| In vitro: |
| Journal of shenyang pharmaceutical university, 2008, 25(1):24-29. | | Phenylpropanoids compounds isolated from Drynaria fortunei and their proliferation effects on UMR 106 cell.[Reference: WebLink] | To study the phenylpropanoid constituents from Drynaria fortunei and the effects of isolated compounds on the proliferation of the rat osteoblastic UMR 106 cells.
METHODS AND RESULTS:
The constituents in the 60% ethanol extract of Drynaria fortunei were isolated by a combination of silica gel,Sephadex LH-20 and ODS chromatographies and their structures were identified by spectral methods.Their effects on the proliferation activities of UMR 106 cell were measured.Results Seven known phenylpropanoids and two benzoic acid derivatives were isolated from Drynaria fortunei.Their structures were identified by means of spectroscopic analysis as:(E)-caffeic acid 4-O-β-D-glucopyranoside(1),trans-p-(sinapoyl)-β-D-glucopyranoside(2),ferulic acid β-glucoside(3),trans-caffeic acid(4),p-coumaric acid 4-O-β-D-glucopyranoside(5),dihydroisoferulic acid(6),dihydrocaffeic acid(7),vanillic acid 4-O-β-D-glucoside(8),protocatechuic acid(9).Their effects on the proliferation activities of UMR 106 cell were measured.
CONCLUSIONS:
Compounds 2-8 are obtained from this genus for the first time,while compound 1 is firstly isolated from this species.The effects of compounds 1-9 are tested on UMR 106 cells,among them,1-4 increase the proliferation activities of UMR 106 cells. |
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