命草素 CFN92435 3776-39-4 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Zurich (Switzerland)
  • Florida A&M University (USA)
  • Macau University of Science and Technology (China)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • University of Ioannina (Greece)
  • Sant Gadge Baba Amravati University (India)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Donald Danforth Plant Science Center (USA)
  • Imperial College London (United Kingdom)
  • National Research Council of Canada (Canada)
  • University of Vigo (Spain)
  • Julius Kühn-Institut (Germany)
  • National Chung Hsing University (Taiwan)
  • Shanghai University of TCM (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Foods.2022, 11(12):1773.
  • Int J Mol Sci. 2014, 15(5):8443-57
  • J Phys Chem Lett.2021, 12(7):1793-1802.
  • J Colloid Interface Sci.2022, 622:298-308.
  • Anal Bioanal Chem.2018, 410(5):1561-1569
  • Toxicol Res.2019, 35(4):371-387
  • Cancers (Basel).2021, 13(6):1432.
  • Nutrients.2017, 10(1)
  • Integr Cancer Ther.2018, 17(3):832-843
  • Biomed Pharmacother.2020, 131:110673.
  • Phytother Res.2019, 33(5):1490-1500
  • Front Pharmacol.2021, 12:615157.
  • BMC Complement Med Ther. 2020, 20(1):91.
  • Molecules.2021, 26(3):695.
  • Molecules.2016, 21(6)
  • Environ Toxicol.2020, doi: 10.1002
  • Phytomedicine.2021, 93:153796.
  • Hindawi J of Food Biochemistry2023, P17:8883860
  • Phytomedicine.2019, 62:152962
  • Biomedicine & Pharmacotherapy2022, 153:113404.
  • Molecules.2019, 24(11):E2102
  • LWT2021, 138:110630.
  • J Cell Biochem.2022, 123(7):1222-1236.
  • ...
  • 生物活性
    Description: Enmein shows significant inhibitory effect toward human tumor cell K562 with IC(50) values ranging from 3.2 microg/ml to 8.2 microg/ml, it shows antitumour activity against Ehrlich ascites carcinoma and is active against gram-positive bacteria. Enmein has distinct immunosuppressive effect in vitro and in vivo systems, it depresses the murine ear swelling extent and the level of Interleukin-2 in blood serum in a dose-dependent manner.
    Targets: Immunology & Inflammation related | Antifection
    In vitro:
    Planta Med. 2002 Oct;68(10):921-5.
    Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata.[Pubmed: 12391557]

