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    Dehydropachymic acid

    去氢茯苓酸
    产品编号 CFN92742
    CAS编号 77012-31-8
    分子式 = 分子量 C33H50O5 = 526.8
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Wolfiporia cocos (Schw.) Ryv.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    去氢茯苓酸 CFN92742 77012-31-8 1mg QQ客服:3257982914
    去氢茯苓酸 CFN92742 77012-31-8 5mg QQ客服:3257982914
    去氢茯苓酸 CFN92742 77012-31-8 10mg QQ客服:3257982914
    去氢茯苓酸 CFN92742 77012-31-8 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Aveiro University (Portugal)
  • FORTH-IMBB (Greece)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Ateneo de Manila University (Philippines)
  • Donald Danforth Plant Science Center (USA)
  • University of Canterbury (New Zealand)
  • Griffith University (Australia)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • University of Dicle (Turkey)
  • Heidelberg University (Germany)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Monash University (Australia)
  • University of Madras (India)
  • Sanford Burnham Medical Research Institute (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Immunol.2017, 8:1542
  • Molecules. 2013, 18(11):14105-21
  • The Korea Journal of Herbology2016, 29-35
  • Front Neurosci.2019, 13:1091
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • bioRxiv - Molecular Biology2023, 535548.
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • J Pharm Biomed Anal.2021, 196:113931.
  • Sci Rep.2019, 9(1):18080
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • BMC Complement Altern Med.2014, 14:352
  • J Appl Biol Chem.2022, 65(4):pp.463-469.
  • Molecules.2021, 26(6):1635.
  • Molecules.2018, 23(12):E3103
  • GENENCELL2023, 25:4356740
  • Cancer Sci.2022, 113(4):1406-1416.
  • Food and Fermentation Industries2018, 44(371)
  • Horticulturae2022, 8(10), 975.
  • J Sep Sci.2020, 43(22):4148-4161.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • Research Square2021, 10.21203.
  • Sci Rep.2017, 7:46299
  • ...
  • 生物活性
    Description: Dehydropachymic acid shows antiinflammatory activity.
    Targets: Immunology & Inflammation related
    In vitro:
    Int J Oncol. 2013 Jun;42(6):1869-74.
    Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7.[Pubmed: 23588713]
    Poria cocos is a medicinal mushroom that is widely used in traditional Asian medicine.
    METHODS AND RESULTS:
    Here, we show that a characterized mixture of triterpenes extracted from P. cocos (PTE) and three purified triterpenes: pachymic acid (PA), dehydropachymic acid (DPA) and polyporenic acid C (PPAC) suppress the proliferation of the human pancreatic cancer cell lines Panc-1, MiaPaca-2, AsPc-1 and BxPc-3. Moreover, the most effective compound, PA, only slightly affects the proliferation of HPDE-6 normal pancreatic duct epithelial cells. The anti-proliferative effects of PTE on BxPc-3 cells are mediated by the cell cycle arrest at G0/G1 phase. DNA microarray analysis demonstrated that PTE significantly downregulates the expression of KRAS and matrix metalloproteinase-7 (MMP-7) in BxPc-3 cells. In addition, PTE and PA suppress the invasive behavior of BxPc-3 cells. The inhibition of invasiveness by PTE and PA was associated with the reduction of MMP-7 at the protein level and the role of MMP-7 further confirmed by the gene silencing of MMP-7 which also suppressed the invasiveness of BxPc-3 cells.
    CONCLUSIONS:
    In conclusion, triterpenes from P. cocos demonstrate anticancer and anti-invasive effects on human pancreatic cancer cells and can be considered as new therapeutic agents in the treatment of pancreatic cancer.
    In vivo:
    J Ethnopharmacol . 2017 Feb 23;198:167-173.
