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  • 二氢菜豆酸

    Dihydrophaseic acid

    二氢菜豆酸
    产品编号 CFN98657
    CAS编号 41756-77-8
    分子式 = 分子量 C15H22O5 = 282.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Echinocystis macrocarpa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    二氢菜豆酸 CFN98657 41756-77-8 1mg QQ客服:1413575084
    二氢菜豆酸 CFN98657 41756-77-8 5mg QQ客服:1413575084
    二氢菜豆酸 CFN98657 41756-77-8 10mg QQ客服:1413575084
    二氢菜豆酸 CFN98657 41756-77-8 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Regional Crop Research Institute (Korea)
  • Stanford University (USA)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • University of Lodz (Poland)
  • University of Wisconsin-Madison (USA)
  • Wageningen University (Netherlands)
  • Sapienza University of Rome (Italy)
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  • Guangzhou Institutes of Biomedicine and Health (China)
  • Shanghai Institute of Organic Chemistry (China)
  • University of Perugia (Italy)
  • Uniwersytet Gdański (Poland)
  • Kamphaengphet Rajabhat University (Thailand)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nutrients.2021, 13(1):254.
  • Daru.2022, 30(2):273-288.
  • Molecules.2022, 27(7):2093.
  • Int J Mol Sci.2018, 19(2)
  • Asian J Beauty Cosmetol2019, 17(3):287-294
  • JABS2020, 14:2(2020)
  • Journal of Apicultural Research2021, 60(1)
  • Appl. Sci.2021, 11(24),12080
  • J Adv Res.2019, 17:85-94
  • Phytomedicine.2018, 41:62-66
  • Int J Food Sci Nutr.2019, 70(7):825-833
  • JOTCSA.2023, 10(4); 893-902.
  • Sci Rep.2015, 5:13194
  • Evid Based Complement Alternat Med.2021, 2021:8847358.
  • Agronomy2023, 13(6), 1435.
  • LWT2021, 138:110630.
  • Eur J Pharmacol.2018, 832:96-103
  • Korea Institute of Oriental Medicine2020, doi: 10.21203.
  • Food Funct.2022, doi: 10.1039
  • Pak J Pharm Sci.2023, 36(1):51-57.
  • Analytical Letters 2021, 54(4).
  • Sci Rep.2021, 11(1):21038.
  • Front Pharmacol.2021, 12:770667.
  • ...
  • 生物活性
    Description: Dihydrophaseic acid 3’-O-b-D-glucopyranoside (D3G) can increase the proliferation and differentiation of osteoblast cells and enhance bone formation, suggests that D3G may be a good candidate for the treatment of osteoporosis.
    In vitro:
    Osteoporosis and Sarcopenia 2015,1(2):137-8.
    Antiosteoporotic Activity of Dihydrophaseic Acid 3′-O-b-D-Glucopyranoside Derivatives from Lycii Radicis Cortex.[Reference: WebLink]
    Our previous study demonstrated that ethanol extract of Lycii Radicis Cortex (LRC) prevented the ovariectomized-induced bone mineral density loss in mice via promoting the differentiation of osteoblast linage cells. A single compound, D3G, was isolated from the LRC extract as a candidate component enhancing bone formation. The aim of this study was to investigate the antiosteoporotic effects of Dihydrophaseic acid 3ʹ-O-b-D-glucopyranoside (D3G).
    METHODS AND RESULTS:
    The highest alkaline phosphatase activity was observed with 5 μg/ml of D3G in both cell lines: C3H10T1/2 and MC3T3-E1. The D3G treatment for 21 days increased the mineralized nodule formation in the MC3T3-E1 cell line. The expression of osteoblastic markers, Alpl, Runx2, and Bglap, was significantly increased in the D3G-treated cells compared to the non-treated control cells. The D3G treatment did not influence osteoclast differentiation in primary-cultured monocytes of mouse bone marrow. In coculture of monocytes and MC3T3-E1 cells, however, D3G induced both osteoblast and osteoclast differentiation.
    CONCLUSIONS:
    This study demonstrated that D3G increased the proliferation and differentiation of osteoblast cells and enhanced bone formation. These results suggest that D3G may be a good candidate for the treatment of osteoporosis
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5423 mL 17.7117 mL 35.4233 mL 70.8466 mL 88.5583 mL
    5 mM 0.7085 mL 3.5423 mL 7.0847 mL 14.1693 mL 17.7117 mL
    10 mM 0.3542 mL 1.7712 mL 3.5423 mL 7.0847 mL 8.8558 mL
    50 mM 0.0708 mL 0.3542 mL 0.7085 mL 1.4169 mL 1.7712 mL
    100 mM 0.0354 mL 0.1771 mL 0.3542 mL 0.7085 mL 0.8856 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Breyniaionoside A; Breyniaionoside A CFN96810 823182-23-6 C19H32O9 = 404.45 5mg QQ客服:3257982914
    Cucumegastigmane I; Cucumegastigmane I CFN97498 929881-46-9 C13H20O4 = 240.3 5mg QQ客服:2159513211
    罗布麻酚A; Apocynol A CFN97750 358721-33-2 C13H20O3 = 224.30 5mg QQ客服:1413575084
    7-巨豆烯-3,5,6,9-四醇; Megastigm-7-ene-3,5,6,9-tetraol CFN98335 680617-50-9 C13H24O4 = 244.3 5mg QQ客服:1413575084
    7-巨豆烯-3,5,6,9-四醇; 7-Megastigmene-3,5,6,9-tetraol CFN98334 276870-26-9 C13H24O4 = 244.3 5mg QQ客服:2056216494
    野鸦椿素B; Euscaphin B CFN97536 956869-95-7 C14H26O4 = 258.4 5mg QQ客服:2159513211
    Megastigm-7-ene-3,4,6,9-tetrol; Megastigm-7-ene-3,4,6,9-tetrol CFN96244 180164-14-1 C13H24O4 = 244.3 5mg QQ客服:215959384
    (3E)-4-[(3R,4S)-3,4-二羟基-2,6,6-三甲基-1-环己烯-1-基]-3-丁烯-2-酮; cis-3,4-Dihydroxy-beta-ionone CFN96404 875666-39-0 C13H20O3 = 224.3 5mg QQ客服:2159513211
    Ascleposide E; Ascleposide E CFN98414 325686-49-5 C19H32O8 = 388.5 5mg QQ客服:215959384
    Citroside A ; Citroside A CFN96992 120330-44-1 C19H30O8 = 386.44 5mg QQ客服:1413575084

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