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  • 去甲氧基去乙酰氧基土槿甲酸B

    Demethoxydeacetoxypseudolaric acid B

    去甲氧基去乙酰氧基土槿甲酸B
    产品编号 CFN97312
    CAS编号 82508-36-9
    分子式 = 分子量 C20H24O7 = 376.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The root barks of Pseudolarix amabilis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    去甲氧基去乙酰氧基土槿甲酸B CFN97312 82508-36-9 1mg QQ客服:3257982914
    去甲氧基去乙酰氧基土槿甲酸B CFN97312 82508-36-9 5mg QQ客服:3257982914
    去甲氧基去乙酰氧基土槿甲酸B CFN97312 82508-36-9 10mg QQ客服:3257982914
    去甲氧基去乙酰氧基土槿甲酸B CFN97312 82508-36-9 20mg QQ客服:3257982914
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
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    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
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    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
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  • ...
  • 生物活性
    Description: Demethoxydeacetoxypseudolaric acid B's the metabolic reaction of TDA in vivo is mainly occurred in blood and contributes to be the hydrolysis of plasma esterase to ester bond, as well as the glucosylation reaction.
    In vivo:
    Yao Xue Xue Bao. 2014 Aug;49(8):1169-74.
    Metabolic pathway and metabolites of total diterpene acid isolated from Pseudolarix kaempferi.[Pubmed: 25322560]
    The preliminary metabolic profile of total diterpene acid (TDA) isolated from Pseudolarix kaempferi was investigated by using in vivo and in vitro tests.
    METHODS AND RESULTS:
    Pseudolaric acid C2 (PC2) was identified as the predominant metabolite in plasma, urine, bile and feces after both oral and intravenous administrations to rats using HPLC-UV and HPLC-ESI/MS(n), and Demethoxydeacetoxypseudolaric acid B (DDPB), a metabolite proposed to be the glucoside of PC2 (PC2G), as well as pseudolaric acid C (PC), pseudolaric acid A (PA), pseudolaric acid A O-beta-D glucopyranoside (PAG), pseudolaric acid B O-beta-D glucopyranoside (PBG) and deacetylpseudolaric acid A (DPA) originated from TDA could also be detected. It was demonstrated by tests that the metabolism of TDA is independent of intestinal microflora, and neither of pepsin and trypsin is in charge of metabolism of TDA, TDA is also stable in both pH environments of gastric tract and intestinal tract.
    CONCLUSIONS:
    The metabolites of TDA in whole blood in vitro incubation were found to be PC2, Demethoxydeacetoxypseudolaric acid B and PC2G, which demonstrated that the metabolic reaction of TDA in vivo is mainly occurred in blood and contributed to be the hydrolysis of plasma esterase to ester bond, as well as the glucosylation reaction. These results clarified the metabolic pathway of TDA for the first time, which is of great significance to the in vivo active form and acting mechanism research of P. kaempferi.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6567 mL 13.2837 mL 26.5675 mL 53.135 mL 66.4187 mL
    5 mM 0.5313 mL 2.6567 mL 5.3135 mL 10.627 mL 13.2837 mL
    10 mM 0.2657 mL 1.3284 mL 2.6567 mL 5.3135 mL 6.6419 mL
    50 mM 0.0531 mL 0.2657 mL 0.5313 mL 1.0627 mL 1.3284 mL
    100 mM 0.0266 mL 0.1328 mL 0.2657 mL 0.5313 mL 0.6642 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    去乙酰基土槿甲酸; Deacetylpseudolaric acid A CFN97313 82508-37-0 C20H26O5 = 346.4 5mg QQ客服:3257982914
    土槿皮甲酸; Pseudolaric acid A CFN92814 82508-32-5 C22H28O6 = 388.5 20mg QQ客服:1413575084
    土荆皮甲酸-O-β-D-葡萄糖苷 ; Pseudolaric acid A-O-beta-D-glucopyranoside CFN90725 98891-44-2 C28H38O11 = 550.6 10mg QQ客服:2056216494
    土槿甲酸甲酯A; Methyl pseudolarate A CFN97310 82508-33-6 C23H30O6 = 402.5 5mg QQ客服:2159513211
    去甲氧基去乙酰氧基土槿甲酸B; Demethoxydeacetoxypseudolaric acid B CFN97312 82508-36-9 C20H24O7 = 376.4 5mg QQ客服:2159513211
    土荆皮丙酸; Pseudolaric Acid C CFN90724 82601-41-0 C21H26O7 = 390.4 10mg QQ客服:3257982914
    土槿皮乙酸; 土荆皮乙酸; Pseudolaric Acid B CFN99527 82508-31-4 C23H28O8 = 432.46 20mg QQ客服:1457312923
    土荆皮乙酸葡萄糖苷; Pseudolaric acid B-O-beta-D-glucopyranoside CFN90726 98891-41-9 C29H38O13 = 594.6 20mg QQ客服:3257982914
    土槿甲酸甲酯B; Methyl pseudolarate B CFN97311 82508-34-7 C24H30O8 = 446.5 5mg QQ客服:1457312923
    叶含荚宁C; Vibsanin C CFN97692 74690-89-4 C25H36O5 = 416.56 5mg QQ客服:1457312923

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