Dihydrobonducellin

	产品编号	CFN92828
	CAS编号	103680-87-1
	分子式 = 分子量	C₁₇H₁₆O₄ = 284.3
	产品纯度	>=98%
	物理属性	Cryst.
	化合物类型	Flavonoids
	植物来源	The herbs of Caesalpinia decapetala
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Dihydrobonducellin	CFN92828	103680-87-1	1mg	QQ客服：1457312923
Dihydrobonducellin	CFN92828	103680-87-1	5mg	QQ客服：1457312923
Dihydrobonducellin	CFN92828	103680-87-1	10mg	QQ客服：1457312923
Dihydrobonducellin	CFN92828	103680-87-1	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Wroclaw Medical University (Poland)

University of Fribourg (Switzerland)

Northeast Normal University Changchun (China)

Sant Gadge Baba Amravati University (India)

Universidade Federal de Santa Catarina (Brazil)

Aarhus University (Denmark)

Leibniz Institute of Plant Biochemistry (Germany)

Uniwersytet Medyczny w ?odzi (Poland)

Kazusa DNA Research Institute (Japan)

Medizinische Universit?t Wien (Austria)

University of Pretoria (South Africa)

Imperial College London (United Kingdom)

University of Toulouse (France)

University of Bordeaux (France)

More...

Description:

Dihydrobonducellin has immunopharmacological activity, it significantly inhibits the production of IL-2 and IFN-gamma in activated PBMC in a concentration-dependent manner.

Targets:

IL Receptor | IFN-γ

In vitro:

Molecules. 2009 May 12;14(5):1789-95.

Isolation and immunomodulatory effect of homoisoflavones and flavones from Agave sisalana Perrine ex Engelm.[Pubmed: 19471199]

METHODS AND RESULTS:
Three known flavones and seven known homoisoflavonoids were isolated from the methanolic extract of the leaves of Agave sisalanaPerrine ex Engelm. Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were also evaluated for immunopharmacological activity. PBMC were used as target cells, and cell proliferation was determined by (3)H-thymidine uptake. (+/-)-3,9-Dihydroeucomin (4), dihydrobonducellin (5), and 5,7-dihydroxy-3-(4'-hydroxybenzyl)-4-chromanone (7) showed inhibitory effects on PBMC proliferation activated by PHA with IC(50) values 19.4, 73.8, and 58.8 microM, respectively.
CONCLUSIONS:
All three compounds significantly inhibited the production of IL-2 and IFN-gamma in activated PBMC in a concentration-dependent manner.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
4H-1-Benzopyran-4-one,2,3-dihydro-5-hydroxy-3-[(4-hydroxyphenyl)methyl]-7-methoxy-; 4H-1-Benzopyran-4-one,2,3-dihydro-5-hydroxy-3-[(4-hydroxyphenyl)methyl]-7-methoxy-	CFN91144	108001-32-7	C₁₇H₁₆O₅ = 300.3	5mg	QQ客服：2159513211
Loureiriol; Loureiriol	CFN91153	479195-44-3	C₁₆H₁₄O₆ = 302.3	5mg	QQ客服：2159513211
Eucomol; Eucomol	CFN96506	17934-12-2	C₁₇H₁₆O₆ = 316.31	5mg	QQ客服：215959384
7-O-Methyleucomol; 7-O-Methyleucomol	CFN96517	17934-15-5	C₁₈H₁₈O₆ = 330.33	5mg	QQ客服：2056216494
3'-Hydroxy-3,9-dihydroeucomin; 3'-Hydroxy-3,9-dihydroeucomin	CFN99081	107585-75-1	C₁₇H₁₆O₆ = 316.3	5mg	QQ客服：215959384
8-O-Demethyl-7-O-methyl-3,9-dihydropunctatin; 8-O-Demethyl-7-O-methyl-3,9-dihydropunctatin	CFN97500	93078-83-2	C₁₇H₁₆O₆ = 316.3	5mg	QQ客服：2056216494
(3R)-5,7-Dihydroxy-6-methyl-3-(4'-hydroxybenzyl)chroman-4-one; (3R)-5,7-Dihydroxy-6-methyl-3-(4'-hydroxybenzyl)chroman-4-one	CFN91154	84638-48-2	C₁₇H₁₆O₅ = 300.3	5mg	QQ客服：2056216494
沿阶草酮 A; Ophiopogonanone A	CFN96337	75239-63-3	C₁₈H₁₆O₆ = 328.3	5mg	QQ客服：3257982914
3-(2,4-Dihydroxybenzyl)-5-hydroxy-7,8-dimethoxy-6-methylchroman-4-one; 3-(2,4-Dihydroxybenzyl)-5-hydroxy-7,8-dimethoxy-6-methylchroman-4-one	CFN96342	149180-48-3	C₁₉H₂₀O₇ = 360.4	5mg	QQ客服：2056216494
沿阶草酮 E; Ophiopogonanone E	CFN96332	588706-66-5	C₁₉H₂₀O₇ = 360.4	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5174 mL	17.5871 mL	35.1741 mL	70.3482 mL	87.9353 mL
5 mM	0.7035 mL	3.5174 mL	7.0348 mL	14.0696 mL	17.5871 mL
10 mM	0.3517 mL	1.7587 mL	3.5174 mL	7.0348 mL	8.7935 mL
50 mM	0.0703 mL	0.3517 mL	0.7035 mL	1.407 mL	1.7587 mL
100 mM	0.0352 mL	0.1759 mL	0.3517 mL	0.7035 mL	0.8794 mL