| In vitro: |
| J Nanosci Nanotechnol. 2014 Jul;14(7):5426-9. | | Diethanolamine-modified magnetic fluorescent Fe3O4@ZnS nanoparticles for ultrasensitive detection and removal of Cu2+.[Pubmed: 24758043] | Currently, growing attention has been paid to the sensitive determination and removal of Cu2+ because excessive levels of Cu2+ could do harm to organisms.
METHODS AND RESULTS:
Herein, a novel Diethanolamine-modified magnetic fluorescent Fe3O4@ZnS nanoparticle (MFNP) for simultaneous detection and removal of Cu2+ was designed and synthesized through dithiocarbamate linkage strategy. The characterization of MFNP was confirmed by transmission electron microscope (TEM), infrared (IR) and emission spectra.
CONCLUSIONS:
The results showed that MFNP could quantificationally detect Cu2+ with high sensitivity and selectivity under a broad pH range (pH 4.5-9). The removal of Cu2+ was achieved by the aggregation-induced sedimentation (AIS) strategy and by external magnetic field. | | Aquat Toxicol. 2010 Aug 15;99(2):212-22. | | Molecular effects of diethanolamine exposure on Calanus finmarchicus (Crustacea: Copepoda).[Pubmed: 20537412] | Of particular interest is the use of alkanolamines such as Diethanolamine (DEA) in the removal of CO(2) from natural gas and for CO(2) capture following fossil fuel combustion.In an attempt to assess the potential effects of alkanolamines in the marine environment, a key species in the North Atlantic, the planktonic copepod Calanus finmarchicus, was studied for molecular effects following sublethal exposure to Diethanolamine.
METHODS AND RESULTS:
Diethanolamine-induced alterations in transcriptome and metabolome profiling were assessed using a suppression subtractive hybridization (SSH) gene library method and high resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR), respectively. Together, SSH and HR-MAS NMR offer complementary screening tools for the assessment of molecular responses of C. finmarchicus to Diethanolamine and can be used in the study of other chemicals and organisms. Concentration-response and time-response relationships between Diethanolamine exposure and single gene transcription were investigated using quantitative PCR. Specific relationships were found between Diethanolamine exposure and the transcription of genes involved in protein catabolism (ubiquitin-specific protease-7), metal ion homeostasis (ferritin) and defence against oxidative stress (gamma-glutamylcysteine synthase, glutathione synthase and Cu/Zn-superoxide dismutase). Finally, similar transcription patterns were observed for a number of different genes following exposure to Diethanolamine, which indicates analogous mechanisms of toxicity and response. |
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