荷包牡丹碱

Dicentrine

	产品编号	CFN92331
	CAS编号	517-66-8
	分子式 = 分子量	C₂₀H₂₁NO₄ = 339.4
	产品纯度	>=98%
	物理属性	Cryst.
	化合物类型	Alkaloids
	植物来源	The roots of Stephania delavayi Diels
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
荷包牡丹碱	CFN92331	517-66-8	1mg	QQ客服：2056216494
荷包牡丹碱	CFN92331	517-66-8	5mg	QQ客服：2056216494
荷包牡丹碱	CFN92331	517-66-8	10mg	QQ客服：2056216494
荷包牡丹碱	CFN92331	517-66-8	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Dicentrine, a selective α(1)-adrenoceptor antagonist with potent antiarrhythmic and antihypertensive activities, it also has antinociception in different models of chemical pain. Dicentrine induces DNA lesions to arrest cell cycle. Callus and cell suspension cultures of S. venosa can produce high levels of Dicentrine as an alternative source of plant materials.

In vitro:

Nat Prod Commun. 2013 Apr;8(4):443-5.

Dicentrine production in callus and cell suspension cultures of Stephania venosa.[Pubmed: 23738448]

METHODS AND RESULTS:
The highest Dicentrine content (19.5 +/- 0.3 mg/g dry weight) from callus culture of Stephania venosa was achieved from stem segments cultured on MS medium supplemented with TDZ 0.5 mg/L and NAA 1.0 mg/L. Cell suspension cultures were established from callus cultured on MS liquid medium with the same plant growth regulators. Dicentrine production from S. venosa cell suspension cultures was obtained in the range of 15-26 mg/g dry weight. Elicitation in cell suspension cultures by chitosan (50 mg/L) and salicylic acid (2 mg/L) for 6 days significantly increased Dicentrine content.
CONCLUSIONS:
Our findings indicate that callus and cell suspension cultures of S. venosa can produce high levels of Dicentrine as an alternative source of plant materials.

In vivo:

Planta Med. 2012 Sep;78(14):1543-8. Epub 2012 Jul 16.

Antinociceptive effects of a chloroform extract and the alkaloid dicentrine isolated from fruits of Ocotea puberula.[Pubmed: 22815198]

The present work describes the chemical characterization of a chloroform fraction (CF) obtained from an extract of Ocotea puberula (Lauraceae) fruits, and preliminary antinociceptive analysis of CF and the alkaloid Dicentrine, isolated from this fraction.
METHODS AND RESULTS:
CF (30-300 mg/kg, p. o.) caused dose-related inhibition of abdominal constrictions caused by acetic acid and also inhibited both phases of formalin-induced nociception. Furthermore, Dicentrine (30-300 mg/kg, p. o.) produced dose-related inhibition of acetic acid-induced pain without causing changes in the motor performance of mice.
CONCLUSIONS:
The results show, for the first time, that CF from Ocotea puberula fruits produced marked antinociception in different models of chemical pain, and this effect appears to be, at least in part, due to the presence of Dicentrine. The mechanism by which CF and the alkaloid produced antinociception still remains unclear, but the adenosinergic or opioid system seems unlikely to be involved in this action.

Drug Metab Dispos. 2010 Oct;38(10):1714-22.

Metabolism of dicentrine: identification of the phase I and phase II metabolites in miniature pig urine.[Pubmed: 20622045]

METHODS AND RESULTS:
The metabolic profile of Dicentrine, a selective α(1)-adrenoceptor antagonist with potent antiarrhythmic and antihypertensive activities, in miniature pig urine via oral administration was investigated for the first time. The urine, collected after a single oral administration of Dicentrine, was pretreated using solvent extraction and column chromatographic methods to identify the metabolites containing fractions.
CONCLUSIONS:
The phase I metabolic transformations of Dicentrine were found to be N-demethylation, N-oxidation, O-demethylation (9,10-OMe), O,O-demethylenation (1-OCH(2)O-2), and hydroxylation at the benzylic (C-4) and the aromatic (C-3) positions, whereas those for the phase II were O-glucuronidation and O-glucosylation of the phenolic group of the phase I metabolites.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
N-去甲基荷叶碱; 原荷叶碱; N-Nornuciferine	CFN96149	4846-19-9	C₁₈H₁₉NO₂ = 281.4	20mg	QQ客服：2159513211
北美鹅掌楸尼定碱; Lirinidine	CFN91037	54383-28-7	C₁₈H₁₉NO₂ = 281.4	10mg	QQ客服：2159513211
去氢海罂粟碱; Dehydroglaucine	CFN90406	22212-26-6	C₂₁H₂₃NO₄ = 353.41	5mg	QQ客服：1457312923
去氢克班宁; Dehydrocrebanine	CFN97265	77784-22-6	C₂₀H₁₉NO₄ = 337.4	5mg	QQ客服：2056216494
N-甲基瓜馥木碱甲; N-Methylcalycinine	CFN97425	86537-66-8	C₁₉H₁₉NO₄ = 325.4	5mg	QQ客服：1413575084
荷包牡丹碱; Dicentrine	CFN92331	517-66-8	C₂₀H₂₁NO₄ = 339.4	5mg	QQ客服：2159513211
克班宁; Crebanine	CFN98275	25127-29-1	C₂₀H₂₁NO₄ = 339.4	20mg	QQ客服：1457312923
千金藤碱; Stephanine	CFN98828	517-63-5	C₁₉H₁₉NO₃ = 309.4	5mg	QQ客服：1413575084
O-去甲基荷叶碱 ; O-Nornuciferine	CFN96770	3153-55-7	C₁₈H₁₉NO₂ = 281.35	5mg	QQ客服：2159513211
荷叶碱; Nuciferine	CFN99733	475-83-2	C₁₉H₂₁NO₂ = 295.38	20mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9464 mL	14.7319 mL	29.4638 mL	58.9275 mL	73.6594 mL
5 mM	0.5893 mL	2.9464 mL	5.8928 mL	11.7855 mL	14.7319 mL
10 mM	0.2946 mL	1.4732 mL	2.9464 mL	5.8928 mL	7.3659 mL
50 mM	0.0589 mL	0.2946 mL	0.5893 mL	1.1786 mL	1.4732 mL
100 mM	0.0295 mL	0.1473 mL	0.2946 mL	0.5893 mL	0.7366 mL

荷包牡丹碱

Dicentrine

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