    METHODS AND RESULTS:
    Four new ent-kaurane diterpenoids, sculponeatins F-I (1-4), together with six known compounds, sculponeatin E (5), epi-nodosin (6), epi-nodosinol (7), Enmein (8), and macrocalyxoformins A and B (9 and 10), were isolated from the leaves of Isodon sculponeata. Also obtained were ursolic acid, 2alpha,3beta-dihydroxy-urs-12-en-28-oic acid, 2alpha,3beta,19alpha-trihydroxy-urs-12-en-28-oic acid, beta-sitosterol, daucosterol, quercetin, pedalitin, rosmarinic acid, caffeic acid and ethyl caffeic acid. Their structures were determined by spectral methods (1D-, 2D-NMR and MS). Some diterpenoids were tested for their cytotoxicity to inhibit three kinds of human tumor cells K562, A549 and T24.
    CONCLUSIONS:
    Compounds 3, 4, 6, 8, and 10 showed significant inhibitory effect toward K562 with IC(50) values ranging from 3.2 microg/ml to 8.2 microg/ml, while 3 and 6 exhibited potent antitumor activity against T24, but none exhibited cytotoxicity toward the cells of A549.
    In vivo:
    Int Immunopharmacol. 2005 Dec;5(13-14):1957-65.
    Distinct immunosuppressive effect by Isodon serra extracts.[Pubmed: 16275630 ]
    Distinct effect of ent-Kaurene Diterpenoids from Isodon serra on abnormal proliferation of murine lymphocytes was examined with MTT assay and Flow Cytometry Analyses (FCAS).
    METHODS AND RESULTS:
    After choosing the most appropriate monomer from these Diterpenoids, we introduced mouse tumescence model to investigate whether it could impact cytokine production in vivo with ELISA assay. The result of MTT assay showed that four ent-Kaurene Diterpenoids could effectively suppress the murine splenic T lymphocytes overproduction stimulated by Concanavalin A, while inhibitive effect was softer on normal sleep lymphocytes than the stimulated ones. Among four ent-Kaurene Diterpenoids, Enmein was the most sensitive one with IC50/EC50 equaling to 1.55. This inhibitive activity was due to interfering DNA replication in G1-S stage and to regulating cell cycle according to flow cytometry analyses (FCAS) result. Xylene-induced mouse tumescence model result further suggested that Enmein depressed the murine ear swelling extent and the level of Interleukin-2 in blood serum in a dose-dependent manner.
    CONCLUSIONS:
    In conclusion, it demonstrated that four ent-Kaurene Diterpenoids from I. serra had distinct immunosuppressive effect in vitro and in vivo systems, which primarily differentiated Enmein from the others. The experimental results provided insight into a potential immunosuppressive action of Enmein as a promising drug, though profound mechanism remained to be further studied.
    Chem Pharm Bull (Tokyo). 1976 Sep;24(9):2118-27.
    The Antitumor and Antibacterial Activity of the Isodon Diterpenoids[Reference: WebLink]

    METHODS AND RESULTS:
    Oridonin (1), lasiokaurin (2), Enmein (8), and Enmein-3-acetate (9) and related compounds (3 and 10,) all of which have α-methylene cyclopentanone function in their molecule, have been shown to have antitumor activity against Ehrlich ascites carcinoma inoculated into mice. These compounds have also indicated specific activity against gram-positive bacteria. On the other hand, oridonin dihydro-derivative (4), compound (5), trichokaurin (6), and dihydroEnmein (11) show any activity against neither tumor nor bacteria.
    CONCLUSIONS:
    Thus, it is concluded that the α-methylene-cyclopentanone system must be an important active center. Biomimetic reactions of oridonin and Enmein with several thiols etc. support this conclusion.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7594 mL 13.7969 mL 27.5938 mL 55.1876 mL 68.9845 mL
    5 mM 0.5519 mL 2.7594 mL 5.5188 mL 11.0375 mL 13.7969 mL
    10 mM 0.2759 mL 1.3797 mL 2.7594 mL 5.5188 mL 6.8985 mL
    50 mM 0.0552 mL 0.2759 mL 0.5519 mL 1.1038 mL 1.3797 mL
    100 mM 0.0276 mL 0.138 mL 0.2759 mL 0.5519 mL 0.6898 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (-)-Isodocarpin; (-)-Isodocarpin CFN92313 10391-08-9 C20H26O5 = 346.4 5mg QQ客服:2056216494
    延命草素; Enmein CFN92435 3776-39-4 C20H26O6 = 362.4 5mg QQ客服:2056216494
    表诺多星; Epinodosin CFN92315 20086-60-6 C20H26O6 = 362.4 5mg QQ客服:1457312923
    诺多星; Nodosin CFN99056 10391-09-0 C20H26O6 = 362.4 5mg QQ客服:3257982914
    黄花香茶菜素A; Sculponeatin A CFN97414 85287-60-1 C20H24O6 = 360.4 5mg QQ客服:215959384
    13-脱氧-10-O-乙基-8-羟基延命素; Serrin A CFN96677 845959-98-0 C22H30O6 = 390.47 5mg QQ客服:1413575084
    Carpalasionin; Carpalasionin CFN89366 83150-97-4 C22H28O8 = 420.45 5mg QQ客服:2056216494

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