齿孔酸; 齿孔菌酸

Eburicoic acid

	产品编号	CFN90414
	CAS编号	560-66-7
	分子式 = 分子量	C₃₁H₅₀O₃ = 470.73
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The roots of Wolfiporia cocos (Schw.) Ryv.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
齿孔酸; 齿孔菌酸	CFN90414	560-66-7	1mg	QQ客服：1413575084
齿孔酸; 齿孔菌酸	CFN90414	560-66-7	5mg	QQ客服：1413575084
齿孔酸; 齿孔菌酸	CFN90414	560-66-7	10mg	QQ客服：1413575084
齿孔酸; 齿孔菌酸	CFN90414	560-66-7	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Srinakharinwirot University (Thailand)

Universidad de Ciencias y Artes de Chiapas (Mexico)

Universidade Federal de Goias (UFG) (Brazil)

University of South Australia (Australia)

Guangzhou Institutes of Biomedicine and Health (China)

Stanford University (USA)

University of Dicle (Turkey)

Istanbul University (Turkey)

National Research Council of Canada (Canada)

Universidad Veracuzana (Mexico)

University of Fribourg (Switzerland)

Colorado State University (USA)

University of Vigo (Spain)

University of Sao Paulo (Brazil)

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Description:

Eburicoic acid and TR2 have anti-inflammatory activity, the mechanism is related to the decrease of inflammatory cytokines and an increase of antioxidant enzyme activity, they protect the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms. Eburicoic acid has significant anti-liver cancer effects and more distinctive mechanisms.

Targets:

SOD | NO | TNF-α | NOS | COX | P450 (e.g. CYP17) | IL Receptor

In vivo:

J Agric Food Chem. 2013 May 29;61(21):5064-71.

Analgesic and anti-inflammatory bioactivities of eburicoic acid and dehydroeburicoic acid isolated from Antrodia camphorata on the inflammatory mediator expression in mice.[Pubmed: 23495748 ]

Eburicoic acid (TR1) and dehydroEburicoic acid (TR2), an active ingredient from Antrodia camphorata (AC) solid-state culture, were evaluated for analgesic and anti-inflammatory effects.
METHODS AND RESULTS:
Treatment with Eburicoic acid and TR2 significantly inhibited a number of acetic acid-induced writhing responses and formalin-induced pain in the late phase. In the anti-inflammatory test, Eburicoic acid and TR2 decreased paw edema at the fourth and fifth hour after λ-carrageenan (Carr) administration and increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the paw edema tissue. We also demonstrated that Eburicoic acid and TR2 significantly attenuated the malondialdehyde (MDA), nitric oxide (NO), tumor necrosis factor (TNF-α), and interleukin-1β (IL-1β) levels in either edema paw or serum at the fifth hour after Carr injection. Western blotting revealed that Eburicoic acid and TR2 decreased Carr-induced inducible nitric oxide synthase (iNOS) and cycloxyclase (COX-2) expressions at the fifth hour in paw edema. Treatment with TR1 and TR2 also diminished neutrophil infiltration into the paw edema at the fifth hour.
CONCLUSIONS:
The present study suggests that the anti-inflammatory mechanisms of Eburicoic acid and TR2 might be related to the decrease of inflammatory cytokines and an increase of antioxidant enzyme activity.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
齿孔酸; 齿孔菌酸; Eburicoic acid	CFN90414	560-66-7	C₃₁H₅₀O₃ = 470.73	10mg	QQ客服：215959384
土莫酸; Tumulosic acid	CFN95399	508-24-7	C₃₁H₅₀O₄ = 486.7	5mg	QQ客服：215959384
茯苓酸；茯灵酸; Pachymic acid	CFN99590	29070-92-6	C₃₃H₅₂O₅ = 528.76	20mg	QQ客服：2056216494
二氢齿孔酸; Dehydroeburicoic acid	CFN92740	6879-05-6	C₃₁H₄₈O₃ = 468.7	5mg	QQ客服：1457312923
去氢土莫酸; Dehydrotumulosic acid	CFN92837	6754-16-1	C₃₁H₄₈O₄ = 484.7	10mg	QQ客服：2159513211
去氢茯苓酸; Dehydropachymic acid	CFN92742	77012-31-8	C₃₃H₅₀O₅ = 526.8	10mg	QQ客服：1457312923
3-表去氢土莫酸; 3-Epidehydrotumulosic acid	CFN92743	167775-54-4	C₃₁H₄₈O₄ = 484.7	5mg	QQ客服：1413575084
3-表去氢茯苓酸; 3-Epidehydropachymic acid	CFN92738	168293-15-0	C₃₃H₅₀O₅ = 526.8	5mg	QQ客服：215959384
6alpha-羟基去氢茯苓酸; 6alpha-Hydroxydehydropachymic acid	CFN95412	176390-67-3	C₃₃H₅₀O₆ = 542.8	5mg	QQ客服：2159513211
过氧去氢土莫酸; Peroxydehydrotumulosic acid	CFN92836	943225-53-4	C₃₁H₄₆O₆ = 514.7	5mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1244 mL	10.6218 mL	21.2436 mL	42.4872 mL	53.109 mL
5 mM	0.4249 mL	2.1244 mL	4.2487 mL	8.4974 mL	10.6218 mL
10 mM	0.2124 mL	1.0622 mL	2.1244 mL	4.2487 mL	5.3109 mL
50 mM	0.0425 mL	0.2124 mL	0.4249 mL	0.8497 mL	1.0622 mL
100 mM	0.0212 mL	0.1062 mL	0.2124 mL	0.4249 mL	0.5311 mL