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  • 二氢异丹参酮I

    • 二氢异丹参酮I

    Dihydroisotanshinone I

    二氢异丹参酮I
    		产品编号 CFN90162
    CAS编号 20958-18-3
    分子式 = 分子量 C18H14O3 = 278.30
    产品纯度 >=98%
    物理属性 Red powder
    化合物类型 Diterpenoids
    植物来源 The roots of Salvia miltiorrhiza Bge.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    二氢异丹参酮I CFN90162 20958-18-3 1mg QQ客服：2159513211
    二氢异丹参酮I CFN90162 20958-18-3 5mg QQ客服：2159513211
    二氢异丹参酮I CFN90162 20958-18-3 10mg QQ客服：2159513211
    二氢异丹参酮I CFN90162 20958-18-3 20mg QQ客服：2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Phytother Res.2020, 34(4):788-795.
  • Plants (Basel).2021, 10(11):2317.
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  • J Biomed Sci.2020, 27(1):60.
  • J Ethnopharmacol.2023, 317:116789.
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  • ...
    • 生物活性
    Description: Dihydroisotanshinone I has protective action against menadione-induced hepatotoxicity, attributed to its antioxidant properties including the free radical scavenging activity and inhibition of lipid peroxidation.
    Targets: Calcium Channel | ATPase | Potassium Channel
    In vitro:
    Planta Med. 2002 Dec;68(12):1077-81.
    Dihydroisotanshinone I protects against menadione-induced toxicity in a primary culture of rat hepatocytes.[Pubmed: 12494333]
    Dihydroisotanshinone I is a phenanthrenequinone derivative isolated from the roots of Salvia trijuga Diels.
    METHODS AND RESULTS:
    The present study demonstrated the hepatoprotective effect of Dihydroisotanshinone I against menadione-induced cytotoxicity in a primary culture of rat hepatocytes. Pretreating the cells with Dihydroisotanshinone I at concentrations ranging from 2.5 microM to 20 microM for 24 hours caused dose-dependent protection against hepatotoxicity induced by menadione. Intracellular glutathione level and activity of DT-diaphorase have been suggested to play important roles in menadione-induced cytotoxicity. However, treating the hepatocytes with 20 microM Dihydroisotanshinone I for 24 hours did not cause a significant change in glutathione level and DT-diaphorase activity. On the contrary, adding Dihydroisotanshinone I to freshly isolated hepatocytes at concentrations between 50 nM to 200 nM inhibited NADH-induced superoxide production dose-dependently as indicated by the decrease of lucigenin-amplified chemiluminescence. In addition, Dihydroisotanshinone I at concentrations ranging from 5 microM to 20 microM inhibited tert-butyl hydroperoxide-induced lipid peroxidation dose-dependently in isolated hepatocytes as indicated by the level of malondialdehyde.
    CONCLUSIONS:
    These results suggest that the protective action of Dihydroisotanshinone I against menadione-induced hepatotoxicity is attributed to its antioxidant properties including the free radical scavenging activity and inhibition of lipid peroxidation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5932 mL 17.9662 mL 35.9324 mL 71.8649 mL 89.8311 mL
    5 mM 0.7186 mL 3.5932 mL 7.1865 mL 14.373 mL 17.9662 mL
    10 mM 0.3593 mL 1.7966 mL 3.5932 mL 7.1865 mL 8.9831 mL
    50 mM 0.0719 mL 0.3593 mL 0.7186 mL 1.4373 mL 1.7966 mL
    100 mM 0.0359 mL 0.1797 mL 0.3593 mL 0.7186 mL 0.8983 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    丹参新醌C; Danshenxinkun C CFN90327 65907-77-9 C16H12O3 = 252.3 5mg QQ客服：215959384
    丹参新醌B; Danshenxinkun B CFN90326 65907-76-8 C18H16O3 = 280.3 5mg QQ客服：2159513211
    丹参新醌A; Danshenxinkun A CFN90325 65907-75-7 C18H16O4 = 296.32 5mg QQ客服：2056216494
    丹参新醌D; Danshenxinkun D CFN90328 98873-76-8 C21H20O4 = 336.38 5mg QQ客服：3257982914
    二氢异丹参酮I; Dihydroisotanshinone I CFN90162 20958-18-3 C18H14O3 = 278.30 10mg QQ客服：215959384
    异隐丹参酮; Isocryptotanshinone CFN90355 22550-15-8 C19H20O3 = 296.36 5mg QQ客服：1413575084
    异丹参酮I; Isotanshinone I CFN90356 20958-17-2 C18H12O3 = 276.29 5mg QQ客服：2056216494
    异丹参酮IIA; Isotanshinone IIA CFN90357 20958-15-0 C19H18O3 = 294.35 5mg QQ客服：1413575084

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