    Dehydropachymic acid decreases bafilomycin A1 induced β-Amyloid accumulation in PC12 cells[Pubmed: 28077330]
    Abstract Ethnopharmacological relevance: Fuling, the sclerotium of Poria cocos, was frequently used in traditional Chinese medicine (TCM) formulae for Alzheimer's disease (AD) intervention over the past 10 centuries. And its extracts exhibited significant effects in both cellular and animal models of AD in previous studies. However, its mechanisms on prevention and treatment of AD have not been well elucidated yet. Aim of the study: To investigate the effect and corresponding mechanisms of dehydropachymic acid, which is one of the major triterpenes in P. cocos, on the clearance of β-amyloid accumulation in bafilomycin A1 induced PC12 cells. Materials and methods: MTT assay was used to examine the DPA effect on the viability of PC12 cells stable transfected with pCB6-APP (PC12-APP). PC12-APP cells were treated with DPA at the concentration of 6.25, 12.5, 25μg/mL for 4h, and then co-treated with 50nmol/L bafilomycin A1 for 48h except the controls. The Aβ1-42 content in culture medium was determined by ELISA. The intracellular amount of APP, Aβ1-42, LC3, cathepsin D was measured by Western blotting and normalized to GAPDH loading control. The PC12 cells stable transfected with pSelect-LC3-GFP (PC12-LC3-GFP) was used in the fluorescence microscopy estimation of autophagosomes accumulation. The internal pH in lysosome was detected by LysoTracker Red staining. Results: DPA had no significant effect on the cell viability but could significantly decrease Aβ1-42 content in culture medium and eliminate the intracellular accumulation of APP and Aβ1-42 in bafilomycin A1 induced PC12-APP cells. Furthermore, DPA lowered the LC3-II/LC3-I ratio and reduced the GFP-labeled LC3 puncta which were elevated by bafilomycin A1. And the increase in internal pH of lysosome and decrease in mCatD amount in Bafilomycin A1 induced PC12-APP cells were restored by DPA treatment. These results indicated that DPA could restore the lysosomal acidification and recover the autophgic flux which is impaired by bafilomycin A1. Conclusions: DPA could effectively clear the accumulation of Aβ1-42 in bafilomycin A1 impaired PC12 cells through restoring the lysosomal acidification and recovering the autophgic flux. And these results highlight its therapeutic potential for AD treatment. Keywords: Alzheimer's disease; Autophagy; Bafilomycin A1; Bafilomycin A1 (PubChem CID: 6436223); Dehydropachymic acid; Dehydropachymic acid (PubChem CID: 15226717); Lysosome; β-amyloid.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8983 mL 9.4913 mL 18.9825 mL 37.9651 mL 47.4563 mL
    5 mM 0.3797 mL 1.8983 mL 3.7965 mL 7.593 mL 9.4913 mL
    10 mM 0.1898 mL 0.9491 mL 1.8983 mL 3.7965 mL 4.7456 mL
    50 mM 0.038 mL 0.1898 mL 0.3797 mL 0.7593 mL 0.9491 mL
    100 mM 0.019 mL 0.0949 mL 0.1898 mL 0.3797 mL 0.4746 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    多孔菌酸C; Polyporenic acid C CFN92739 465-18-9 C31H46O4 = 482.7 10mg QQ客服:2159513211
    16-O-Acetylpolyporenic acid C; 16-O-Acetylpolyporenic acid C CFN96159 2535-06-0 C33H48O5 = 524.7 5mg QQ客服:215959384
    6α-羟基猪苓酸C; 6alpha-Hydroxypolyporenic acid C CFN92741 24513-63-1 C31H46O5 = 498.7 5mg QQ客服:2159513211
    新化合物15; New compound 15 CFN95413 N/A C31H46O6 = 514.7 5mg QQ客服:1413575084
    茯苓新酸A; Poricoic acid A(F) CFN92838 137551-38-3 C31H46O5 = 498.7 20mg QQ客服:1457312923
    茯苓酸AM; Poricoic acid AM CFN91538 151200-92-9 C32H48O5 = 512.7 5mg QQ客服:1413575084
    Poricoic acid AE ; Poricoic acid AE CFN96980 1159753-88-4 C33H50O5 = 526.75 5mg QQ客服:3257982914
    24(31)-Dehydrocarboxyacetylquercinic acid; 24(31)-Dehydrocarboxyacetylquercinic acid CFN96179 127970-62-1 C34H50O7 = 570.8 5mg QQ客服:215959384
    齿孔酸; 齿孔菌酸; Eburicoic acid CFN90414 560-66-7 C31H50O3 = 470.73 10mg QQ客服:3257982914
    土莫酸; Tumulosic acid CFN95399 508-24-7 C31H50O4 = 486.7 5mg QQ客服:3257982914

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