二氢醉椒素
Dihydrokavain
|
|
产品编号 |
CFN90536 |
| CAS编号 |
587-63-3 |
| 分子式 = 分子量 |
C14H16O3 = 232.27 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Phenols |
| 植物来源 |
The roots of Piper methysticum Forst. |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 二氢醉椒素 |
CFN90536 |
587-63-3 |
10mg |
QQ客服：3004468087 |
| 二氢醉椒素 |
CFN90536 |
587-63-3 |
20mg |
QQ客服：3004468087 |
| 二氢醉椒素 |
CFN90536 |
587-63-3 |
50mg |
QQ客服：3004468087 |
| 二氢醉椒素 |
CFN90536 |
587-63-3 |
100mg |
QQ客服：3004468087 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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Agricultural Research Organization (ARO) (Israel)
Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
Universidade da Beira Interior (Germany)
National Hellenic Research Foundation (Greece)
Sapienza University of Rome (Italy)
University of Virginia (USA)
Technical University of Denmark (Denmark)
Mendel University in Brno (Czech Republic)
University of Queensland (Australia)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
Food Sci Nutr.2019, 8(1):246-256
Int J Mol Sci.2017, 18(12)
J Agric Food Chem.2017, 65(13):2670-2676
ACS Pharmacol. Transl. Sci.2022, 5,7,479-490
J Pharmaceut Biomed2020, 182:113110
J Ginseng Res.2023, 47(4):572-582.
Molecules.2021, 26(2):E255.
Korean Journal of Pharmacognosy2017, 48(4):320-328
| Description: |
Dihydrokavain may play an important role in regulation of GABAergic neurotransmission, it non-competitively inhibits the specific binding of [3H]-batrachotoxinin-A 20-alpha-benzoate to receptor site 2 of voltage-gated Na+ channels. Dihydrokavain may treat sleep disturbances, as well as stress and anxiety.
|
| Targets: |
GABA Receptor | Sodium channel |
| In vitro: |
| Planta Med. 2002 Dec;68(12):1092-6. | | Kavalactones and dihydrokavain modulate GABAergic activity in a rat gastric-brainstem preparation.[Pubmed: 12494336] |
METHODS AND RESULTS:
Using an in vitro neonatal rat gastric-brainstem preparation, the activity of majority neurons recorded in the nucleus tractus solitarius (NTS) of the brainstem were significantly inhibited by GABA A receptor agonist, muscimol (30 microM), and this inhibition was reversed by selective GABA A receptor antagonist, bicuculline (10 microM). Application of kavalactones (300 microg/ml) and dihydrokavain (300 microM) into the brainstem compartment of the preparation also significantly reduced the discharge rate of these NTS neurons (39 % and 32 %, respectively, compared to the control level), and this reduction was partially reversed by bicuculline (10 microM). Kavalactones or dihydrokavain induced inhibitory effects were not reduced after co-application of saclofen (10 microM; a selective GABA B receptor antagonist) or naloxone (100 nM; an opioid receptor antagonist). Pretreatment with kavalactones (300 microg/ml) or dihydrokavain (300 microM) significantly decreased the NTS inhibitory effects induced by muscimol (30 microM), approximately from 51 % to 36 %.
CONCLUSIONS:
Our results demonstrated modulation of brainstem GABAergic mechanism by kavalactones and dihydrokavain, and suggested that these compounds may play an important role in regulation of GABAergic neurotransmission. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
4.3053 mL |
21.5267 mL |
43.0533 mL |
86.1067 mL |
107.6334 mL |
| 5 mM |
0.8611 mL |
4.3053 mL |
8.6107 mL |
17.2213 mL |
21.5267 mL |
| 10 mM |
0.4305 mL |
2.1527 mL |
4.3053 mL |
8.6107 mL |
10.7633 mL |
| 50 mM |
0.0861 mL |
0.4305 mL |
0.8611 mL |
1.7221 mL |
2.1527 mL |
| 100 mM |
0.0431 mL |
0.2153 mL |
0.4305 mL |
0.8611 mL |
1.0763 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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